“ONS/ONCC Chemotherapy Immunotherapy Certificate
2026 | 170 Questions & Answers | Exam Prep”
1. In a scenario where a patient has advanced cancer with no possibility of cure,
which treatment goal should be prioritized and why?
Prevention
Control
Palliation
Cure
2. Describe the significance of the '-zumab' suffix in monoclonal antibodies and
its implications for treatment.
The '-zumab' suffix indicates that the monoclonal antibody is
humanized, meaning it has components derived from both mouse
and human sources.
The '-zumab' suffix signifies that the antibody is a combination of
multiple antibodies.
The '-zumab' suffix indicates that the antibody is derived entirely from
mouse sources.
The '-zumab' suffix signifies that the antibody is fully human and has no
mouse components.
3. What role does Substance P play in the process of vomiting?
It is one of the most important neurotransmitters involved in
vomiting.
It enhances the immune response during chemotherapy.
It acts as an anti-nausea agent.
, It is a primary component of chemotherapy drugs.
4. Describe how the action of a kinase can affect cellular activity.
A kinase degrades cellular components to regulate metabolism.
A kinase modifies the activity of target molecules by adding
phosphate groups, which can activate or deactivate them.
A kinase synthesizes proteins that are essential for cell division.
A kinase removes phosphate groups, leading to increased cellular
activity.
5. Describe the significance of administering a single dose of an antineoplastic
agent in cancer therapy.
Administering a single dose allows for targeted treatment at a
specific time, which can enhance the effectiveness of the therapy.
Single doses are only used in combination with other therapies.
Single doses are primarily used for palliative care rather than curative
treatment.
A single dose is less effective than multiple doses due to the body's
rapid metabolism.
6. Which of the following points should the pharmacist council a person on
regarding oxaliplatin?
If he has trouble swallowing the tablets, crush them and mix in
applesauce.
Avoid eating grapefruit or drinking grapefruit juice while taking
capecitabine
Take tablets with food
, Avoid drinking cold liquids while taking oxaliplatin
7. What is the definition of febrile neutropenia?
Temperature ≥ 39.0°C and ANC < 1500 cells/mmr
Temperature ≥ 38.3°C and ANC < 500 cells/mm³
Temperature ≥ 38.3°C and ANC < 1000 cells/mmr
Temperature ≥ 37.5°C and ANC < 750 cells/mmr
8. If a patient experiences severe CINV, which class of medications targeting
serotonin might be prescribed to alleviate their symptoms?
Antihistamines
5-HT3 receptor antagonists
Corticosteroids
Dopamine agonists
9. After chemotherapy administration the nadir typically occurs when?
Within 7-10 weeks after treatment
Within 7-10 hours of therapy
Within 7-10 days after treatment
10. What is the time frame in which an immediate hypersensitivity reaction can
occur after infusion?
5 minutes to 6 hours
30 minutes to 1 hour
24 hours to 48 hours
, 1 hour to 2 hours
11. Which of the following is true regarding immune-related response criteria?
Pseudoprogression is common with checkpoint inhibitors where there
is initial tumor regression followed by an increase in tumor burden.
RECIST criteria is used routinely with all therapies and types of
cancers, solid tumors or blood malignancies.
Response to immune-mediated therapies occurs almost immediately
and tumor response can be seen on scans within 4 weeks of therapy.
Because of the pseudoprogression phenomenon, it is
recommended that immune-mediated therapies have their own
subset of RECIST criteria guidelines.
12. If a patient is not responding to traditional chemotherapy, which type of
immunotherapy might be considered as an alternative treatment option?
Nonspecific immunotherapies
Immune checkpoint inhibitors
Adoptive cell therapy (CAR T-cell therapy)
Monoclonal antibodies
13. If a drug targets the Mitotic phase of cell division, what effect would it likely
have on rapidly dividing cancer cells?
It would only affect their metabolic processes.
It would inhibit their ability to divide and proliferate.
It would have no effect on their division.
It would enhance their growth and division.
2026 | 170 Questions & Answers | Exam Prep”
1. In a scenario where a patient has advanced cancer with no possibility of cure,
which treatment goal should be prioritized and why?
Prevention
Control
Palliation
Cure
2. Describe the significance of the '-zumab' suffix in monoclonal antibodies and
its implications for treatment.
The '-zumab' suffix indicates that the monoclonal antibody is
humanized, meaning it has components derived from both mouse
and human sources.
The '-zumab' suffix signifies that the antibody is a combination of
multiple antibodies.
The '-zumab' suffix indicates that the antibody is derived entirely from
mouse sources.
The '-zumab' suffix signifies that the antibody is fully human and has no
mouse components.
3. What role does Substance P play in the process of vomiting?
It is one of the most important neurotransmitters involved in
vomiting.
It enhances the immune response during chemotherapy.
It acts as an anti-nausea agent.
, It is a primary component of chemotherapy drugs.
4. Describe how the action of a kinase can affect cellular activity.
A kinase degrades cellular components to regulate metabolism.
A kinase modifies the activity of target molecules by adding
phosphate groups, which can activate or deactivate them.
A kinase synthesizes proteins that are essential for cell division.
A kinase removes phosphate groups, leading to increased cellular
activity.
5. Describe the significance of administering a single dose of an antineoplastic
agent in cancer therapy.
Administering a single dose allows for targeted treatment at a
specific time, which can enhance the effectiveness of the therapy.
Single doses are only used in combination with other therapies.
Single doses are primarily used for palliative care rather than curative
treatment.
A single dose is less effective than multiple doses due to the body's
rapid metabolism.
6. Which of the following points should the pharmacist council a person on
regarding oxaliplatin?
If he has trouble swallowing the tablets, crush them and mix in
applesauce.
Avoid eating grapefruit or drinking grapefruit juice while taking
capecitabine
Take tablets with food
, Avoid drinking cold liquids while taking oxaliplatin
7. What is the definition of febrile neutropenia?
Temperature ≥ 39.0°C and ANC < 1500 cells/mmr
Temperature ≥ 38.3°C and ANC < 500 cells/mm³
Temperature ≥ 38.3°C and ANC < 1000 cells/mmr
Temperature ≥ 37.5°C and ANC < 750 cells/mmr
8. If a patient experiences severe CINV, which class of medications targeting
serotonin might be prescribed to alleviate their symptoms?
Antihistamines
5-HT3 receptor antagonists
Corticosteroids
Dopamine agonists
9. After chemotherapy administration the nadir typically occurs when?
Within 7-10 weeks after treatment
Within 7-10 hours of therapy
Within 7-10 days after treatment
10. What is the time frame in which an immediate hypersensitivity reaction can
occur after infusion?
5 minutes to 6 hours
30 minutes to 1 hour
24 hours to 48 hours
, 1 hour to 2 hours
11. Which of the following is true regarding immune-related response criteria?
Pseudoprogression is common with checkpoint inhibitors where there
is initial tumor regression followed by an increase in tumor burden.
RECIST criteria is used routinely with all therapies and types of
cancers, solid tumors or blood malignancies.
Response to immune-mediated therapies occurs almost immediately
and tumor response can be seen on scans within 4 weeks of therapy.
Because of the pseudoprogression phenomenon, it is
recommended that immune-mediated therapies have their own
subset of RECIST criteria guidelines.
12. If a patient is not responding to traditional chemotherapy, which type of
immunotherapy might be considered as an alternative treatment option?
Nonspecific immunotherapies
Immune checkpoint inhibitors
Adoptive cell therapy (CAR T-cell therapy)
Monoclonal antibodies
13. If a drug targets the Mitotic phase of cell division, what effect would it likely
have on rapidly dividing cancer cells?
It would only affect their metabolic processes.
It would inhibit their ability to divide and proliferate.
It would have no effect on their division.
It would enhance their growth and division.
