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Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. Which principle best defines the modern “practice of
medicine” as described in Harrison’s?
A. Application of standardized protocols only
B. Integration of scientific evidence with clinical judgment and
patient values
C. Reliance on diagnostic technology over clinical assessment
D. Focus on curative rather than preventive care
Correct Answer: B
Rationale: Harrison’s emphasizes that medicine is both a
science and an art, requiring integration of evidence-based
knowledge, clinician expertise, and patient preferences.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1


2. Which factor most strongly influences population health
outcomes?

,A. Access to tertiary medical centers
B. Genetic predisposition
C. Social and environmental determinants
D. Use of advanced diagnostics
Correct Answer: C
Rationale: Social determinants such as education, income,
housing, and environment exert a greater impact on health
outcomes than direct medical care alone.
Citation: Harrison’s, 22nd ed., Ch. 2


3. Vaccine hesitancy is most commonly driven by which
concern?
A. Cost of immunizations
B. Distrust in medical institutions and misinformation
C. Lack of vaccine availability
D. Religious prohibition
Correct Answer: B
Rationale: Harrison’s identifies misinformation, distrust, and
perceived risks as dominant contributors to vaccine hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3


4. Shared decision-making is MOST appropriate when:
A. Evidence strongly favors one option
B. The condition is life-threatening

, C. Multiple reasonable management options exist
D. The clinician has greater expertise than the patient
Correct Answer: C
Rationale: Shared decision-making is essential when benefits
and risks are closely balanced and patient values should guide
the choice.
Citation: Harrison’s, 22nd ed., Ch. 4


5. Precision medicine primarily seeks to:
A. Replace population-based guidelines
B. Tailor care based on individual variability
C. Reduce clinician judgment
D. Focus exclusively on genetic testing
Correct Answer: B
Rationale: Precision medicine integrates genetic,
environmental, and lifestyle factors to individualize care, not
replace clinical judgment.
Citation: Harrison’s, 22nd ed., Ch. 5


6. An essential nursing implication of precision medicine is:
A. Avoiding standardized care plans
B. Interpreting genomic data independently
C. Educating patients about personalized risk and treatment
D. Eliminating preventive screening