Medical-Surgical Nursing MCQ Test Bank — Fast-Revision Study Guide for ADN/BSN,

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics



1. A 68-year-old patient with multiple chronic conditions asks
whether the physician’s plan should focus primarily on
disease-specific targets or on the patient’s overall goals
and functional status. Which principle best reflects current
best practice in “The Practice of Medicine”?
A. Rigid adherence to disease-specific targets for all
patients
B. Prioritizing patient goals and individualized care plans
C. Applying the same guideline algorithms regardless of
comorbidity
D. Prioritizing diagnostic testing before discussing goals
Correct: B
Rationale: Modern practice emphasizes patient-centered
care that aligns management with the patient’s values,
prognosis, and functional priorities rather than rigid
disease targets.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Chapter: The Practice of Medicine.

,2. When counseling a middle-aged smoker about
cardiovascular risk reduction under “Promoting Good
Health,” which brief intervention is most likely to increase
quit attempts?
A. Prescribing nicotine replacement without counseling
B. Advising cessation only if patient asks for help
C. Using the “Ask, Advise, Assess, Assist, Arrange” (5A)
framework
D. Telling them that quitting will not improve health
Correct: C
Rationale: The 5A model provides a structured, evidence-
based approach to promote behavior change and linkage
to treatment.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Chapter: Promoting Good Health.
3. A parent expresses concern about vaccine safety at a
pediatric visit. Which initial clinician communication
strategy is recommended to address “Vaccine Opposition
and Hesitancy”?
A. Dismiss concerns and insist on vaccination immediately
B. Use a presumptive recommendation and then address
questions
C. Delay any recommendation until the parent does more
online research
D. Provide only technical data about immunology
Correct: B
Rationale: A presumptive recommendation (e.g., “Today

, we’ll give the MMR and DTaP”) combined with empathic
addressing of concerns improves uptake.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Chapter: Vaccine Opposition and Hesitancy.
4. A clinician must choose whether to order a test whose
result will not change management. According to
“Decision-Making in Clinical Medicine,” what is the most
appropriate decision rule?
A. Order the test to be thorough regardless of
consequence
B. Only order tests expected to change pretest probability
sufficiently to alter management
C. Order all available tests for diagnostic certainty
D. Avoid tests when the patient is anxious
Correct: B
Rationale: High-value decision-making prioritizes tests that
are likely to change management or outcomes, minimizing
harm and resource use.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Chapter: Decision-Making in Clinical Medicine.
5. Before initiating azathioprine for an autoimmune condition
(topic: “Precision Medicine and Clinical Care”), which
pharmacogenomic test is most relevant to reduce risk of
severe myelosuppression?
A. HLA-B*57:01
B. TPMT activity or genotype