ASTHMA AND COPD - PHARM EXAM 3| TOP SCORES MADE SIMPLE | TRUSTED TEST SOLUTIONS!

ASTHMA AND COPD - PHARM EXAM 3| TOP SCORES
MADE SIMPLE | TRUSTED TEST SOLUTIONS!
Asthma medications general classes Answer: SABA, LABA, ICS, Montelukast
(Singulair), Theophylline (Theochron), biologics

SABA MOA Answer: causes relaxation of bronchial smooth muscle by acting on beta 2
receptors

SABA SE Answer: tachycardia, shakiness, nervousness, dizziness

beta receptors are sympathetic NS receptors, so you get sympathetic NS responses as
side effects

SABA concerns Answer: appropriate inhaler technique is a must; spacers can make it
easier

spacers --> plastic chamber that encloses the medicine, instead of having to time
breaths with inhalers

SABA drug names Answer: Albuterol MDI (ProAir, Proventil, Ventolin)

Levalbuterol MDI (Xopenex)

both available as solutions and nebulizers

SABA inhaler - directions for usage Answer: shake inhaler. breathe all you air out, bring
inhaler to lips, nice slow breath, hold breath for 10 seconds, breathe normally. 2 puffs at
time, each puff separated by 5 minutes.

LABA MOA Answer: causes relaxation of bronchial smooth muscle by acting on beta 2
receptors

LABA side effects Answer: headache, pain, throat irritation, dizziness

LABA concerns Answer: NOT to be used as a monotherapy in asthma (risk of
morbidity) - typically in combo inhalers with ICS

LABA drug names Answer: Formoterol (Foradil, Perforomist), Salmeterol (Serevent)

Foradil and Perforomist --> nebulized products
Serevent --> diskus

ICS MOA Answer: anti-inflammatory activity
ICS side effects Answer: throat irritation, cough, hoarseness, thrush, nausea, arthralgia

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, ICS concerns Answer: rinse mouth after use to prevent thrush

ICS drug names/formulations Answer: Beclomethasone (Qvar Handihaler)

Budesonide (Pulmicort; Comes as nebules and MDI)

Ciclesonide (Alvesco MDI)
Flunisolide (Aerospan MDI)

Fluticasone (Flovent, Arnuity Ellipta; Flovent is a diskus or MDI; Arnuity - diskus)

Mometasone (Asmanex MDI)

Diskus info Answer: dry powder inhaler. no propellant like in MDI, so we need a sharp
quick breath to get it to our lungs because there is nothing else driving it in there. Likely
would not want to use in sick pts that can't breathe in sharp.

hold like a hamburger, do 2 quick sharp breaths at the puncture

ICS and LABA combo names Answer: -Advair (fluticasone + salmeterol)

-Breo Ellipta (Fluticasone +vilanterol)

-Dulera (mometasone +formoterol)

-Symbicort (Budesonide + formoterol)

Advair (Fluticasone + salmeterol) formulation Answer: diskus or MDI
Breo Ellipta (Fluticasone +vilanterol) formulation Answer: diskus only

Dulera (mometasone +formoterol) formulation Answer: MDI only

Symbicort (budesonide + formoterol) formulation Answer: MDI only

Montelukast (singulair) MOA Answer: selective leukotriene receptor antagonist that
inhibits the cysteinyl leukotriene receptor

Montelukast (singulair) side effects Answer: headache, dizziness, fatigue

Montelukast (singulair) concerns Answer: neuropyschiatric events- abnormal dreams,
agitation, aggression, anxiety, depression, sleep disturbance

Montelukast (singulair) is available as Answer: granules, chewables, tablets (no
inhalers!)

very kid friendly!

Montelukast (singulair) dosing Answer: dosed based on age
1-5 y/o: 4 mg daily

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