neurotransmi ers involved with depression -correct answers serotonin (5-HT), norepinephrine,
epinephrine, dopamine, glutamate, and acetylcholine
drugs that can worsen depression -correct answers atomoxe ne (stra era), indomethacin,
efavirenz, rilpivirine, beta blockers, hormonal contracep ves, anabolic steroids
depression diagnosis -correct answers relies on systom assessment according to DSM-5;
Hamilton depression ra ng scale is some mes used
DSM-5 depression criteria (5 of the following during the same two week period) -correct
answers mood-depressed, sleep increased or decreased, interest/pleasure diminished, guilt or
feeling of worthlessness, energy decreased, concentra on decreased, appe te increased or
decreased, psychomotor agita on or retarda on, suicidal idea on
natural products for depression -correct answers st.johns wort, SAMe, valerian or 5-HTP
first line treatment for depression -correct answers CBT
medica on for most depressed pa ents -correct answers SSRI or SNRI
increase 5-HT by inhibi ng its reuptake in the neuronal synapse -correct answers selec ve
serotonin reuptake inhibitors (SSRIs)
,SSRIs contraindica ons -correct answers do not use with MAO inhibitors, linezolid, IV methylene
blue or pimozide
Brisdelle -correct answers SSRI do not use in pregnancy
SSRIs warnings -correct answers QT prolonga on, SIADH/hypoatremia, fall risk, bleeding
SSRIs side effects -correct answers sexual side effects (decreased libido, ejacula on difficul es,
anorgasmia, erec le dysfunc on), somnolence, insomnia, nausea, dry mouth, diaphoresis,
weakness, tremor, dizziness, HA
Most ac va ng SSRI -correct answers fluoxe ne take in the am
most seda ng SSRI -correct answers paroxe ne take in the pm
SSRI preferred in pa ents with cardiac risk -correct answers sertraline
citalopram (celexa) -correct answers SSRIs
escitalopram (lexapro) -correct answers SSRIs
fluoxe ne (prozac, sarafem) -correct answers SSRIs
paroxe ne (pail, brisdelle) -correct answers SSRIs
sertraline (zolfot) -correct answers SSRIs
, Fluvoxamine -correct answers SSRIs
increase 5-HT by inhibi ng its reuptake in the neuronal synapse and inhibit reuptake of
norepinephrine -correct answers SNRIs
venlafaxine (effexor XR) -correct answers SNRIs
duloxe ne (cymbalta, drixalma sprinkle) -correct answers SNRIs
desvenlafaxine (pris q) -correct answers SNRIs
levomilnacipran (fetzima) -correct answers SNRIs
SNRIs combined with what can lead to hypertensive crisis -correct answers MAO inhibitors
(contraindica on)
SNRIs warnings -correct answers SIADH/ hypoatremia, fall risk, bleeding
Levomilnacipran -correct answers do not use with CrCl < 15
duloxe ne -correct answers do not use with CrCl < 30
SNRI side effects -correct answers increased HR, dilated pupils, dry mouth, excessive swea ng
and cons pa on, increased blood pressure, osteopenia/osteoporosis, restless leg syndrome
inhibit NE and 5-HT reuptake, they also block Ach and histamine receptors -correct answers
tricyclic an depressants
epinephrine, dopamine, glutamate, and acetylcholine
drugs that can worsen depression -correct answers atomoxe ne (stra era), indomethacin,
efavirenz, rilpivirine, beta blockers, hormonal contracep ves, anabolic steroids
depression diagnosis -correct answers relies on systom assessment according to DSM-5;
Hamilton depression ra ng scale is some mes used
DSM-5 depression criteria (5 of the following during the same two week period) -correct
answers mood-depressed, sleep increased or decreased, interest/pleasure diminished, guilt or
feeling of worthlessness, energy decreased, concentra on decreased, appe te increased or
decreased, psychomotor agita on or retarda on, suicidal idea on
natural products for depression -correct answers st.johns wort, SAMe, valerian or 5-HTP
first line treatment for depression -correct answers CBT
medica on for most depressed pa ents -correct answers SSRI or SNRI
increase 5-HT by inhibi ng its reuptake in the neuronal synapse -correct answers selec ve
serotonin reuptake inhibitors (SSRIs)
,SSRIs contraindica ons -correct answers do not use with MAO inhibitors, linezolid, IV methylene
blue or pimozide
Brisdelle -correct answers SSRI do not use in pregnancy
SSRIs warnings -correct answers QT prolonga on, SIADH/hypoatremia, fall risk, bleeding
SSRIs side effects -correct answers sexual side effects (decreased libido, ejacula on difficul es,
anorgasmia, erec le dysfunc on), somnolence, insomnia, nausea, dry mouth, diaphoresis,
weakness, tremor, dizziness, HA
Most ac va ng SSRI -correct answers fluoxe ne take in the am
most seda ng SSRI -correct answers paroxe ne take in the pm
SSRI preferred in pa ents with cardiac risk -correct answers sertraline
citalopram (celexa) -correct answers SSRIs
escitalopram (lexapro) -correct answers SSRIs
fluoxe ne (prozac, sarafem) -correct answers SSRIs
paroxe ne (pail, brisdelle) -correct answers SSRIs
sertraline (zolfot) -correct answers SSRIs
, Fluvoxamine -correct answers SSRIs
increase 5-HT by inhibi ng its reuptake in the neuronal synapse and inhibit reuptake of
norepinephrine -correct answers SNRIs
venlafaxine (effexor XR) -correct answers SNRIs
duloxe ne (cymbalta, drixalma sprinkle) -correct answers SNRIs
desvenlafaxine (pris q) -correct answers SNRIs
levomilnacipran (fetzima) -correct answers SNRIs
SNRIs combined with what can lead to hypertensive crisis -correct answers MAO inhibitors
(contraindica on)
SNRIs warnings -correct answers SIADH/ hypoatremia, fall risk, bleeding
Levomilnacipran -correct answers do not use with CrCl < 15
duloxe ne -correct answers do not use with CrCl < 30
SNRI side effects -correct answers increased HR, dilated pupils, dry mouth, excessive swea ng
and cons pa on, increased blood pressure, osteopenia/osteoporosis, restless leg syndrome
inhibit NE and 5-HT reuptake, they also block Ach and histamine receptors -correct answers
tricyclic an depressants
