, Test Bank
mm
to mm accompany
Psychopharmacology, Third Edition
mm mm
Meyer m m • mmQuenzer
Chapter 1: Principles of Pharmacology
mm mm mm mm
Multiple m m Choice
1. refer(s) mmto mmspecific mmmolecular mmchanges mmthat mmoccur mmwhen mma mmdrug
mm binds mmto mma mmparticular mmtarget mmsite mmor mmreceptor, mmwhile aremmthe mmresulting
mmwidespread mmalterations mmin mmfunction.
a. Drug mmaction; m m therapeutic m m effects
b. Side mmeffects; m m drug mmeffects
c. Therapeutic mmeffects; m m side mmeffects
d. Drug mmaction; m m drug mmeffects
Answer: mmd
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
2. After mmdrug mmadministration m m has mmoccurred, mmthe mmamount m m of mmdrug mmin mmthe
mmblood mmthat mmis mmfree mmto mmbind mmat mmspecific mmtarget mmsites mmis mmreferred mmto mmas
a. the mmtherapeutic mmdose.
b. first-pass mmeffects.
c. bioavailability.
d. ED50.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mm Action
3. The mmspecific mmmolecular mmchanges mmthat mmoccur mmwhen mma mmdrug mmbinds mmto mma
mmparticular mmtarget mmsite mmor mmreceptor mmare mmreferred mmto mmas
a. drug mmeffects.
b. drug mmaction.
c. side mmeffects.
d. placebo mmeffects.
Answer: mmb
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
4. Which mmof mmthe m m following mm is m m not m m a mmpossible mm explanation m m for mmplacebo m m effects?
a. Pavlovian mmconditioning
b. Genetic mmvariation
c. Drug mmcompetition
d. Expectation m m of m m outcome
Answer: mmc
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
Page mm 1 m m of
247
,5. The administration m m of mmoxytocin mm has m m been m m proposed mmas m m a m m treatment
m m for mm autism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors m m Determining mmDrug mmAction
6. Which mmfactor m m does m m not m m affect m m the mm pharmacokinetics m m of mm a mmdrug?
a. Route m m of mmadministration
b. Lipid mm solubility
c. Depot mm binding
d. Drug mmaction
Answer: mmd
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
7. First-pass mmmetabolism m m occurs mmwhen mm drugs mm are mmtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mm Action
8. The mmarea mm postrema m m is m m one m m area m m in m m the mm brain m m where m m the is mm not m m complete.
a. cerebrospinal mmfluid
b. blood–brain mmbarrier
c. choroid mm plexus
d. phospholipid m m membrane
Answer: mmb
Textbook mmReference: mmPharmacokinetic mm Factors mmDetermining mmDrug mmAction
9. First-pass mmmetabolism m m occurs mm with mm orally mmadministered mm drugs mm because
a. their mm absorption m m is m m slowed m m by mmfood.
b. drugs m m absorbed m m into mmthe mmbloodstream m m from mmthe mmstomach m m go mmto mmthe
mmliver m m on mmthe mmway mmto mmgeneral mmcirculation.
c. drugs m m must m m first m m survive mmthe mm acidic m m environment m m of m m the mm stomach.
d. salivarymmenzymes m m in m m the mmmouth m m begin m m the mmprocess m m of m m metabolism.
Answer: mmb
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
10. Toxic mmsubstances m m in m m the mmblood m m trigger m m a mmvomiting mmresponse m m by mmactivating
mm the
a. blood–brain mmbarrier.
b. choroid mm plexus.
c. area mmpostrema.
d. median mmeminence.
Page mm 2 m m of
247
, Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
11. Drugs mmadministered mm _ have mmthe mm most m m rapid m m onset m m of m m action.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: mmd
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
12. Ionization mmof mma mmdrug mmdepends mmon mmthe of mmthe mmsolution mmand mmthe of
mmthe mmdrug.
a. pH; m m pKa
b. pKa; m m pH
c. concentration; mmlipid m m solubility
d. pH; mmconcentration
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mmAction
13. The mmabsorption m m of m m a mmdrug m m depends m m on m m all m m of mm the m m following m m except
a. lipid m m solubility.
b. ionization.
c. body mmtemperature.
d. the mm concentration m m of m m the mmdrug.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mmAction
14. Drugs mm that m m are should m m be mmavoided m m by mmwomen m m of m m childbearing m m age.
a. teratogenic
b. able mmto m m cross mm the m m placental m m barrier
c. psychoactive
d. highly mmlipid-soluble
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
15. Agents mm that m m induce mm developmental m m abnormalities mm in m m a mm fetus m m are mmknown m m as
a. psychoactive mmdrugs.
b. illicit mm drugs.
c. teratogens.
d. placental mmdrugs.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
16. Depot mm binding mm is m m said m m to mmoccur mm when m m drugs
a. bind mm to mm their mm target m m sites.
Page mm 3 m m of
247
mm
to mm accompany
Psychopharmacology, Third Edition
mm mm
Meyer m m • mmQuenzer
Chapter 1: Principles of Pharmacology
mm mm mm mm
Multiple m m Choice
1. refer(s) mmto mmspecific mmmolecular mmchanges mmthat mmoccur mmwhen mma mmdrug
mm binds mmto mma mmparticular mmtarget mmsite mmor mmreceptor, mmwhile aremmthe mmresulting
mmwidespread mmalterations mmin mmfunction.
a. Drug mmaction; m m therapeutic m m effects
b. Side mmeffects; m m drug mmeffects
c. Therapeutic mmeffects; m m side mmeffects
d. Drug mmaction; m m drug mmeffects
Answer: mmd
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
2. After mmdrug mmadministration m m has mmoccurred, mmthe mmamount m m of mmdrug mmin mmthe
mmblood mmthat mmis mmfree mmto mmbind mmat mmspecific mmtarget mmsites mmis mmreferred mmto mmas
a. the mmtherapeutic mmdose.
b. first-pass mmeffects.
c. bioavailability.
d. ED50.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mm Action
3. The mmspecific mmmolecular mmchanges mmthat mmoccur mmwhen mma mmdrug mmbinds mmto mma
mmparticular mmtarget mmsite mmor mmreceptor mmare mmreferred mmto mmas
a. drug mmeffects.
b. drug mmaction.
c. side mmeffects.
d. placebo mmeffects.
Answer: mmb
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
4. Which mmof mmthe m m following mm is m m not m m a mmpossible mm explanation m m for mmplacebo m m effects?
a. Pavlovian mmconditioning
b. Genetic mmvariation
c. Drug mmcompetition
d. Expectation m m of m m outcome
Answer: mmc
Textbook mmReference: mmPharmacology: m m The mmScience m m of mmDrug mmAction
Page mm 1 m m of
247
,5. The administration m m of mmoxytocin mm has m m been m m proposed mmas m m a m m treatment
m m for mm autism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors m m Determining mmDrug mmAction
6. Which mmfactor m m does m m not m m affect m m the mm pharmacokinetics m m of mm a mmdrug?
a. Route m m of mmadministration
b. Lipid mm solubility
c. Depot mm binding
d. Drug mmaction
Answer: mmd
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
7. First-pass mmmetabolism m m occurs mmwhen mm drugs mm are mmtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mm Action
8. The mmarea mm postrema m m is m m one m m area m m in m m the mm brain m m where m m the is mm not m m complete.
a. cerebrospinal mmfluid
b. blood–brain mmbarrier
c. choroid mm plexus
d. phospholipid m m membrane
Answer: mmb
Textbook mmReference: mmPharmacokinetic mm Factors mmDetermining mmDrug mmAction
9. First-pass mmmetabolism m m occurs mm with mm orally mmadministered mm drugs mm because
a. their mm absorption m m is m m slowed m m by mmfood.
b. drugs m m absorbed m m into mmthe mmbloodstream m m from mmthe mmstomach m m go mmto mmthe
mmliver m m on mmthe mmway mmto mmgeneral mmcirculation.
c. drugs m m must m m first m m survive mmthe mm acidic m m environment m m of m m the mm stomach.
d. salivarymmenzymes m m in m m the mmmouth m m begin m m the mmprocess m m of m m metabolism.
Answer: mmb
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
10. Toxic mmsubstances m m in m m the mmblood m m trigger m m a mmvomiting mmresponse m m by mmactivating
mm the
a. blood–brain mmbarrier.
b. choroid mm plexus.
c. area mmpostrema.
d. median mmeminence.
Page mm 2 m m of
247
, Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
11. Drugs mmadministered mm _ have mmthe mm most m m rapid m m onset m m of m m action.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: mmd
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
12. Ionization mmof mma mmdrug mmdepends mmon mmthe of mmthe mmsolution mmand mmthe of
mmthe mmdrug.
a. pH; m m pKa
b. pKa; m m pH
c. concentration; mmlipid m m solubility
d. pH; mmconcentration
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mmAction
13. The mmabsorption m m of m m a mmdrug m m depends m m on m m all m m of mm the m m following m m except
a. lipid m m solubility.
b. ionization.
c. body mmtemperature.
d. the mm concentration m m of m m the mmdrug.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mmDetermining mmDrug mmAction
14. Drugs mm that m m are should m m be mmavoided m m by mmwomen m m of m m childbearing m m age.
a. teratogenic
b. able mmto m m cross mm the m m placental m m barrier
c. psychoactive
d. highly mmlipid-soluble
Answer: mma
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
15. Agents mm that m m induce mm developmental m m abnormalities mm in m m a mm fetus m m are mmknown m m as
a. psychoactive mmdrugs.
b. illicit mm drugs.
c. teratogens.
d. placental mmdrugs.
Answer: mmc
Textbook mmReference: mmPharmacokinetic m m Factors mm Determining mmDrug mmAction
16. Depot mm binding mm is m m said m m to mmoccur mm when m m drugs
a. bind mm to mm their mm target m m sites.
Page mm 3 m m of
247
