FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY ADMINISTRATION COMPREHENSIVE TEST PAPER 2026

FUNDAMENTALS OF CHEMOTHERAPY
IMMUNOTHERAPY ADMINISTRATION
COMPREHENSIVE TEST PAPER 2026

◉ What are alkylating agents. Answer: -cell cycle nonspecific
-damage DNA to prevent cancer cells from reproducing
-create breaks in DNA


◉ Cyclophosphamide. Answer: -alkylating agent
-treats: leukemia, lymphoma, breast/ovarian CA, myeloma,
neuroblastoma, mycosis fungoides, retinoblastoma.
-IV, oral, peritoneal
-important to hydrate, prevent hemorrhagic cystitis


◉ Cisplatin?. Answer: -alkylating agent
-treats: bladder, testes, ovaries, endometrial, lung, squamous cell of
head/neck
-IV, peritoneal
-high N/V
-no aluminum PIV
-hearing loss and peripheral neuropathy with long term use

, ◉ Carboplatin?. Answer: -alkylating agent
-treats: ovarian and off-label use
-IV only
-dose calculated using calvert formula
-no aluminum PIV


◉ Oxaliplatin. Answer: -alyklating agent
-with 5-fluorouracil/leucovorin
-Adjuvant treatment: colorectal, testicular, esophageal, pancreatic,
gastric, hepatobillary, ovarian, lymphoma
-IV only
-premed with anti-emetic and dexamethasone


◉ Antimetabolites. Answer: -stops cells from using folic acid to make
DNA (S phase)
-Kills cancer cells
-cause myelosuppression, N/V, mucositis, GI toxicity


◉ Methotrexate. Answer: -Antimetabolites
-treats: leukemia, lung, breast, head/neck, lymphoma, mycosis
fungoides, choriocarcinoma, osteogenic sarcoma
-OFF-LABEL: bladder CA, immunosuppression, psoriasis, RA, post-
hematopoietic stem cell transplant