RELIAS RN PHARMACOLOGY A –
COMPLETE TEST BANK
2025/2026 Updated Edition –
Questions with Detailed
Rationales
Verified Questions, Correct
Answers, and NCLEX-Style
Practice
,Detail Information
Exam Name Relias RN Pharmacology A
Edition 2025/2026 Latest Update
Format Multiple Choice, NCLEX-Style
Includes Correct Answers + Detailed Rationales
Difficulty A+ Graded Material
Topics Drug Classifications, Dosage Calculations, Side Effects, Drug Interactions,
Covered Patient Education, Safe Administration
SECTION 1: CARDIOVASCULAR MEDICATIONS (Questions 1-25)
Question 1: A patient is ordered to receive digoxin. Vital signs are: BP 130/75, HR 52, RR
16, O2 Sat 100%. What should the nurse do next?
A) Administer the digoxin as ordered
B) Hold digoxin and call the provider
C) Give half the dose
D) Recheck vital signs in 30 minutes
Answer: B – Hold digoxin and call the provider
,Rationale: Digoxin should be held if the apical pulse is <60 in an adult. Bradycardia
increases the risk of digoxin toxicity. This is a classic nursing intervention that requires
immediate action to prevent adverse effects .
Question 2: A patient taking digoxin (Lanoxin) has an AM potassium level of 3.0 mEq/L.
This level may:
A) Decrease the effectiveness of digoxin
B) Increase the risk of digoxin toxicity
C) Cause hyperkalemia
D) Have no effect on digoxin therapy
Answer: B – Increase the risk of digoxin toxicity
Rationale: Hypokalemia (low potassium) potentiates the effects of digoxin and increases
the risk of toxicity. Patients on digoxin should maintain normal potassium levels. ECG
changes and cardiac arrhythmias may occur with toxicity .
Question 3: Sildenafil (Viagra) is prescribed to treat a patient with erectile dysfunction.
The nurse should question this prescription if which of the following is noted in the
patient's history?
A) Hypertension
B) Diabetes mellitus
C) Use of nitroglycerin
D) Hyperlipidemia
Answer: C – Use of nitroglycerin
, Rationale: Sildenafil is contraindicated with nitrates (such as nitroglycerin) due to the
risk of severe, life-threatening hypotension. This is a critical drug interaction frequently
tested on Relias exams .
Question 4: Which statement made by a patient regarding hydrochlorothiazide (HCTZ) is
correct?
A) "I should take this medication at bedtime."
B) "I should take extra care when standing up or changing positions."
C) "I can stop taking this when my blood pressure is normal."
D) "I need to avoid all foods containing potassium."
Answer: B – "I should take extra care when standing up or changing positions."
Rationale: HCTZ can cause orthostatic hypotension. Patients should rise slowly from
sitting or lying positions. It's usually taken in the morning (not bedtime) to avoid nocturia,
and must be taken consistently even when BP is normal. Potassium levels should be
monitored, not completely avoided .
Question 5: Which of the following anticoagulants is MOST commonly administered for
DVT prophylaxis in a patient who has undergone a hip replacement?
A) Heparin
B) Enoxaparin (Lovenox)
C) Aspirin
D) Warfarin
Answer: B – Enoxaparin (Lovenox)
COMPLETE TEST BANK
2025/2026 Updated Edition –
Questions with Detailed
Rationales
Verified Questions, Correct
Answers, and NCLEX-Style
Practice
,Detail Information
Exam Name Relias RN Pharmacology A
Edition 2025/2026 Latest Update
Format Multiple Choice, NCLEX-Style
Includes Correct Answers + Detailed Rationales
Difficulty A+ Graded Material
Topics Drug Classifications, Dosage Calculations, Side Effects, Drug Interactions,
Covered Patient Education, Safe Administration
SECTION 1: CARDIOVASCULAR MEDICATIONS (Questions 1-25)
Question 1: A patient is ordered to receive digoxin. Vital signs are: BP 130/75, HR 52, RR
16, O2 Sat 100%. What should the nurse do next?
A) Administer the digoxin as ordered
B) Hold digoxin and call the provider
C) Give half the dose
D) Recheck vital signs in 30 minutes
Answer: B – Hold digoxin and call the provider
,Rationale: Digoxin should be held if the apical pulse is <60 in an adult. Bradycardia
increases the risk of digoxin toxicity. This is a classic nursing intervention that requires
immediate action to prevent adverse effects .
Question 2: A patient taking digoxin (Lanoxin) has an AM potassium level of 3.0 mEq/L.
This level may:
A) Decrease the effectiveness of digoxin
B) Increase the risk of digoxin toxicity
C) Cause hyperkalemia
D) Have no effect on digoxin therapy
Answer: B – Increase the risk of digoxin toxicity
Rationale: Hypokalemia (low potassium) potentiates the effects of digoxin and increases
the risk of toxicity. Patients on digoxin should maintain normal potassium levels. ECG
changes and cardiac arrhythmias may occur with toxicity .
Question 3: Sildenafil (Viagra) is prescribed to treat a patient with erectile dysfunction.
The nurse should question this prescription if which of the following is noted in the
patient's history?
A) Hypertension
B) Diabetes mellitus
C) Use of nitroglycerin
D) Hyperlipidemia
Answer: C – Use of nitroglycerin
, Rationale: Sildenafil is contraindicated with nitrates (such as nitroglycerin) due to the
risk of severe, life-threatening hypotension. This is a critical drug interaction frequently
tested on Relias exams .
Question 4: Which statement made by a patient regarding hydrochlorothiazide (HCTZ) is
correct?
A) "I should take this medication at bedtime."
B) "I should take extra care when standing up or changing positions."
C) "I can stop taking this when my blood pressure is normal."
D) "I need to avoid all foods containing potassium."
Answer: B – "I should take extra care when standing up or changing positions."
Rationale: HCTZ can cause orthostatic hypotension. Patients should rise slowly from
sitting or lying positions. It's usually taken in the morning (not bedtime) to avoid nocturia,
and must be taken consistently even when BP is normal. Potassium levels should be
monitored, not completely avoided .
Question 5: Which of the following anticoagulants is MOST commonly administered for
DVT prophylaxis in a patient who has undergone a hip replacement?
A) Heparin
B) Enoxaparin (Lovenox)
C) Aspirin
D) Warfarin
Answer: B – Enoxaparin (Lovenox)
