Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines the practice of medicine as
described in Harrison’s?
A. Application of standardized protocols
B. Integration of scientific evidence with clinical judgment and
patient values
C. Reliance on diagnostic technology
D. Disease-centered decision-making
Correct Answer: B
Rationale: Harrison’s emphasizes medicine as a balance of
,science, clinical expertise, and patient-centered values—not
protocols alone.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 The Practice of Medicine
2. A nurse counseling a patient on health promotion should
prioritize which strategy for greatest population-level impact?
A. Pharmacologic prevention
B. Individual genetic screening
C. Lifestyle and behavioral modification
D. Advanced imaging screening
Correct Answer: C
Rationale: Harrison’s identifies behavior and lifestyle
interventions as the most impactful determinants of health
outcomes.
Citation: Harrison’s, 22nd ed., Ch. 2 Promoting Good Health
3. Vaccine hesitancy most commonly stems from which factor?
A. Cost barriers
B. Religious prohibition
C. Mistrust and misinformation
D. Lack of provider access
Correct Answer: C
Rationale: Harrison’s highlights misinformation and erosion of
,trust as primary drivers of vaccine opposition.
Citation: Harrison’s, 22nd ed., Ch. 3 Vaccine Opposition and
Hesitancy
4. Which nursing action best supports shared clinical decision-
making?
A. Providing clinician-directed instructions
B. Presenting risks, benefits, and alternatives clearly
C. Limiting patient involvement to consent
D. Deferring decisions to clinical algorithms
Correct Answer: B
Rationale: Shared decision-making requires transparent
communication of options aligned with patient preferences.
Citation: Harrison’s, 22nd ed., Ch. 4 Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Individualize care using genetic, environmental, and lifestyle
data
C. Reduce healthcare costs
D. Eliminate clinical judgment
Correct Answer: B
Rationale: Harrison’s defines precision medicine as tailoring
, care to individual variability.
Citation: Harrison’s, 22nd ed., Ch. 5 Precision Medicine and
Clinical Care
6. A key nursing implication of disease screening programs is:
A. Screening guarantees improved outcomes
B. Earlier detection always reduces mortality
C. Awareness of false positives and overdiagnosis
D. Screening replaces clinical assessment
Correct Answer: C
Rationale: Harrison’s cautions that screening carries risks
including overdiagnosis and psychological harm.
Citation: Harrison’s, 22nd ed., Ch. 6 Screening and Prevention of
Disease
7. Which factor most strongly contributes to preventable
patient harm?
A. Individual clinician negligence
B. System-level process failures
C. Patient nonadherence
D. Lack of advanced technology
Correct Answer: B
Rationale: Harrison’s frames patient safety as primarily a
systems issue rather than individual blame.
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines the practice of medicine as
described in Harrison’s?
A. Application of standardized protocols
B. Integration of scientific evidence with clinical judgment and
patient values
C. Reliance on diagnostic technology
D. Disease-centered decision-making
Correct Answer: B
Rationale: Harrison’s emphasizes medicine as a balance of
,science, clinical expertise, and patient-centered values—not
protocols alone.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 The Practice of Medicine
2. A nurse counseling a patient on health promotion should
prioritize which strategy for greatest population-level impact?
A. Pharmacologic prevention
B. Individual genetic screening
C. Lifestyle and behavioral modification
D. Advanced imaging screening
Correct Answer: C
Rationale: Harrison’s identifies behavior and lifestyle
interventions as the most impactful determinants of health
outcomes.
Citation: Harrison’s, 22nd ed., Ch. 2 Promoting Good Health
3. Vaccine hesitancy most commonly stems from which factor?
A. Cost barriers
B. Religious prohibition
C. Mistrust and misinformation
D. Lack of provider access
Correct Answer: C
Rationale: Harrison’s highlights misinformation and erosion of
,trust as primary drivers of vaccine opposition.
Citation: Harrison’s, 22nd ed., Ch. 3 Vaccine Opposition and
Hesitancy
4. Which nursing action best supports shared clinical decision-
making?
A. Providing clinician-directed instructions
B. Presenting risks, benefits, and alternatives clearly
C. Limiting patient involvement to consent
D. Deferring decisions to clinical algorithms
Correct Answer: B
Rationale: Shared decision-making requires transparent
communication of options aligned with patient preferences.
Citation: Harrison’s, 22nd ed., Ch. 4 Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Individualize care using genetic, environmental, and lifestyle
data
C. Reduce healthcare costs
D. Eliminate clinical judgment
Correct Answer: B
Rationale: Harrison’s defines precision medicine as tailoring
, care to individual variability.
Citation: Harrison’s, 22nd ed., Ch. 5 Precision Medicine and
Clinical Care
6. A key nursing implication of disease screening programs is:
A. Screening guarantees improved outcomes
B. Earlier detection always reduces mortality
C. Awareness of false positives and overdiagnosis
D. Screening replaces clinical assessment
Correct Answer: C
Rationale: Harrison’s cautions that screening carries risks
including overdiagnosis and psychological harm.
Citation: Harrison’s, 22nd ed., Ch. 6 Screening and Prevention of
Disease
7. Which factor most strongly contributes to preventable
patient harm?
A. Individual clinician negligence
B. System-level process failures
C. Patient nonadherence
D. Lack of advanced technology
Correct Answer: B
Rationale: Harrison’s frames patient safety as primarily a
systems issue rather than individual blame.
