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Osteoporosis - CORRECT ANSWER - Progressive loss of bone mass.
Increased risk for fractures. Type 1 occurs primarily in post menopausal women.
Type 2 is men and women. Can be caused by other diseases or medications.
Such as oasis, steroids, heparin, etc.
osteomalacia - CORRECT ANSWER - Softening of the bone. Adults version
of rickets. Low vitamin D. Can also be caused by hyperparathryoidism. Nirmal
vitamin d level is 20-80.
Paget Disease - CORRECT ANSWER - Disorder of bone remodeling.
Typically occurs in one or more bones. They tend to have a high alkaline
phosphate level.
Treatment for Paget's Disease - CORRECT ANSWER - Zoledronic acid.
Given once a year via IV infusion. Also prescribed a high dose biphosphonate
and calcitonin.
Treatment for osteomalacia - CORRECT ANSWER - vitamin D and calcium.
Give calcitriol is vitamin d level is less than 10
Bisphosphonates - CORRECT ANSWER - -dronate given for treatment of
osteoporosis, pagets, and osteomalacia
Fosamax (alendronate) - CORRECT ANSWER - Classification: Bone
resorption inhibitor. Bisphosphonate
, Therapeutic Effects: TX and prevention of post-menopausal and cortico-steroid-
induced osteoporosis,
Adverse Reactions & side effects: Altered taste, photosensitivity, rash,
musculoskeletal pain, fluid overload, esophagitis. Common upset stomach &
heartburn, GI effects
Nursing Implications & teaching:Take first thing in the AM, before eating
anything; then pt MUST remain upright for at least 30 mins! Take only with
plain water. Monitor for GI side effects. Use sunscreen to prevent
photosensitivity reactions. Do not give to those with Renal insufficiency
Raloxifene (Evista) - CORRECT ANSWER - Selective Estrogen Receptor
Modulator (SERM) Osteoporosis. Give daily. For those that are intolerant to
bisphosphonates. Can cause hot flashes. Don't give to those with a history of
DVT, stroke, MI. Can lower LDL. Has estrogen side effects. Do not give if at a
high risk for uterine or breast cancer.
Duavee (conjugated estrogens/bazedoxifene) - CORRECT ANSWER - First
drug to combine estrogen with an estrogen agonist/antagonist (bazedoxifene)
Drug should be used for the shortest duration possible. Do not give to patient is
they have a uterus or previous DVT, stroke, MI, PE.
Calcitonin (Miacalcin) - CORRECT ANSWER - nasal spray to decrease bone
loss from osteoporosis; instruct pt. to alternate nostrils each day when
administering the nasal spray to decrease rhinitis. Can cause nose bleeds. Does
not affect osteoporosis of the hip.
Teriparatide (Forteo) - CORRECT ANSWER - Given for osteoporosis. Only
drug that will build bone by stimulating osteoblast (building of bone). Given
subQ for up to two years. No longer than two years. After two years give a
bisphonphosate.
Denosumab (Prolia) - CORRECT ANSWER - RANKL-inhibitor
SQ every 6 months (Osteoporosis)