NR 507-ADVANCED PATHOPHYSIOLOGY: HYPERSENSITIVITY CORRECT 100%

NR 507-ADVANCED
PATHOPHYSIOLOGY:
HYPERSENSITIVITY CORRECT 100%
Hypersensitivity: Type 1 - ANSWERAllergic reaction

Hypersensitivity Type 1 is Mediated by - ANSWERIgE

Hypersensitivity Type 1 Inflammation - ANSWERmast cell degranulation

Hypersensitivity Type 1 Local symptoms - ANSWERitching, rash

Hypersensitivity Type 1 Systemic symptoms - ANSWERwheezing

Most dangerous type of Type 1 hypersensitivity - ANSWERanaphylactic reaction-
systemic response-hypotension, severe bronchoconstriction

Hypersensitivity: Type 2 - ANSWERCytotoxic reaction; tissue specific (e.g. thyroid
tissue)
-Antibodies bind to antigens on the cells surface
-IgG or IgM mediated
-Toxicity to the thyroid tissue
-Macrophages are primary effectors
-Tissue damage will occur, or function will be altered

Hypersensitivity Type 2 effectors cells - ANSWERMacrophages are primary

Hypersensitivity Type 2 Example - ANSWER-Blood type incompatibilities
-Graves disease


Hypersensitivity Type 3 antibody binds to the - ANSWERsoluble antigen outside the cell
surface that was released into the blood or body fluids, and the complex is then
deposited in the tissues.
- NOT organ specific

SLE As A Type 3 Hypersensitivity Reaction - ANSWER•Immune Complex Formation
•Tissue Deposition
•Inflammatory Response

SLE Flare-ups triggers - ANSWER- stress
- infections
- sunlight (UV exposure)