Pharmaceutics Exam 1 Questions || || || ||
With Answers || ||
The most suitable dosage form in the clinical Phases 1
|| || || || || || || || || ||
and 2 of drug product development is - CORRECT
|| || || || || || || || ||
ANSWER(S)✔✔Capsule
The largest and smallest sizes of hard-shell capsule
|| || || || || || || ||
respectively available for compounding for human use || || || || || || ||
are sizes - CORRECT ANSWER(S)✔✔000-largest
|| || || ||
5-smallest
An appropriate formulation of hard-shell capsules must
|| || || || || || ||
contain which of the following basic ingredients? (3) -
|| || || || || || || || ||
CORRECT ANSWER(S)✔✔Propylene glycol || ||
gelatin
titanium dioxide ||
The presence of which of the following chemical
|| || || || || || || ||
components distinguishes soft gelatin capsule shells || || || || || ||
,from hard shell capsules? - CORRECT
|| || || || || ||
ANSWER(S)✔✔Plasticizers
Some important factors to be considered when selecting
|| || || || || || || ||
a capsule size are: (2) - CORRECT
|| || || || || || ||
ANSWER(S)✔✔Density of powder || ||
Dose size ||
In capsule and other solid unit dosage forms evaluation,
|| || || || || || || || ||
the test which indicates the potential for drug absorption
|| || || || || || || ||
in vivo (i.e. bioavailability) is - CORRECT
|| || || || || || || ||
ANSWER(S)✔✔dissolution rate ||
A pharmacist received a prescription directing to
|| || || || || || ||
dispense capsules. The active ingredient/drug was a
|| || || || || || ||
water miscible, non-volatile liquid. Which of the
|| || || || || || ||
following types of capsule shells should s/he use to
|| || || || || || || || ||
compound the prescription? - CORRECT || || || || ||
ANSWER(S)✔✔Soft gelatin capsule shell || || ||
Extemporaneously prepared capsules are sealed by - || || || || || || ||
CORRECT ANSWER(S)✔✔Lightly coating the inner || || || || ||
surface of the cap with a warm gelatin solution
|| || || || || || || ||
,For the content uniformity test for capsules, what is/are
|| || || || || || || || ||
applicable? - CORRECT ANSWER(S)✔✔Concentration of || || || || ||
active ingredient should be within 85-115% of the label
|| || || || || || || || ||
claim
Why should highly soluble chloride salts not be
|| || || || || || || ||
dispensed in hard gelatin capsules? - CORRECT || || || || || || ||
ANSWER(S)✔✔Rapid release may cause gastric irritation || || || || ||
and harm patient
|| || ||
Which piece of the hard-shell capsule is filled with
|| || || || || || || || ||
powder? - CORRECT ANSWER(S)✔✔The body || || || ||
The procedure used to load powder on an ointment slab
|| || || || || || || || || ||
into capsule shell during hand-filling operation is known
|| || || || || || || ||
as: - CORRECT ANSWER(S)✔✔Punching
|| || ||
According to the USP Chapter <795> guideline in || || || || || || || ||
assigning expiration dates to extemporaneously || || || || ||
compounded capsules containing stable powders.....(3) - || || || || || ||
CORRECT ANSWER(S)✔✔Six months if prepared with || || || || || ||
USP/NF grade ingredients || ||
25% of remaining expiration dating if prepared from
|| || || || || || || ||
commercial products ||
, Any date if evidence is available to support such dating
|| || || || || || || || ||
Which of the following types of drugs may be better
|| || || || || || || || || ||
presented in capsule rather than tablet dosage form? (3)
|| || || || || || || ||
- CORRECT ANSWER(S)✔✔Drugs of objectionable odor
|| || || || || || ||
or taste ||
Drugs that are sensitive to oxygen and/or moisture
|| || || || || || ||
Drugs of poor inherent compressibility
|| || || ||
When the content of drug substance in a capsule dosage
|| || || || || || || || || ||
unit is less than 25 mg or less than 25 % of capsule
|| || || || || || || || || || || || ||
weight, the USP recommendation for uniformity
|| || || || || ||
assessment is - CORRECT ANSWER(S)✔✔Content || || || || ||
uniformity test ||
Which of the following physical properties of a drug
|| || || || || || || || ||
substance determines the capsule shell's fill weight|| || || || || || ||
capacity? - CORRECT ANSWER(S)✔✔Tapped bulk || || || || ||
density of the powder || || ||
In the extemporaneous preparation of a dosage form,
|| || || || || || || ||
levigation is used to - CORRECT ANSWER(S)✔✔Reduce || || || || || || ||
particle size ||
With Answers || ||
The most suitable dosage form in the clinical Phases 1
|| || || || || || || || || ||
and 2 of drug product development is - CORRECT
|| || || || || || || || ||
ANSWER(S)✔✔Capsule
The largest and smallest sizes of hard-shell capsule
|| || || || || || || ||
respectively available for compounding for human use || || || || || || ||
are sizes - CORRECT ANSWER(S)✔✔000-largest
|| || || ||
5-smallest
An appropriate formulation of hard-shell capsules must
|| || || || || || ||
contain which of the following basic ingredients? (3) -
|| || || || || || || || ||
CORRECT ANSWER(S)✔✔Propylene glycol || ||
gelatin
titanium dioxide ||
The presence of which of the following chemical
|| || || || || || || ||
components distinguishes soft gelatin capsule shells || || || || || ||
,from hard shell capsules? - CORRECT
|| || || || || ||
ANSWER(S)✔✔Plasticizers
Some important factors to be considered when selecting
|| || || || || || || ||
a capsule size are: (2) - CORRECT
|| || || || || || ||
ANSWER(S)✔✔Density of powder || ||
Dose size ||
In capsule and other solid unit dosage forms evaluation,
|| || || || || || || || ||
the test which indicates the potential for drug absorption
|| || || || || || || ||
in vivo (i.e. bioavailability) is - CORRECT
|| || || || || || || ||
ANSWER(S)✔✔dissolution rate ||
A pharmacist received a prescription directing to
|| || || || || || ||
dispense capsules. The active ingredient/drug was a
|| || || || || || ||
water miscible, non-volatile liquid. Which of the
|| || || || || || ||
following types of capsule shells should s/he use to
|| || || || || || || || ||
compound the prescription? - CORRECT || || || || ||
ANSWER(S)✔✔Soft gelatin capsule shell || || ||
Extemporaneously prepared capsules are sealed by - || || || || || || ||
CORRECT ANSWER(S)✔✔Lightly coating the inner || || || || ||
surface of the cap with a warm gelatin solution
|| || || || || || || ||
,For the content uniformity test for capsules, what is/are
|| || || || || || || || ||
applicable? - CORRECT ANSWER(S)✔✔Concentration of || || || || ||
active ingredient should be within 85-115% of the label
|| || || || || || || || ||
claim
Why should highly soluble chloride salts not be
|| || || || || || || ||
dispensed in hard gelatin capsules? - CORRECT || || || || || || ||
ANSWER(S)✔✔Rapid release may cause gastric irritation || || || || ||
and harm patient
|| || ||
Which piece of the hard-shell capsule is filled with
|| || || || || || || || ||
powder? - CORRECT ANSWER(S)✔✔The body || || || ||
The procedure used to load powder on an ointment slab
|| || || || || || || || || ||
into capsule shell during hand-filling operation is known
|| || || || || || || ||
as: - CORRECT ANSWER(S)✔✔Punching
|| || ||
According to the USP Chapter <795> guideline in || || || || || || || ||
assigning expiration dates to extemporaneously || || || || ||
compounded capsules containing stable powders.....(3) - || || || || || ||
CORRECT ANSWER(S)✔✔Six months if prepared with || || || || || ||
USP/NF grade ingredients || ||
25% of remaining expiration dating if prepared from
|| || || || || || || ||
commercial products ||
, Any date if evidence is available to support such dating
|| || || || || || || || ||
Which of the following types of drugs may be better
|| || || || || || || || || ||
presented in capsule rather than tablet dosage form? (3)
|| || || || || || || ||
- CORRECT ANSWER(S)✔✔Drugs of objectionable odor
|| || || || || || ||
or taste ||
Drugs that are sensitive to oxygen and/or moisture
|| || || || || || ||
Drugs of poor inherent compressibility
|| || || ||
When the content of drug substance in a capsule dosage
|| || || || || || || || || ||
unit is less than 25 mg or less than 25 % of capsule
|| || || || || || || || || || || || ||
weight, the USP recommendation for uniformity
|| || || || || ||
assessment is - CORRECT ANSWER(S)✔✔Content || || || || ||
uniformity test ||
Which of the following physical properties of a drug
|| || || || || || || || ||
substance determines the capsule shell's fill weight|| || || || || || ||
capacity? - CORRECT ANSWER(S)✔✔Tapped bulk || || || || ||
density of the powder || || ||
In the extemporaneous preparation of a dosage form,
|| || || || || || || ||
levigation is used to - CORRECT ANSWER(S)✔✔Reduce || || || || || || ||
particle size ||
