Goodman and Gilman's The
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter 1: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
(Brunton & Knollmann)
,Nursing Pharmacology Test Bank
Chapter 1 – Drug Discovery
EXACTLY 20 MCQs
1.
Which historical source contributed most directly to the earliest
identification of pharmacologically active compounds?
A. Randomized clinical trials
B. Medicinal plants used in traditional medicine
C. Synthetic chemical libraries
D. High-throughput screening platforms
Correct Answer: B
Rationale: Goodman & Gilman emphasizes that many early
drugs were discovered from medicinal plants used in
traditional medicine, which provided biologically active
compounds later isolated and studied.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
2.
Which property of natural products has made them particularly
valuable in early drug discovery?
,A. Predictable pharmacokinetics
B. Structural simplicity
C. Chemical diversity and biological activity
D. Ease of large-scale synthesis
Correct Answer: C
Rationale: The text highlights that natural products possess
high chemical diversity and inherent biological activity, making
them valuable starting points for drug discovery.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
3.
In modern drug discovery, which approach involves designing
compounds based on the known structure of a biological
target?
A. Phenotypic screening
B. Empirical pharmacology
C. Structure-based drug design
D. Postmarketing surveillance
Correct Answer: C
Rationale: Goodman & Gilman describes structure-based drug
design as using the three-dimensional structure of a target
(e.g., receptor or enzyme) to design ligands.
, Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
4.
Which technology allows rapid testing of thousands of
compounds against a biological target?
A. Phase I clinical trials
B. High-throughput screening
C. Computer-aided molecular docking
D. Pharmacovigilance databases
Correct Answer: B
Rationale: High-throughput screening is described as a key
modern method allowing rapid evaluation of large compound
libraries for biological activity.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
5.
Which step in drug discovery typically occurs before preclinical
animal testing?
A. Phase II trials
B. Lead compound optimization
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter 1: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
(Brunton & Knollmann)
,Nursing Pharmacology Test Bank
Chapter 1 – Drug Discovery
EXACTLY 20 MCQs
1.
Which historical source contributed most directly to the earliest
identification of pharmacologically active compounds?
A. Randomized clinical trials
B. Medicinal plants used in traditional medicine
C. Synthetic chemical libraries
D. High-throughput screening platforms
Correct Answer: B
Rationale: Goodman & Gilman emphasizes that many early
drugs were discovered from medicinal plants used in
traditional medicine, which provided biologically active
compounds later isolated and studied.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
2.
Which property of natural products has made them particularly
valuable in early drug discovery?
,A. Predictable pharmacokinetics
B. Structural simplicity
C. Chemical diversity and biological activity
D. Ease of large-scale synthesis
Correct Answer: C
Rationale: The text highlights that natural products possess
high chemical diversity and inherent biological activity, making
them valuable starting points for drug discovery.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
3.
In modern drug discovery, which approach involves designing
compounds based on the known structure of a biological
target?
A. Phenotypic screening
B. Empirical pharmacology
C. Structure-based drug design
D. Postmarketing surveillance
Correct Answer: C
Rationale: Goodman & Gilman describes structure-based drug
design as using the three-dimensional structure of a target
(e.g., receptor or enzyme) to design ligands.
, Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
4.
Which technology allows rapid testing of thousands of
compounds against a biological target?
A. Phase I clinical trials
B. High-throughput screening
C. Computer-aided molecular docking
D. Pharmacovigilance databases
Correct Answer: B
Rationale: High-throughput screening is described as a key
modern method allowing rapid evaluation of large compound
libraries for biological activity.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
5.
Which step in drug discovery typically occurs before preclinical
animal testing?
A. Phase II trials
B. Lead compound optimization
