NR546 EXAM QUESTIONS WITH
CORRECT DETAILED ANSWERS;
100% GUARANTEED PASS
5HT, NE Dysfunction causes what mood related symptoms -
correct answer- Increased negative affect:
depressed mood
guilt
fear/anxiety
hostility
irritability
loneliness
appetite changes
90% of serotonin receptors are in the __________ and
_________ are within the brain - correct answer- GI
tract, only 10%
*which causes GI side effects
Acute agitation in mania may be treated with: - correct
answer- rapid-acting oral, inhaled, or IM antimanic agents
,Adjunct treatment for depression - correct answer-
Antipsychotic medications are sometimes prescribed at low
doses as adjunctive medications for severe depression
Alpha-1 adrenergic effects - correct answer- Orthostatic
hypotension
Anticholinergic effects - correct answer- Dry mouth
Blurred vision
Urinary retention
Constipation
Antidepressants are used cautiously in clients with bipolar
disorder and never as ________________. - correct
answer- monotherapy
-Antidepressants should be combined with a mood stabilizer to
prevent the onset of a hypomanic or manic episode
Antidepressants Important Prescribing Considerations: Black Box
Warning - correct answer- Suicide Risk with
Antidepressant Drugs
,-Clients with depression may consider or attempt suicide
-risk for suicide may increase at the start of treatment
-Antidepressant-induced suicide is more prevalent in children,
adolescents, and adults younger than 25 years.
Antidepressants Important Prescribing Considerations: Drug-
Drug Interactions - correct answer- Most antidepressant
medications have serious drug-drug interactions. Carefully
review the client's history and current prescriptions before
selecting a medication.
Antidepressants Important Prescribing Considerations:
Serotonin Syndrome - correct answer- potentially life-
threatening condition reported with the use of serotonergic
antidepressants
-especially when they are used concomitantly with other
serotonergic drugs (such as triptans, tricyclic antidepressants,
fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
John's Wort), and with drugs that impair serotonin metabolism
(particularly MAOIs)
S/S
-mental status changes (e.g., agitation, hallucinations, delirium,
and coma)
, -autonomic instability (e.g., tachycardia, labile blood pressure,
dizziness, diaphoresis, flushing, hyperthermia)
-neuromuscular symptoms (e.g., tremor, rigidity, myoclonus,
hyperreflexia, incoordination)
-seizures, and/or gastrointestinal symptoms (e.g., nausea,
vomiting, diarrhea)
If such symptoms occur, clients should discontinue serotonergic
agents and initiate treatment of symptoms.
Clients should be educated about the signs and symptoms of
serotonin syndrome and monitored
-particularly during treatment initiation and dose increases.
Antidepressants Lifespan Considerations: Breastfeeding -
correct answer- Infant irritability should be monitored
when SNRIs are prescribed.
Antidepressants Lifespan Considerations: Children - correct
answer- Antidepressants increase the risk of death by
suicide in children and adults younger than 25.
CORRECT DETAILED ANSWERS;
100% GUARANTEED PASS
5HT, NE Dysfunction causes what mood related symptoms -
correct answer- Increased negative affect:
depressed mood
guilt
fear/anxiety
hostility
irritability
loneliness
appetite changes
90% of serotonin receptors are in the __________ and
_________ are within the brain - correct answer- GI
tract, only 10%
*which causes GI side effects
Acute agitation in mania may be treated with: - correct
answer- rapid-acting oral, inhaled, or IM antimanic agents
,Adjunct treatment for depression - correct answer-
Antipsychotic medications are sometimes prescribed at low
doses as adjunctive medications for severe depression
Alpha-1 adrenergic effects - correct answer- Orthostatic
hypotension
Anticholinergic effects - correct answer- Dry mouth
Blurred vision
Urinary retention
Constipation
Antidepressants are used cautiously in clients with bipolar
disorder and never as ________________. - correct
answer- monotherapy
-Antidepressants should be combined with a mood stabilizer to
prevent the onset of a hypomanic or manic episode
Antidepressants Important Prescribing Considerations: Black Box
Warning - correct answer- Suicide Risk with
Antidepressant Drugs
,-Clients with depression may consider or attempt suicide
-risk for suicide may increase at the start of treatment
-Antidepressant-induced suicide is more prevalent in children,
adolescents, and adults younger than 25 years.
Antidepressants Important Prescribing Considerations: Drug-
Drug Interactions - correct answer- Most antidepressant
medications have serious drug-drug interactions. Carefully
review the client's history and current prescriptions before
selecting a medication.
Antidepressants Important Prescribing Considerations:
Serotonin Syndrome - correct answer- potentially life-
threatening condition reported with the use of serotonergic
antidepressants
-especially when they are used concomitantly with other
serotonergic drugs (such as triptans, tricyclic antidepressants,
fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
John's Wort), and with drugs that impair serotonin metabolism
(particularly MAOIs)
S/S
-mental status changes (e.g., agitation, hallucinations, delirium,
and coma)
, -autonomic instability (e.g., tachycardia, labile blood pressure,
dizziness, diaphoresis, flushing, hyperthermia)
-neuromuscular symptoms (e.g., tremor, rigidity, myoclonus,
hyperreflexia, incoordination)
-seizures, and/or gastrointestinal symptoms (e.g., nausea,
vomiting, diarrhea)
If such symptoms occur, clients should discontinue serotonergic
agents and initiate treatment of symptoms.
Clients should be educated about the signs and symptoms of
serotonin syndrome and monitored
-particularly during treatment initiation and dose increases.
Antidepressants Lifespan Considerations: Breastfeeding -
correct answer- Infant irritability should be monitored
when SNRIs are prescribed.
Antidepressants Lifespan Considerations: Children - correct
answer- Antidepressants increase the risk of death by
suicide in children and adults younger than 25.
