Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
1. The Practice of Medicine
1. Which principle best defines evidence-based clinical
practice?
A. Reliance on expert opinion
B. Application of randomized trials alone
C. Integration of best evidence, clinical expertise, and patient
values
D. Use of population data over individual care
Correct Answer: C
Rationale: Evidence-based medicine integrates scientific
evidence, clinician expertise, and patient preferences to guide
care.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
2. Promoting Good Health
,2. Which intervention has the greatest impact on reducing
premature mortality at the population level?
A. Early disease screening
B. Smoking cessation
C. Advanced pharmacotherapy
D. Genetic testing
Correct Answer: B
Rationale: Tobacco cessation is the single most effective health
promotion strategy to reduce morbidity and mortality.
Citation: Harrison’s, 22nd ed., Ch. 2
3. Vaccine Opposition and Hesitancy
3. Which nursing approach is most effective when addressing
vaccine hesitancy?
A. Presenting statistical risk data only
B. Dismissing patient concerns
C. Respectful dialogue addressing specific fears
D. Mandating vaccination without discussion
Correct Answer: C
Rationale: Trust-building and tailored communication improve
vaccine acceptance.
Citation: Harrison’s, 22nd ed., Ch. 3
4. Decision-Making in Clinical Medicine
, 4. Which factor most contributes to diagnostic error?
A. Excessive testing
B. Cognitive bias
C. Patient nonadherence
D. Lack of technology
Correct Answer: B
Rationale: Cognitive biases (anchoring, premature closure) are
major contributors to diagnostic error.
Citation: Harrison’s, 22nd ed., Ch. 4
5. Precision Medicine and Clinical Care
5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Standardize treatment protocols
C. Tailor therapy based on individual variability
D. Reduce health care costs exclusively
Correct Answer: C
Rationale: Precision medicine individualizes care using genetic,
environmental, and lifestyle factors.
Citation: Harrison’s, 22nd ed., Ch. 5
6. Screening and Prevention of Disease
6. Which screening principle is essential before
implementation?
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
1. The Practice of Medicine
1. Which principle best defines evidence-based clinical
practice?
A. Reliance on expert opinion
B. Application of randomized trials alone
C. Integration of best evidence, clinical expertise, and patient
values
D. Use of population data over individual care
Correct Answer: C
Rationale: Evidence-based medicine integrates scientific
evidence, clinician expertise, and patient preferences to guide
care.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
2. Promoting Good Health
,2. Which intervention has the greatest impact on reducing
premature mortality at the population level?
A. Early disease screening
B. Smoking cessation
C. Advanced pharmacotherapy
D. Genetic testing
Correct Answer: B
Rationale: Tobacco cessation is the single most effective health
promotion strategy to reduce morbidity and mortality.
Citation: Harrison’s, 22nd ed., Ch. 2
3. Vaccine Opposition and Hesitancy
3. Which nursing approach is most effective when addressing
vaccine hesitancy?
A. Presenting statistical risk data only
B. Dismissing patient concerns
C. Respectful dialogue addressing specific fears
D. Mandating vaccination without discussion
Correct Answer: C
Rationale: Trust-building and tailored communication improve
vaccine acceptance.
Citation: Harrison’s, 22nd ed., Ch. 3
4. Decision-Making in Clinical Medicine
, 4. Which factor most contributes to diagnostic error?
A. Excessive testing
B. Cognitive bias
C. Patient nonadherence
D. Lack of technology
Correct Answer: B
Rationale: Cognitive biases (anchoring, premature closure) are
major contributors to diagnostic error.
Citation: Harrison’s, 22nd ed., Ch. 4
5. Precision Medicine and Clinical Care
5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Standardize treatment protocols
C. Tailor therapy based on individual variability
D. Reduce health care costs exclusively
Correct Answer: C
Rationale: Precision medicine individualizes care using genetic,
environmental, and lifestyle factors.
Citation: Harrison’s, 22nd ed., Ch. 5
6. Screening and Prevention of Disease
6. Which screening principle is essential before
implementation?
