The semi conservative model suggests that the original DNA molecule splits into two separate
strands that new nucleotides fill in the opposite chain.
DNA replication occurs on multiple origins of replication along the DNA template strand. As the DNA
double helix is unwound by helicase, replication occurs separately on each template strand in
antiparallel directions. This process is known as semi-conservative replication because two
copies of the original DNA molecule are produced.
IT OCCURS DURING THE SYNTHESIS (S - DNA
REPLICATION) OF INTERPHASE
Semi-conservative replication
1. DNA helicase enzyme breaks hydrogen bonds between
base pairs.
2. Double helix unwinds.
3. Exposed polynucleotide strand acts as template.
4. Complementary base pairing occurs as free floating
nucleotides attach to complementary exposed bases.
5. Nucleotides joined together via condensation reaction by
DNA polymerase.
, EVIDENCE FOR SEMI CONSERVATIVE DNA REPLICATION
strands that new nucleotides fill in the opposite chain.
DNA replication occurs on multiple origins of replication along the DNA template strand. As the DNA
double helix is unwound by helicase, replication occurs separately on each template strand in
antiparallel directions. This process is known as semi-conservative replication because two
copies of the original DNA molecule are produced.
IT OCCURS DURING THE SYNTHESIS (S - DNA
REPLICATION) OF INTERPHASE
Semi-conservative replication
1. DNA helicase enzyme breaks hydrogen bonds between
base pairs.
2. Double helix unwinds.
3. Exposed polynucleotide strand acts as template.
4. Complementary base pairing occurs as free floating
nucleotides attach to complementary exposed bases.
5. Nucleotides joined together via condensation reaction by
DNA polymerase.
, EVIDENCE FOR SEMI CONSERVATIVE DNA REPLICATION
