1|Page
(IgNS) Ig Certified Pharmacist (IgCP) Credential
Practice Exam Actual Test||Verified Exam!!!||
Questions and Correct Answers With Rationales
LATEST THIS YEAR||Newest Exam!!!
When an individual is vaccinated with a live or modified
virus, a functioning immune system will identify it as non-
self, and initially, the levels of ____ will increase, followed
by the manufacture of ____ - Answer-IgM
IgG
IgM has receptors on the surface of B cells, and the higher
levels of IgM help 'trigger' the creation of IgG molecules
specific to the invading pathogen.
It takes ___ days for peak levels of IgG to be created after
IgM triggers the manufacture - Answer-10-12 days
The _____ process utilizes ethanol, changes in pH,
addition of salts, and temperature changes to cause
plasma to separate into fractions, hence the term
fractionation - Answer-Cohn
,2|Page
T/F: all Ig products must be manufactured with at least
one complementary viral inactivation and or removal step -
Answer-False, at least two steps
Which product is available in a lyophilized powder? -
Answer-Gammagard SD is a lyophilized powder and must
be reconstituted to a 5% or 10% concentration before
administration.
For Ig products, refrigerated conditions are in the range of
________ and room temperature is listed as _______ -
Answer-Refrigerated: 2°C - 8°C (36°F - 46°F)
Room Temp: ≤25°C (≤77°F)
T/F: Most, if not all, manufacturers state the product
should be discarded if frozen - Answer-True
List the labeled indications of IVIG (8) - Answer-1) Antiviral
prophylaxis- hep A, measles, varicella
2) CIDP
3) Dermatomyositis/polymyositis
4) Immune thrombocytopenia
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5) Hypogammaglobulinemia, prophylaxis against bacterial
infection
6) Myasthenia gravis
7)Kawasaki syndrome
8) Multifocal motor neuropathy
T/F: The pooling of Ig products in the home setting outside
of a sterile environment remains controversial and may not
be compliant with USP <797> guidelines - Answer-True
If a filter is used, it is recommended to use a ____ micron
filter as smaller pore sizes can result in the filter becoming
clogged due to the viscosity of some Ig products - Answer-
>0.2
What are the highest risk factors for an IgA anaphylactic
reaction? - Answer-The risk is highest in patients with
undetectable levels of IgA, anti-IgA antibodies of the IgE
type, and the absence of IgA-positive B cells.
A 10% solution is preferred in which of the following:
a. neonates
, 4|Page
b. patients with renal impairment
c. patients with congestive heart failure
d. patients with significant lung impairment
e. all of the above - Answer-E
______ are used in Ig products to prevent aggregation of
the Igs as aggregates have been shown to cause some
ADRs - Answer-Stabilizers
Answer the following about cyclosporine
1. Drug class
2. Brand name
3. MOA
4. ADE
5. Onset of action - Answer-1. Immunosuppressant
2. Gengraf; Neoral; SandIMMUNE
3. Inhibition of production and release of interleukin II and
inhibits interleukin II-induced activation of resting T-
lymphocytes.
4. Renal tox and hypertension
5. 2-6 hours
(IgNS) Ig Certified Pharmacist (IgCP) Credential
Practice Exam Actual Test||Verified Exam!!!||
Questions and Correct Answers With Rationales
LATEST THIS YEAR||Newest Exam!!!
When an individual is vaccinated with a live or modified
virus, a functioning immune system will identify it as non-
self, and initially, the levels of ____ will increase, followed
by the manufacture of ____ - Answer-IgM
IgG
IgM has receptors on the surface of B cells, and the higher
levels of IgM help 'trigger' the creation of IgG molecules
specific to the invading pathogen.
It takes ___ days for peak levels of IgG to be created after
IgM triggers the manufacture - Answer-10-12 days
The _____ process utilizes ethanol, changes in pH,
addition of salts, and temperature changes to cause
plasma to separate into fractions, hence the term
fractionation - Answer-Cohn
,2|Page
T/F: all Ig products must be manufactured with at least
one complementary viral inactivation and or removal step -
Answer-False, at least two steps
Which product is available in a lyophilized powder? -
Answer-Gammagard SD is a lyophilized powder and must
be reconstituted to a 5% or 10% concentration before
administration.
For Ig products, refrigerated conditions are in the range of
________ and room temperature is listed as _______ -
Answer-Refrigerated: 2°C - 8°C (36°F - 46°F)
Room Temp: ≤25°C (≤77°F)
T/F: Most, if not all, manufacturers state the product
should be discarded if frozen - Answer-True
List the labeled indications of IVIG (8) - Answer-1) Antiviral
prophylaxis- hep A, measles, varicella
2) CIDP
3) Dermatomyositis/polymyositis
4) Immune thrombocytopenia
,3|Page
5) Hypogammaglobulinemia, prophylaxis against bacterial
infection
6) Myasthenia gravis
7)Kawasaki syndrome
8) Multifocal motor neuropathy
T/F: The pooling of Ig products in the home setting outside
of a sterile environment remains controversial and may not
be compliant with USP <797> guidelines - Answer-True
If a filter is used, it is recommended to use a ____ micron
filter as smaller pore sizes can result in the filter becoming
clogged due to the viscosity of some Ig products - Answer-
>0.2
What are the highest risk factors for an IgA anaphylactic
reaction? - Answer-The risk is highest in patients with
undetectable levels of IgA, anti-IgA antibodies of the IgE
type, and the absence of IgA-positive B cells.
A 10% solution is preferred in which of the following:
a. neonates
, 4|Page
b. patients with renal impairment
c. patients with congestive heart failure
d. patients with significant lung impairment
e. all of the above - Answer-E
______ are used in Ig products to prevent aggregation of
the Igs as aggregates have been shown to cause some
ADRs - Answer-Stabilizers
Answer the following about cyclosporine
1. Drug class
2. Brand name
3. MOA
4. ADE
5. Onset of action - Answer-1. Immunosuppressant
2. Gengraf; Neoral; SandIMMUNE
3. Inhibition of production and release of interleukin II and
inhibits interleukin II-induced activation of resting T-
lymphocytes.
4. Renal tox and hypertension
5. 2-6 hours
