NURS 5334 ADVANCED PHARMACOLOGY
FULL QUESTION SET & PREDICTIVE EXAM
CURRENT EDITION 2026.
◍ Absorption.Answer:Enteral route involves the GI system (oral)
Parenteral route = IV, IM
Transdermal = through the skin
Respiratory = droplet, inhalation
◍ Distribution.Answer:Amount of drug in the body divided by the
plasma drug concentration.
◍ Factors effecting distribution.Answer:Blood flow, lipid solubility,
molecular size of the drug, plasma proteins (very important)
◍ Volume of distribution.Answer:Vd = amount of drug in the body
divided by the amount of drug in the plasma divided by
bioavailability.
◍ Bioavailability.Answer:How much drug makes it into the system.
Must account for absorption and extraction.
◍ Extraction.Answer:How much of the drugs bioavailability can be
used by the body.
, ◍ **IV route dosing (parenteral).Answer:Goes directly to the body.
Results in 100% bioavailability. Decreasing first pass effect,
decreasing absorption limitations, extractions...
By passes absorption and extraction.
◍ Loading dose.Answer:[Peak] concentration X Vd divided by
bioavailability
◍ Maintenance dose.Answer:[Peak] X Clearance divided by
bioavailability
◍ Clearance is affected by.Answer:Kidney function
◍ **If a patient has kidney disease you would.Answer:Decrease your
maintenance dose; loading dose stays the same (doesn't affect
clearance)
◍ Metabolism.Answer:
◍ Phase 1 reaction.Answer:Oxidation, reduction, hydrolytic (CYP450
system in the liver) Zone 3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
◍ Phase 2 reaction.Answer:Gluceronudation, acetylation, sulfation
(inactive metabolites)
FULL QUESTION SET & PREDICTIVE EXAM
CURRENT EDITION 2026.
◍ Absorption.Answer:Enteral route involves the GI system (oral)
Parenteral route = IV, IM
Transdermal = through the skin
Respiratory = droplet, inhalation
◍ Distribution.Answer:Amount of drug in the body divided by the
plasma drug concentration.
◍ Factors effecting distribution.Answer:Blood flow, lipid solubility,
molecular size of the drug, plasma proteins (very important)
◍ Volume of distribution.Answer:Vd = amount of drug in the body
divided by the amount of drug in the plasma divided by
bioavailability.
◍ Bioavailability.Answer:How much drug makes it into the system.
Must account for absorption and extraction.
◍ Extraction.Answer:How much of the drugs bioavailability can be
used by the body.
, ◍ **IV route dosing (parenteral).Answer:Goes directly to the body.
Results in 100% bioavailability. Decreasing first pass effect,
decreasing absorption limitations, extractions...
By passes absorption and extraction.
◍ Loading dose.Answer:[Peak] concentration X Vd divided by
bioavailability
◍ Maintenance dose.Answer:[Peak] X Clearance divided by
bioavailability
◍ Clearance is affected by.Answer:Kidney function
◍ **If a patient has kidney disease you would.Answer:Decrease your
maintenance dose; loading dose stays the same (doesn't affect
clearance)
◍ Metabolism.Answer:
◍ Phase 1 reaction.Answer:Oxidation, reduction, hydrolytic (CYP450
system in the liver) Zone 3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
◍ Phase 2 reaction.Answer:Gluceronudation, acetylation, sulfation
(inactive metabolites)
