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What is immunotherapy - 🧠ANSWER ✔✔Sub type of biological therapy
(uses substances made from living organisms - naturally or in lab)
Some forms also considered type of antibiotic therapy (mABs) (targeted
therapy)
How does immunotherapy work? - 🧠ANSWER ✔✔Leverages your immune
system to fight cancer. It either stimulates or suppresses your immune
system to fight cancer, infections, or other diseases.
, Specifically in cancer, it attacks specific cancer cells, reduces or eliminates
side effects caused by cancer treatments (chemotherapy), and it works to
inhibit tumor cell growth by working with immune cells against tumor cells
Describe how the T cell tolerance "drives" an immune response -
🧠ANSWER ✔✔1) put key in ignition - signal one = TCR antigen MHC
(binding of T cell receptor)
2) step on gas pedal - signal 2 = CD28 (activates T cell stimulation)
3) step on brake - blockade of signal 2 (CTLA4 —> B7, PD-1 —> L1) (
inhibits T cell)
Key steps for an effective anti tumor T cell response - 🧠ANSWER ✔✔1 -
release of cancer cell antigens (cancer cell death)
2 - cancer antigen presentation on dendritic cells
3 - priming and activation
4 - trafficking of T cells into tumors
5 - infiltration of T cells into tumors
6 - recognition of cancer cells by T cells
7 - killing of cancer cells