NR 565 ADVANCED PHARMACOLOGY MIDTERM CHAMBERLAIN
QUESTIONS AND CORRECT ANSWERS GRADED A+
QUESTION:
During what trimester is a pregnant woman most at risk for adverse drug reactions with
potential long-term consequences?
CORRECT ANSWER:
First trimester, when the fetus is most at risk due to rapid growth and organ development.
QUESTION:
What is the Beers Criteria?
CORRECT ANSWER:
A list of medications considered potentially inappropriate for older adults (65 and older); the
prescriber ultimately decides.
QUESTION:
What is the CYP450 (cytochrome P450) system?
CORRECT ANSWER:
A liver enzyme system where medications are metabolized; drugs can act as inducers or
inhibitors and cause drug–drug interactions.
QUESTION:
What are CYP450 inducers?
CORRECT ANSWER:
Drugs that speed up metabolism, leading to faster drug clearance, decreased blood levels, and
reduced drug effect.
,QUESTION:
What is a mnemonic for CYP450 inducers?
CORRECT ANSWER:
“Bullshit Crap GPS INDUCES rage”
QUESTION:
What are examples of CYP450 inducer drugs?
CORRECT ANSWER:
Barbiturates, St. John’s wort, carbamazepine, rifampin, alcohol, phenytoin, griseofulvin,
phenobarbital, and sulfonylureas.
QUESTION:
What are CYP450 inhibitors?
CORRECT ANSWER:
Drugs that inhibit metabolism, resulting in increased blood levels of medications.
QUESTION:
What is a mnemonic for CYP450 inhibitors?
CORRECT ANSWER:
“VISA credit card debt INHIBITS spending on designers like CK to look GQ”
QUESTION:
What are examples of CYP450 inhibitor drugs?
CORRECT ANSWER:
Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit
juice, and quinidine.
QUESTION:
What physiological changes during pregnancy affect pharmacokinetics and pharmacodynamics
of drugs?
, CORRECT ANSWER:
Increased glomerular filtration rate causing increased drug excretion, increased hepatic
metabolism, decreased bowel tone and motility, and increased drug absorption.
QUESTION:
What are examples of medications that can be teratogenic?
CORRECT ANSWER:
Antiepileptic drugs, tetracyclines, fluoroquinolones, high-dose vitamin A, some anticoagulants,
and hormonal drugs such as diethylstilbestrol (DES).
QUESTION:
How is absorption of intramuscular medications different in neonates?
CORRECT ANSWER:
Absorption is slow and erratic due to low muscle blood flow during the first few days of life.
QUESTION:
Why is absorption of medication in the stomach increased in infancy
CORRECT ANSWER:
Delayed gastric emptying.
QUESTION:
Which medications should be avoided in pediatric patients?
CORRECT ANSWER:
Glucocorticoids, tetracyclines (tooth discoloration), sulfonamides (risk of kernicterus),
levofloxacin, and aspirin due to risk of severe intoxication.
QUESTION:
What should be included in medication administration patient education?
CORRECT ANSWER:
Dosage size and timing, route and technique, duration of treatment, storage, desired effects,
adverse effects, and the importance of completing antibiotics.
QUESTIONS AND CORRECT ANSWERS GRADED A+
QUESTION:
During what trimester is a pregnant woman most at risk for adverse drug reactions with
potential long-term consequences?
CORRECT ANSWER:
First trimester, when the fetus is most at risk due to rapid growth and organ development.
QUESTION:
What is the Beers Criteria?
CORRECT ANSWER:
A list of medications considered potentially inappropriate for older adults (65 and older); the
prescriber ultimately decides.
QUESTION:
What is the CYP450 (cytochrome P450) system?
CORRECT ANSWER:
A liver enzyme system where medications are metabolized; drugs can act as inducers or
inhibitors and cause drug–drug interactions.
QUESTION:
What are CYP450 inducers?
CORRECT ANSWER:
Drugs that speed up metabolism, leading to faster drug clearance, decreased blood levels, and
reduced drug effect.
,QUESTION:
What is a mnemonic for CYP450 inducers?
CORRECT ANSWER:
“Bullshit Crap GPS INDUCES rage”
QUESTION:
What are examples of CYP450 inducer drugs?
CORRECT ANSWER:
Barbiturates, St. John’s wort, carbamazepine, rifampin, alcohol, phenytoin, griseofulvin,
phenobarbital, and sulfonylureas.
QUESTION:
What are CYP450 inhibitors?
CORRECT ANSWER:
Drugs that inhibit metabolism, resulting in increased blood levels of medications.
QUESTION:
What is a mnemonic for CYP450 inhibitors?
CORRECT ANSWER:
“VISA credit card debt INHIBITS spending on designers like CK to look GQ”
QUESTION:
What are examples of CYP450 inhibitor drugs?
CORRECT ANSWER:
Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit
juice, and quinidine.
QUESTION:
What physiological changes during pregnancy affect pharmacokinetics and pharmacodynamics
of drugs?
, CORRECT ANSWER:
Increased glomerular filtration rate causing increased drug excretion, increased hepatic
metabolism, decreased bowel tone and motility, and increased drug absorption.
QUESTION:
What are examples of medications that can be teratogenic?
CORRECT ANSWER:
Antiepileptic drugs, tetracyclines, fluoroquinolones, high-dose vitamin A, some anticoagulants,
and hormonal drugs such as diethylstilbestrol (DES).
QUESTION:
How is absorption of intramuscular medications different in neonates?
CORRECT ANSWER:
Absorption is slow and erratic due to low muscle blood flow during the first few days of life.
QUESTION:
Why is absorption of medication in the stomach increased in infancy
CORRECT ANSWER:
Delayed gastric emptying.
QUESTION:
Which medications should be avoided in pediatric patients?
CORRECT ANSWER:
Glucocorticoids, tetracyclines (tooth discoloration), sulfonamides (risk of kernicterus),
levofloxacin, and aspirin due to risk of severe intoxication.
QUESTION:
What should be included in medication administration patient education?
CORRECT ANSWER:
Dosage size and timing, route and technique, duration of treatment, storage, desired effects,
adverse effects, and the importance of completing antibiotics.
