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Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The Practice of Medicine
Q1. Which principle best defines evidence-based clinical
decision-making in modern medical practice?
A. Reliance on expert opinion
B. Use of pathophysiologic reasoning alone
C. Integration of best evidence, clinical expertise, and patient
values
D. Adherence to standardized protocols only
Correct Answer: C
Rationale: Harrison emphasizes that evidence-based medicine
integrates scientific evidence with clinician expertise and
patient preferences to guide care.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
The Practice of Medicine

,2. Promoting Good Health
Q2. Which nursing intervention most directly supports
population-level health promotion?
A. Acute symptom management
B. Individualized pharmacologic therapy
C. Lifestyle risk-factor modification
D. Tertiary rehabilitation services
Correct Answer: C
Rationale: Health promotion focuses on modifying behavioral
and environmental risk factors to prevent disease.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Promoting Good Health


3. Vaccine Opposition and Hesitancy
Q3. A patient expresses fear of vaccine-related harm. What is
the most appropriate nursing response?
A. Provide corrective education using empathy
B. Emphasize legal requirements
C. Dismiss concerns as misinformation
D. Avoid discussion to preserve rapport
Correct Answer: A
Rationale: Harrison highlights respectful communication and
trust-building as key to addressing vaccine hesitancy.

, Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Vaccine Opposition and Hesitancy


4. Decision-Making in Clinical Medicine
Q4. Shared decision-making is most appropriate when:
A. Evidence strongly favors one option
B. Patient lacks decisional capacity
C. Multiple reasonable options exist
D. Emergency intervention is required
Correct Answer: C
Rationale: Shared decision-making is emphasized when trade-
offs exist between options and patient values influence
outcomes.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Decision-Making in Clinical Medicine


5. Precision Medicine and Clinical Care
Q5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Standardize care across populations
C. Tailor care based on individual variability
D. Eliminate environmental health factors
Correct Answer: C
Rationale: Precision medicine integrates genetic,