PMCOL 200: CHEMOTHERAPY - QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS.
100% Correct 92
Incorrect 0
1 of 92
Term
What are the 3 key roles of tumor suppressor genes?
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1. Growth factors and their
receptors
2.Signal transducers 1. Anti-folates
3.Transcription factors/ nuclear 2.Pyrimidine analogues
transducers 3.Purine analogues
4. Programmed cell death
regulators
1. Environmental
factors (ie. Radiation 1. Repress cell division
exposure, pollution, tobacco) 2.Initiate apoptosis after
2.Genetic factors irreversible DNA damage.
3.Viral infections 3.Code for repair DNA
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, 2 of 92
Term
What feature do most alkylating agents have?
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They are bifunctional; form
covalent bonds at two
They are non-reactive; block DNA nucleophilic sites on different
bases without forming bonds DNA bases to induce
interstrand and/or intrastrand
cross-links
They are reversible; detach from They are monofunctional; bind to a
DNA easily without causing damage single site on DNA to prevent
replication
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3 of 92
Term
What reproductive side effect can chemotherapy cause?
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Ovulation Paralysis
, Skin Integrity Sterility
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4 of 92
Term
What are the phases of the cell cycle?
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1. Often advanced by the time of detection
2.Cannot leave cells behind after treatment ends
3.They are your own cells
4. Many adverse side-effects
5. Drug resistance
G1, S, G2, G0, M
Alopecia (hair loss)
anthracyclines
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, 5 of 92
Term
What are oncogenes?
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Mutated genes that repair Genes that suppress cell growth
damaged DNA and division
Genes that regulate Mutated protooncogenes that
immune response to cause uncontrolled cell
tumors growth
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6 of 92
Term
What side effect affects hair due to chemotherapy?
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Skin atrophy Depression of growth
Diarrhea Alopecia (hair loss)
Don't know?
ANSWERS WITH COMPLETE SOLUTIONS.
100% Correct 92
Incorrect 0
1 of 92
Term
What are the 3 key roles of tumor suppressor genes?
Give this one a try later!
1. Growth factors and their
receptors
2.Signal transducers 1. Anti-folates
3.Transcription factors/ nuclear 2.Pyrimidine analogues
transducers 3.Purine analogues
4. Programmed cell death
regulators
1. Environmental
factors (ie. Radiation 1. Repress cell division
exposure, pollution, tobacco) 2.Initiate apoptosis after
2.Genetic factors irreversible DNA damage.
3.Viral infections 3.Code for repair DNA
Don't know?
, 2 of 92
Term
What feature do most alkylating agents have?
Give this one a try later!
They are bifunctional; form
covalent bonds at two
They are non-reactive; block DNA nucleophilic sites on different
bases without forming bonds DNA bases to induce
interstrand and/or intrastrand
cross-links
They are reversible; detach from They are monofunctional; bind to a
DNA easily without causing damage single site on DNA to prevent
replication
Don't know?
3 of 92
Term
What reproductive side effect can chemotherapy cause?
Give this one a try later!
Ovulation Paralysis
, Skin Integrity Sterility
Don't know?
4 of 92
Term
What are the phases of the cell cycle?
Give this one a try later!
1. Often advanced by the time of detection
2.Cannot leave cells behind after treatment ends
3.They are your own cells
4. Many adverse side-effects
5. Drug resistance
G1, S, G2, G0, M
Alopecia (hair loss)
anthracyclines
Don't know?
, 5 of 92
Term
What are oncogenes?
Give this one a try later!
Mutated genes that repair Genes that suppress cell growth
damaged DNA and division
Genes that regulate Mutated protooncogenes that
immune response to cause uncontrolled cell
tumors growth
Don't know?
6 of 92
Term
What side effect affects hair due to chemotherapy?
Give this one a try later!
Skin atrophy Depression of growth
Diarrhea Alopecia (hair loss)
Don't know?
