by Kenneth Murphy, Casey Weaver | 9780815345053
|2017-2018 | Chapter 1-16 | All Chapters with Answers
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Test Bank - Janeway's Immunobiology, 9th Edition (Murphy, 2017)
JANEWAY'S !MMUNOB!OLOGY, 9TH ED!T!ON
CHAPTER 1: BAS!C CONCEPTS !N !MMUNOLOGY
The or!g!ns of vertebrate !mmune cells
1.1 Mult!ple cho!ce: !n pat!ents w!th lymphomas, the cancer cells !nvade the bone marrow and
destroy the env!ronment requ!red for normal hematopo!es!s. Th!s leads to bone marrow fa!lure,
wh!ch d!srupts the product!on of hematopo!et!c cell l!neages. All of the follow!ng cell types would
be affected by th!s EXCEPT:
A. Red blood cells
B. Macrophages
C. Lymphocytes
D. Endothel!al cells
E. Granulocytes
Pr!nc!ples of !nnate !mmun!ty
1-1 Commensal organ!sms cause l!ttle host damage wh!le pathogens damage host t!ssues by a var!ety
of mechan!sms
1.2 True/False: Our !mmune system eff!c!ently k!lls all categor!es of m!crobes that attempt to colon!ze
our bod!es.
1.3 Short answer: Pathogen!c organ!sms cause damage to the host by a variety of mechanisms,
depending on the category of the pathogen and its mode of replication in WWW.TBSM.WS
the host. Give an example of two different types of pathogens that are unlikely to be dealt with
by the same mechanism of immune protection.
1-2 Anatomic and chemical barriers are the first defense against pathogens
1.4 Multiple choice: The skin and bodily secretions provide the first line of defense against infection.
One response in this category that is common during upper respiratory virus infections is:
A. Production of antibodies
B. Infiltration by white blood cells
C. Mucus production
D. Increased saliva production E. Fever
1-3 The immune system is activated by inflammatory inducers that indicate the presence of pathogens
or tissue damage
1.5 Short answer: A common mechanism by which sensor cells in the host detect microorganisms
relies on the production of unique microbial components not found in the host. Propose a
strategy by which a clever microbe could evade this type of response.
1.6 Multiple choice: Adaptive immune responses are slow to develop, taking days to weeks after
exposure to reach their peak. However, these responses are more specific than innate responses,
and also generate immunological memory. These latter features,
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