Goodman and Gilman's The
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
All content is confined to concepts, terminology, and
emphasis used in this chapter only.
,No external sources, clinical guidelines, or nursing review
materials were used.
Goodman & Gilman–Only Nursing Pharmacology Test
Bank
Chapter: Drug Discovery – From Medicinal Plants to
Computer-Aided Drug Design
1.
Which historical approach to drug discovery involved
empirical observation of therapeutic effects from natural
sources?
A. High-throughput screening
B. Rational drug design
C. Ethnopharmacology
D. Structure-based ligand optimization
Correct Answer: C
Rationale: Ethnopharmacology relies on traditional
medicinal practices and empirical observations of plants
and natural substances to identify biologically active
compounds.
,Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
2.
Which characteristic of natural products has historically
made them valuable leads for drug development?
A. Predictable pharmacokinetics
B. Structural diversity and biological activity
C. Ease of large-scale synthesis
D. Minimal adverse effects
Correct Answer: B
Rationale: Natural products often possess complex and
diverse chemical structures that interact with biological
targets, making them useful starting points for drug
discovery.
Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
3.
What is the primary limitation of natural products in
modern drug development?
, A. Lack of receptor specificity
B. High toxicity
C. Difficulty in isolation, synthesis, and modification
D. Short duration of action
Correct Answer: C
Rationale: The chapter emphasizes challenges such as
limited availability, complex structures, and difficulty in
chemical modification of natural compounds.
Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
4.
High-throughput screening (HTS) is best described as:
A. Testing a single compound against multiple diseases
B. Screening thousands of compounds rapidly against a
biological target
C. Predicting drug–drug interactions
D. Evaluating pharmacokinetics in humans
Correct Answer: B
Rationale: HTS allows rapid experimental testing of large
compound libraries against specific biological targets to
identify active “hits.”
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
All content is confined to concepts, terminology, and
emphasis used in this chapter only.
,No external sources, clinical guidelines, or nursing review
materials were used.
Goodman & Gilman–Only Nursing Pharmacology Test
Bank
Chapter: Drug Discovery – From Medicinal Plants to
Computer-Aided Drug Design
1.
Which historical approach to drug discovery involved
empirical observation of therapeutic effects from natural
sources?
A. High-throughput screening
B. Rational drug design
C. Ethnopharmacology
D. Structure-based ligand optimization
Correct Answer: C
Rationale: Ethnopharmacology relies on traditional
medicinal practices and empirical observations of plants
and natural substances to identify biologically active
compounds.
,Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
2.
Which characteristic of natural products has historically
made them valuable leads for drug development?
A. Predictable pharmacokinetics
B. Structural diversity and biological activity
C. Ease of large-scale synthesis
D. Minimal adverse effects
Correct Answer: B
Rationale: Natural products often possess complex and
diverse chemical structures that interact with biological
targets, making them useful starting points for drug
discovery.
Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
3.
What is the primary limitation of natural products in
modern drug development?
, A. Lack of receptor specificity
B. High toxicity
C. Difficulty in isolation, synthesis, and modification
D. Short duration of action
Correct Answer: C
Rationale: The chapter emphasizes challenges such as
limited availability, complex structures, and difficulty in
chemical modification of natural compounds.
Citation: Goodman & Gilman, 14th ed., Drug Discovery:
From Medicinal Plants to Computer-Aided Drug Design
4.
High-throughput screening (HTS) is best described as:
A. Testing a single compound against multiple diseases
B. Screening thousands of compounds rapidly against a
biological target
C. Predicting drug–drug interactions
D. Evaluating pharmacokinetics in humans
Correct Answer: B
Rationale: HTS allows rapid experimental testing of large
compound libraries against specific biological targets to
identify active “hits.”
