WGU D116 Unit 8 OA Review Question
& Answers 2026
A nursing student asks for clarification on the differences
between the mechanisms of spontaneous mutation and
conjugation in acquired resistance of microbes.
Which statement is correct? - CORRECT ANSWERS
✔✔Spontaneous mutation leads to resistance to only one
antimicrobial agent
A patient receiving a cephalosporin develops a secondary
intestinal infection caused by Clostridium difficile.
What is an appropriate treatment for this patient? -
CORRECT ANSWERS ✔✔Discontinuing the
cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by
Pseudomonas aeruginosa. The culture and sensitivity
report shows sensitivity to all aminoglycosides. The
provider knows that the rate of resistance to gentamicin
is common in this hospital.
Which medication should the provider be expected to
order? - CORRECT ANSWERS ✔✔Amikacin
When resistance to gentamicin and tobramycin is
common, amikacin is the drug of choice for the initial
treatment of aminoglycoside-sensitive infections
,WGU D116 Unit 8 OA Review Question
& Answers 2026
A child with otitis media has had three ear infections in
the past year. The child has just completed a ten-day
course of amoxicillin with no improvement. The parent
asks the provider why this drug is not working because it
has worked in the past.
What should the provider tell the patient? - CORRECT
ANSWERS ✔✔"The bacteria have synthesized
penicillinase"
Beta-lactamases are enzymes that cleave the beta-
lactam ring and render the PCN inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to
know why it does not cause gastrointestinal upset as
other over-the-counter pain medications do.
Which property of acetaminophen is the most likely
explanation for this? - CORRECT ANSWERS ✔✔It has
minimal effects at peripheral sites
Tylenol central effects
NSAIDs peripheral effects
, WGU D116 Unit 8 OA Review Question
& Answers 2026
A patient who has arthritis has been taking ibuprofen and
a glucocorticoid medication. The patient reports having
tarry stools but denies gastric pain.
Which action by the provider is correct? - CORRECT
ANSWERS ✔✔Prescribing an antiulcer medication
Glucocorticoid therapy, especially when combined with
NSAIDs, can increase the risk of gastric ulcer and possibly
bleeding
A patient will begin taking hydroxychloroquine for
rheumatoid arthritis. The patient is currently taking high-
dose NSAIDs and methotrexate.
What should the patient be taught about
hydroxychloroquine? - CORRECT ANSWERS ✔✔An
eye exam is necessary at the beginning of therapy with
this drug
Can cause retinal damage - eye exam at the onset of
treatment as well as every 6 months during treatment
& Answers 2026
A nursing student asks for clarification on the differences
between the mechanisms of spontaneous mutation and
conjugation in acquired resistance of microbes.
Which statement is correct? - CORRECT ANSWERS
✔✔Spontaneous mutation leads to resistance to only one
antimicrobial agent
A patient receiving a cephalosporin develops a secondary
intestinal infection caused by Clostridium difficile.
What is an appropriate treatment for this patient? -
CORRECT ANSWERS ✔✔Discontinuing the
cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by
Pseudomonas aeruginosa. The culture and sensitivity
report shows sensitivity to all aminoglycosides. The
provider knows that the rate of resistance to gentamicin
is common in this hospital.
Which medication should the provider be expected to
order? - CORRECT ANSWERS ✔✔Amikacin
When resistance to gentamicin and tobramycin is
common, amikacin is the drug of choice for the initial
treatment of aminoglycoside-sensitive infections
,WGU D116 Unit 8 OA Review Question
& Answers 2026
A child with otitis media has had three ear infections in
the past year. The child has just completed a ten-day
course of amoxicillin with no improvement. The parent
asks the provider why this drug is not working because it
has worked in the past.
What should the provider tell the patient? - CORRECT
ANSWERS ✔✔"The bacteria have synthesized
penicillinase"
Beta-lactamases are enzymes that cleave the beta-
lactam ring and render the PCN inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to
know why it does not cause gastrointestinal upset as
other over-the-counter pain medications do.
Which property of acetaminophen is the most likely
explanation for this? - CORRECT ANSWERS ✔✔It has
minimal effects at peripheral sites
Tylenol central effects
NSAIDs peripheral effects
, WGU D116 Unit 8 OA Review Question
& Answers 2026
A patient who has arthritis has been taking ibuprofen and
a glucocorticoid medication. The patient reports having
tarry stools but denies gastric pain.
Which action by the provider is correct? - CORRECT
ANSWERS ✔✔Prescribing an antiulcer medication
Glucocorticoid therapy, especially when combined with
NSAIDs, can increase the risk of gastric ulcer and possibly
bleeding
A patient will begin taking hydroxychloroquine for
rheumatoid arthritis. The patient is currently taking high-
dose NSAIDs and methotrexate.
What should the patient be taught about
hydroxychloroquine? - CORRECT ANSWERS ✔✔An
eye exam is necessary at the beginning of therapy with
this drug
Can cause retinal damage - eye exam at the onset of
treatment as well as every 6 months during treatment
