NSG 533 Advanced Pharmacology Test
1 Week 4 Questions and Answers
1. Which of the following SSRIs requires up to a 5-week washout period
because of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline
ANS C
2. Which of the following symptoms is most likely to improve within
approximately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep
ANS D
3. Of the following combinations of medications, which one would you
want to avoid?
,A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole
ANS B
4. A 26-year-old man with a history of depression has been taking
sertraline 200 mg/day for 12 weeks with no response. The patient has
no other complications. The physician asks for your recommendation.
The most reasonable recommen- dation would be to
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline
ANS D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
C. MAOI-meperidine
D. MAOI-ziprasidone
ANS C
, 6. A 23-year-old married white woman comes to the outpatient
psychiatric clinic
complaining of decreased sleep, decreased appetite, decreased
concentration, depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks'
duration.
She has
no history of psychiatric illness and takes no medications except for
Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication
to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime
ANS B
7. A 36-year-old man is admitted to the hospital for a severe
methicillin-resistant Staphylococcus aureus diabetic foot infection
and is started on linezolid 600 mg IV every 12 hours. His medication
profile includes paroxetine 40 mg every morning, trazodone 100 mg
at bedtime as needed for sleep, and metformin 1000 mg po twice
daily. After 3
days on these medications, the patient becomes agitated, confused,
and di- aphoretic and develops myoclonic jerks. Which of the
1 Week 4 Questions and Answers
1. Which of the following SSRIs requires up to a 5-week washout period
because of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline
ANS C
2. Which of the following symptoms is most likely to improve within
approximately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep
ANS D
3. Of the following combinations of medications, which one would you
want to avoid?
,A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole
ANS B
4. A 26-year-old man with a history of depression has been taking
sertraline 200 mg/day for 12 weeks with no response. The patient has
no other complications. The physician asks for your recommendation.
The most reasonable recommen- dation would be to
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline
ANS D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
C. MAOI-meperidine
D. MAOI-ziprasidone
ANS C
, 6. A 23-year-old married white woman comes to the outpatient
psychiatric clinic
complaining of decreased sleep, decreased appetite, decreased
concentration, depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks'
duration.
She has
no history of psychiatric illness and takes no medications except for
Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication
to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime
ANS B
7. A 36-year-old man is admitted to the hospital for a severe
methicillin-resistant Staphylococcus aureus diabetic foot infection
and is started on linezolid 600 mg IV every 12 hours. His medication
profile includes paroxetine 40 mg every morning, trazodone 100 mg
at bedtime as needed for sleep, and metformin 1000 mg po twice
daily. After 3
days on these medications, the patient becomes agitated, confused,
and di- aphoretic and develops myoclonic jerks. Which of the
