PNEUMONIA/URI - PHARM FINAL EXAM| TOP SCORES
MADE SIMPLE | TRUSTED TEST SOLUTIONS!
outpatient pneumonia common pathogens Answer: S. pneumo
M. pneumo
H. flu
C. pneumo
Resp viruses
inpatient (non-ICU) pneumonia - common pathoges Answer: S. pneumo
M. pneumo
H. flu
C. pneumo
Legionella
Aspiration
Resp. viruses
inpatient (ICU) pneumonia - common pathogens Answer: S. pneumo
S. aureus
Legionella
Gram - bacilli
H. flu
initial treatment for outpatient CAP with no comorbidities and no risk factors for MRSA or
Pseudomonas Answer: Amoxicillin or doxy or macrolide (if local pneumococcal
resistance is <25%)
initial treatment for outpatient CAP with comorbidities Answer: combo therapy with
augmentin or cephalosporin AND macrolide or doxy
monotherapy w/ resp FQ (moxifloxacin, levofloxacin)
what are comorbidities that we should be careful of in CAP treatment Answer: chronic
heart, lung liver, or renal disease, diabetes, alcoholism, malignancy, asplenia
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
, what are risk factors for MRSA and/or pseudomonas we need to be careful of in treating
CAP Answer: prior respiratory isolation of MRSA or Pseudomonas or recent
hospitalization AND receipt of parenteral abx in the last 90 days
amoxicillin abx type Answer: beta lactam, PCN like
amoxicillin MOA Answer: inhibits bacterial cell wall synthesis by binding to one or more
PBPs
amoxicillin SE Answer: rash, n, d
amoxicillin concerns Answer: dose adjust in renal impairment
allergy
doxycycline abx type Answer: tetracycline
doxycycline MOA Answer: inhibits protein synthesis by binding w/ the 30S (and
possibly 50S) ribosomal subunits
doxycycline SE Answer: rash, photosensitivity, n, v, d, dysphagia, heartburn
doxycycline concerns Answer: don't use in those under 8 y/o --> causes tooth
hyperpigmentation, tooth enamel hypoplasia, permanent tooth discoloration
azithromycin abx type Answer: macrolide
azithromycin MOA Answer: inhibits RNA-dependent protein synthesis at the chain
elongation step by binding the 50S subunit
azithromycin SE Answer: abd pain, n, v, d, rash
azithromycin concerns Answer: growing resistance to S. pneumo
QT prolongation risk
caution in hepatic dysfunction
clarithromycin abx type Answer: macrolide
clarithromycin MOA Answer: inhibits RNA-dependent protein synthesis at chain
elongation step by binding to the 50S subunit
clarithromycin SE Answer: abd pain, v, d, dysgeusia, rash
clarithromycin conerns Answer: contraindicated in QT prolongation
CYP 3A4 inhibitor (DDI)
requires dose adjustment in renal impairment
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
MADE SIMPLE | TRUSTED TEST SOLUTIONS!
outpatient pneumonia common pathogens Answer: S. pneumo
M. pneumo
H. flu
C. pneumo
Resp viruses
inpatient (non-ICU) pneumonia - common pathoges Answer: S. pneumo
M. pneumo
H. flu
C. pneumo
Legionella
Aspiration
Resp. viruses
inpatient (ICU) pneumonia - common pathogens Answer: S. pneumo
S. aureus
Legionella
Gram - bacilli
H. flu
initial treatment for outpatient CAP with no comorbidities and no risk factors for MRSA or
Pseudomonas Answer: Amoxicillin or doxy or macrolide (if local pneumococcal
resistance is <25%)
initial treatment for outpatient CAP with comorbidities Answer: combo therapy with
augmentin or cephalosporin AND macrolide or doxy
monotherapy w/ resp FQ (moxifloxacin, levofloxacin)
what are comorbidities that we should be careful of in CAP treatment Answer: chronic
heart, lung liver, or renal disease, diabetes, alcoholism, malignancy, asplenia
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
, what are risk factors for MRSA and/or pseudomonas we need to be careful of in treating
CAP Answer: prior respiratory isolation of MRSA or Pseudomonas or recent
hospitalization AND receipt of parenteral abx in the last 90 days
amoxicillin abx type Answer: beta lactam, PCN like
amoxicillin MOA Answer: inhibits bacterial cell wall synthesis by binding to one or more
PBPs
amoxicillin SE Answer: rash, n, d
amoxicillin concerns Answer: dose adjust in renal impairment
allergy
doxycycline abx type Answer: tetracycline
doxycycline MOA Answer: inhibits protein synthesis by binding w/ the 30S (and
possibly 50S) ribosomal subunits
doxycycline SE Answer: rash, photosensitivity, n, v, d, dysphagia, heartburn
doxycycline concerns Answer: don't use in those under 8 y/o --> causes tooth
hyperpigmentation, tooth enamel hypoplasia, permanent tooth discoloration
azithromycin abx type Answer: macrolide
azithromycin MOA Answer: inhibits RNA-dependent protein synthesis at the chain
elongation step by binding the 50S subunit
azithromycin SE Answer: abd pain, n, v, d, rash
azithromycin concerns Answer: growing resistance to S. pneumo
QT prolongation risk
caution in hepatic dysfunction
clarithromycin abx type Answer: macrolide
clarithromycin MOA Answer: inhibits RNA-dependent protein synthesis at chain
elongation step by binding to the 50S subunit
clarithromycin SE Answer: abd pain, v, d, dysgeusia, rash
clarithromycin conerns Answer: contraindicated in QT prolongation
CYP 3A4 inhibitor (DDI)
requires dose adjustment in renal impairment
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
