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ATI PHARMACOLOGY PROCTORED EXAM
(100 QUESTIONS WITH ANSWERS) 2026 JUST
RELEASED VERSION
SECTION I: GENERAL PHARMACOLOGY (1–20)
1. Which medication classification inhibits bacterial cell wall
synthesis?
A. Macrolides
B. Cephalosporins
C. Tetracyclines
D. Aminoglycosides
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Answer: B. Cephalosporins
Rationale: Cephalosporins interfere with bacterial cell wall
synthesis, leading to lysis.
2. A patient on digoxin develops nausea, vomiting, and
bradycardia. What is the most likely cause?
A. Hypokalemia
B. Digoxin toxicity
C. Hypernatremia
D. Hypocalcemia
Answer: B. Digoxin toxicity
Rationale: GI symptoms and bradycardia are classic signs of
digoxin toxicity; monitor levels and electrolytes.
3. Which drug class is first-line for hypertension in a patient
with diabetes?
A. ACE inhibitors
B. Beta-blockers
C. Calcium channel blockers
D. Diuretics
Answer: A. ACE inhibitors
Rationale: ACE inhibitors protect the kidneys and lower BP
effectively in diabetics.
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4. Patient receiving IV vancomycin develops flushing and
hypotension. What is this reaction called?
A. Anaphylaxis
B. Red man syndrome
C. Serum sickness
D. Stevens-Johnson syndrome
Answer: B. Red man syndrome
Rationale: Rapid infusion causes histamine release leading to
red man syndrome; slow infusion and pre-medicate with
antihistamine.
5. Which class of drugs blocks H₂ receptors to reduce gastric
acid secretion?
A. Proton pump inhibitors
B. H₂ receptor antagonists
C. Antacids
D. Prokinetic agents
Answer: B. H₂ receptor antagonists
Rationale: H₂ blockers competitively inhibit H₂ receptors on
parietal cells, reducing acid secretion.
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6. A patient is prescribed amiodarone. Which lab should be
monitored regularly?
A. Liver function tests
B. BUN and creatinine
C. CBC only
D. Lipid panel
Answer: A. Liver function tests
Rationale: Amiodarone is hepatotoxic; monitor liver enzymes
regularly.
7. Which medication is used to reverse benzodiazepine
overdose?
A. Naloxone
B. Flumazenil
C. Protamine sulfate
D. Vitamin K
Answer: B. Flumazenil
Rationale: Flumazenil antagonizes benzodiazepine receptors in
the CNS.
8. Which of the following drugs is teratogenic?
A. Lisinopril
B. Metformin
ATI PHARMACOLOGY PROCTORED EXAM
(100 QUESTIONS WITH ANSWERS) 2026 JUST
RELEASED VERSION
SECTION I: GENERAL PHARMACOLOGY (1–20)
1. Which medication classification inhibits bacterial cell wall
synthesis?
A. Macrolides
B. Cephalosporins
C. Tetracyclines
D. Aminoglycosides
,2
Answer: B. Cephalosporins
Rationale: Cephalosporins interfere with bacterial cell wall
synthesis, leading to lysis.
2. A patient on digoxin develops nausea, vomiting, and
bradycardia. What is the most likely cause?
A. Hypokalemia
B. Digoxin toxicity
C. Hypernatremia
D. Hypocalcemia
Answer: B. Digoxin toxicity
Rationale: GI symptoms and bradycardia are classic signs of
digoxin toxicity; monitor levels and electrolytes.
3. Which drug class is first-line for hypertension in a patient
with diabetes?
A. ACE inhibitors
B. Beta-blockers
C. Calcium channel blockers
D. Diuretics
Answer: A. ACE inhibitors
Rationale: ACE inhibitors protect the kidneys and lower BP
effectively in diabetics.
,3
4. Patient receiving IV vancomycin develops flushing and
hypotension. What is this reaction called?
A. Anaphylaxis
B. Red man syndrome
C. Serum sickness
D. Stevens-Johnson syndrome
Answer: B. Red man syndrome
Rationale: Rapid infusion causes histamine release leading to
red man syndrome; slow infusion and pre-medicate with
antihistamine.
5. Which class of drugs blocks H₂ receptors to reduce gastric
acid secretion?
A. Proton pump inhibitors
B. H₂ receptor antagonists
C. Antacids
D. Prokinetic agents
Answer: B. H₂ receptor antagonists
Rationale: H₂ blockers competitively inhibit H₂ receptors on
parietal cells, reducing acid secretion.
, 4
6. A patient is prescribed amiodarone. Which lab should be
monitored regularly?
A. Liver function tests
B. BUN and creatinine
C. CBC only
D. Lipid panel
Answer: A. Liver function tests
Rationale: Amiodarone is hepatotoxic; monitor liver enzymes
regularly.
7. Which medication is used to reverse benzodiazepine
overdose?
A. Naloxone
B. Flumazenil
C. Protamine sulfate
D. Vitamin K
Answer: B. Flumazenil
Rationale: Flumazenil antagonizes benzodiazepine receptors in
the CNS.
8. Which of the following drugs is teratogenic?
A. Lisinopril
B. Metformin
