NUR 258 FINAL TEST PAPER 2026
COMPLETE QUESTIONS AND ANSWERS
VERIFIED
▶ The major reason for not crushing a sustained release capsule is that, if
crushed, the coated beads of the drugs could possibly result in:
A. Disintegration
B. Toxicity
C. Malabsorption
D. Deterioration. Answer: B. Toxicity
▶ Which of the following substances is the most likely to be absorbed in
the intestines rather than in the stomach?
A. Sodium bicarbonate
B. Ascorbic acid
C. Salicylic acid
D. Glucose. Answer: A. Sodium bicarbonate
▶ 30. Which of the following variables is a factor in drug absorption?
A. The smaller the surface area for absorption, the more rapidly the drug is
absorbed.
B. A rich blood supply to the area of absorption leads to better absorption.
C. The less soluble the drug, the more easily it is absorbed.
D. Ionized drugs are easily absorbed across the cell membrane.. Answer:
B. A rich blood supply to the area of absorption leads to better absorption
▶ An advantage of prescribing a sublingual medication is that the
medication is: A. Absorbed rapidly
B. Excreted rapidly
C. Metabolized minimally
D. Distributed equally. Answer: A. Absorbed rapidly
▶ Drugs that use CYP 3A4 isoenzymes for metabolism may:
A. Induce the metabolism of another drug
B. Inhibit the metabolism of another drug
C. Both A and B
,D. Neither A nor B. Answer: C. Both A and B
▶ Therapeutic drug levels are drawn when a drug reaches steady state.
Drugs reach steady state:
A. After the second dose
B. After four to five half-lives
C. When the patient feels the full effect of the drug
D. One hour after IV administration. Answer: B. After four to five half-lives
▶ Up-regulation or hypersensitization may lead to:
A. Increased response to a drug
B. Decreased response to a drug
C. An exaggerated response if the drug is withdrawn
D. Refractoriness or complete lack of response. Answer: C. An
exaggerated response if the drug is withdrawn
▶ Which of the following patients would be at higher risk of experiencing
adverse drug reactions (ADRs):
A. A 32-year-old male
B. A 22-year-old female
C. A 3-month-old female
D. A 48-year-old male. Answer: C. A 3-month-old female
▶ Infants and young children are at higher risk of ADRs due to:
A. Immature renal function in school-age children
B. Lack of safety and efficacy studies in the pediatric population
C. Children's skin being thicker than adults, requiring higher dosages of
topical medication
D. Infant boys having a higher proportion of muscle mass, leading to a
higher volume of distribution. Answer: B. Lack of safety and efficacy studies
in the pediatric population
▶ The elderly are at high risk of ADRs due to:
A. Having greater muscle mass than younger adults, leading to higher
volume of distribution
B. The extensive studies that have been conducted on drug safety in this
age group
C. The blood-brain barrier being less permeable, requiring higher doses to
achieve therapeutic effect
, D. Age-related decrease in renal function. Answer: D. Age-related
decrease in renal function
▶ The type of adverse drug reaction that is the result of an unwanted but
otherwise normal pharmacological action of a drug given in the usual
therapeutic doses is
A. Type A
B. Type B
C. Type C
D. Type D. Answer: A. Type A
▶ Digoxin may cause a Type A adverse drug reaction due to:
A. Idiosyncratic effects
B. Its narrow therapeutic index
C. Being a teratogen
D. Being a carcinogen. Answer: B. Its narrow therapeutic index
▶ Changes in the individual pharmacokinetic parameters of adsorption,
distribution, or elimination may result in high concentrations of the drug in
the body, leading to which type of adverse drug reaction?
A. Type A
B. Type C
C. Type D
D. Type E. Answer: A. Type A
▶ According to the World Health Organization Classification, Type B
adverse reactions are:
A. When a drug is a teratogen
B. When a drug is carcinogenic
C. A delayed ADR, such as renal failure
D. An allergic or idiosyncratic response. Answer: D. An allergic or
idiosyncratic response
▶ Sarah developed a rash after using a topical medication. This is a Type
__ allergic drug reaction.
A. I
B. II
C. III
D. IV. Answer: D. IV
COMPLETE QUESTIONS AND ANSWERS
VERIFIED
▶ The major reason for not crushing a sustained release capsule is that, if
crushed, the coated beads of the drugs could possibly result in:
A. Disintegration
B. Toxicity
C. Malabsorption
D. Deterioration. Answer: B. Toxicity
▶ Which of the following substances is the most likely to be absorbed in
the intestines rather than in the stomach?
A. Sodium bicarbonate
B. Ascorbic acid
C. Salicylic acid
D. Glucose. Answer: A. Sodium bicarbonate
▶ 30. Which of the following variables is a factor in drug absorption?
A. The smaller the surface area for absorption, the more rapidly the drug is
absorbed.
B. A rich blood supply to the area of absorption leads to better absorption.
C. The less soluble the drug, the more easily it is absorbed.
D. Ionized drugs are easily absorbed across the cell membrane.. Answer:
B. A rich blood supply to the area of absorption leads to better absorption
▶ An advantage of prescribing a sublingual medication is that the
medication is: A. Absorbed rapidly
B. Excreted rapidly
C. Metabolized minimally
D. Distributed equally. Answer: A. Absorbed rapidly
▶ Drugs that use CYP 3A4 isoenzymes for metabolism may:
A. Induce the metabolism of another drug
B. Inhibit the metabolism of another drug
C. Both A and B
,D. Neither A nor B. Answer: C. Both A and B
▶ Therapeutic drug levels are drawn when a drug reaches steady state.
Drugs reach steady state:
A. After the second dose
B. After four to five half-lives
C. When the patient feels the full effect of the drug
D. One hour after IV administration. Answer: B. After four to five half-lives
▶ Up-regulation or hypersensitization may lead to:
A. Increased response to a drug
B. Decreased response to a drug
C. An exaggerated response if the drug is withdrawn
D. Refractoriness or complete lack of response. Answer: C. An
exaggerated response if the drug is withdrawn
▶ Which of the following patients would be at higher risk of experiencing
adverse drug reactions (ADRs):
A. A 32-year-old male
B. A 22-year-old female
C. A 3-month-old female
D. A 48-year-old male. Answer: C. A 3-month-old female
▶ Infants and young children are at higher risk of ADRs due to:
A. Immature renal function in school-age children
B. Lack of safety and efficacy studies in the pediatric population
C. Children's skin being thicker than adults, requiring higher dosages of
topical medication
D. Infant boys having a higher proportion of muscle mass, leading to a
higher volume of distribution. Answer: B. Lack of safety and efficacy studies
in the pediatric population
▶ The elderly are at high risk of ADRs due to:
A. Having greater muscle mass than younger adults, leading to higher
volume of distribution
B. The extensive studies that have been conducted on drug safety in this
age group
C. The blood-brain barrier being less permeable, requiring higher doses to
achieve therapeutic effect
, D. Age-related decrease in renal function. Answer: D. Age-related
decrease in renal function
▶ The type of adverse drug reaction that is the result of an unwanted but
otherwise normal pharmacological action of a drug given in the usual
therapeutic doses is
A. Type A
B. Type B
C. Type C
D. Type D. Answer: A. Type A
▶ Digoxin may cause a Type A adverse drug reaction due to:
A. Idiosyncratic effects
B. Its narrow therapeutic index
C. Being a teratogen
D. Being a carcinogen. Answer: B. Its narrow therapeutic index
▶ Changes in the individual pharmacokinetic parameters of adsorption,
distribution, or elimination may result in high concentrations of the drug in
the body, leading to which type of adverse drug reaction?
A. Type A
B. Type C
C. Type D
D. Type E. Answer: A. Type A
▶ According to the World Health Organization Classification, Type B
adverse reactions are:
A. When a drug is a teratogen
B. When a drug is carcinogenic
C. A delayed ADR, such as renal failure
D. An allergic or idiosyncratic response. Answer: D. An allergic or
idiosyncratic response
▶ Sarah developed a rash after using a topical medication. This is a Type
__ allergic drug reaction.
A. I
B. II
C. III
D. IV. Answer: D. IV
