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Chamberlain NR 507 Advanced Pathophysiology
Midterm 2026/2027 | Actual Exam Questions, Verified
Answers & Detailed Rationales | Grade A
1. A nurse is teaching about Type I hypersensitivity. Which are examples of Type I
hypersensitivity? (Select all that apply.)
A. Allergic rhinitis
B. Anaphylactic reaction
C. Contact dermatitis
D. Rheumatoid arthritis
E. Graves' disease
Correct Answer:A, B
Rationale: Type I hypersensitivity includes allergic rhinitis and anaphylactic reactions.
Contact dermatitis is Type IV, rheumatoid arthritis is Type III, and Graves' disease is Type
II.
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2. A nurse is teaching about Type I hypersensitivity. What immunoglobulin mediates
Type I reactions?
A. IgA
B. IgD
C. IgE
D. IgG
Correct Answer:C
Rationale: Type I hypersensitivity reactions are mediated by IgE antibodies, which bind
to mast cells and basophils, triggering histamine release.
3. A nurse is teaching about Type I hypersensitivity. What cells are primarily involved
in Type I reactions?
A. T lymphocytes
B. B lymphocytes
C. Mast cells
D. Macrophages
Correct Answer:C
Rationale: Mast cells are the primary effector cells in Type I hypersensitivity, releasing
histamine and other inflammatory mediators upon IgE cross-linking.
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4. A nurse is assessing a patient with a Type I hypersensitivity reaction. What are
expected symptoms? (Select all that apply.)
A. Local: itching, immediate rash
B. Systemic: wheezing
C. Delayed rash at 24-72 hours
D. Tissue-specific destruction
E. Immune complex deposition
Correct Answer:A, B
Rationale: Type I reactions cause local symptoms (itching, rash, urticaria) and systemic
symptoms (wheezing, anaphylaxis). Delayed rash is Type IV, tissue destruction is Type II,
and immune complex deposition is Type III.
5. A nurse is caring for a patient experiencing anaphylaxis. What is the main
treatment?
A. Antihistamines
B. Corticosteroids
C. Epinephrine
D. Bronchodilators
Correct Answer:C
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Rationale: Epinephrine is the first-line treatment for anaphylaxis, reversing
bronchospasm, vasodilation, and increased capillary permeability.
6. A nurse is teaching about Type II hypersensitivity. What is another name for Type II
hypersensitivity?
A. Delayed hypersensitivity
B. Immune complex reaction
C. Cytotoxic reaction, tissue-specific
D. Anaphylactic reaction
Correct Answer:C
Rationale: Type II hypersensitivity is also known as a cytotoxic or tissue-specific
reaction, where antibodies bind to antigens on cell surfaces, leading to cell destruction.
7. A nurse is teaching about Type II hypersensitivity. What cells are involved in Type II
reactions?
A. Mast cells
B. T lymphocytes
C. Macrophages
D. Basophils
Correct Answer:C
Chamberlain NR 507 Advanced Pathophysiology
Midterm 2026/2027 | Actual Exam Questions, Verified
Answers & Detailed Rationales | Grade A
1. A nurse is teaching about Type I hypersensitivity. Which are examples of Type I
hypersensitivity? (Select all that apply.)
A. Allergic rhinitis
B. Anaphylactic reaction
C. Contact dermatitis
D. Rheumatoid arthritis
E. Graves' disease
Correct Answer:A, B
Rationale: Type I hypersensitivity includes allergic rhinitis and anaphylactic reactions.
Contact dermatitis is Type IV, rheumatoid arthritis is Type III, and Graves' disease is Type
II.
,2|Page
2. A nurse is teaching about Type I hypersensitivity. What immunoglobulin mediates
Type I reactions?
A. IgA
B. IgD
C. IgE
D. IgG
Correct Answer:C
Rationale: Type I hypersensitivity reactions are mediated by IgE antibodies, which bind
to mast cells and basophils, triggering histamine release.
3. A nurse is teaching about Type I hypersensitivity. What cells are primarily involved
in Type I reactions?
A. T lymphocytes
B. B lymphocytes
C. Mast cells
D. Macrophages
Correct Answer:C
Rationale: Mast cells are the primary effector cells in Type I hypersensitivity, releasing
histamine and other inflammatory mediators upon IgE cross-linking.
,3|Page
4. A nurse is assessing a patient with a Type I hypersensitivity reaction. What are
expected symptoms? (Select all that apply.)
A. Local: itching, immediate rash
B. Systemic: wheezing
C. Delayed rash at 24-72 hours
D. Tissue-specific destruction
E. Immune complex deposition
Correct Answer:A, B
Rationale: Type I reactions cause local symptoms (itching, rash, urticaria) and systemic
symptoms (wheezing, anaphylaxis). Delayed rash is Type IV, tissue destruction is Type II,
and immune complex deposition is Type III.
5. A nurse is caring for a patient experiencing anaphylaxis. What is the main
treatment?
A. Antihistamines
B. Corticosteroids
C. Epinephrine
D. Bronchodilators
Correct Answer:C
, 4|Page
Rationale: Epinephrine is the first-line treatment for anaphylaxis, reversing
bronchospasm, vasodilation, and increased capillary permeability.
6. A nurse is teaching about Type II hypersensitivity. What is another name for Type II
hypersensitivity?
A. Delayed hypersensitivity
B. Immune complex reaction
C. Cytotoxic reaction, tissue-specific
D. Anaphylactic reaction
Correct Answer:C
Rationale: Type II hypersensitivity is also known as a cytotoxic or tissue-specific
reaction, where antibodies bind to antigens on cell surfaces, leading to cell destruction.
7. A nurse is teaching about Type II hypersensitivity. What cells are involved in Type II
reactions?
A. Mast cells
B. T lymphocytes
C. Macrophages
D. Basophils
Correct Answer:C
