1
NURS 5357 NEUROBIOLOGY EXAM 1 - UPDATED
SUMMER 25 LATEST QUESTIONS WITH ANSWERS
(100% CORRECT ANSWERS)
What are the three major hypotheses of psychosis and their neurotransmitter networks?
Answer: Dopamine theory - hyperactive dopamine at D2 receptors in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
Briefly explain the dopamine hypothesis of the positive and negative symptoms of
schizophrenia. Answer: The dopamine hypothesis of schizophrenia consists of:
There is too much dopamine activity in the mesolimbic dopamine pathway, which leads to
positive symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine pathway, which leads
to negative symptoms (such as blunting of affect, poverty of speech, anhedonia, and so on).
What pathway is responsible for regulating dopamine in the hypothalamus and affects the
release of prolactin? Answer: Tuberoinfundibular pathway
Drug-induced Parkinson's is caused by a decrease of dopamine in what pathway? Answer:
Nigrostriatal pathway
Brodmann's areas are differentiated by the: Answer: Cellular architecture
All of the following are true about the hippocampus except that it: Answer: Is disrupted by
frontal lobotomy
Which of the following statements is true about the cerebellum: Answer: Has been implicated
in autism.
Cytokines are involved with all of the following except: Answer: identifying T. pallidum
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, 2
Which of the following is a possible explanation for schizophrenia: Answer: Excessive pruning
Possible explanations for the role of thyroid hormone in mood disorders include all of the
following except: Answer: Changes in GR's
All of the following are plausible theories on the etiology of schizophrenia except? Answer:
Dopamine hypothesis
Auditory hallucinations have been shown to activate which region on fMRI? Answer: Superior
temporal lobe
All of the following suggest white matter impairment in schizophrenia except? Answer:
Significantly reduced white matter volume
Evidence that GABA interneurons are impaired in schizophrenia Answer: Reduced GAD67
All of the following support the reduced neuropil hypothesis except? Answer: oligodendrocyte
dysfunction
Evidence that schizophrenia is a biological disorder includes all of the following except?
Answer: Gliosis in the prefrontal cortex
Neurodevelopmental causes that could explain schizophrenia include excessive amounts of all
of the following except: Answer: Myelination
The NP's discuss a patient diagnosed with schizophrenia. The PMHNP knows that which of
the following groups of symptoms is most likely to be categorized as "negative symptoms" of
schizophrenia? Answer: Blunted affect, poor rapport, lack of spontaneity
There is a genetic contribution to some, perhaps all, forms of schizophrenia. In the case of
monozygotic twins who have identical genetic makeup, there is an approximately 50 percent
chance for them to develop schizophrenia. Answer: True
Princess, a 22-year-old female, presents with schizophrenia characterized by the presence of
positive, negative, cognitive, and affective symptoms. Which symptom dimension of
schizophrenia is most effectively treated with antipsychotics? Answer: Positive symptoms
© 2025 All rights reserved
NURS 5357 NEUROBIOLOGY EXAM 1 - UPDATED
SUMMER 25 LATEST QUESTIONS WITH ANSWERS
(100% CORRECT ANSWERS)
What are the three major hypotheses of psychosis and their neurotransmitter networks?
Answer: Dopamine theory - hyperactive dopamine at D2 receptors in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
Briefly explain the dopamine hypothesis of the positive and negative symptoms of
schizophrenia. Answer: The dopamine hypothesis of schizophrenia consists of:
There is too much dopamine activity in the mesolimbic dopamine pathway, which leads to
positive symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine pathway, which leads
to negative symptoms (such as blunting of affect, poverty of speech, anhedonia, and so on).
What pathway is responsible for regulating dopamine in the hypothalamus and affects the
release of prolactin? Answer: Tuberoinfundibular pathway
Drug-induced Parkinson's is caused by a decrease of dopamine in what pathway? Answer:
Nigrostriatal pathway
Brodmann's areas are differentiated by the: Answer: Cellular architecture
All of the following are true about the hippocampus except that it: Answer: Is disrupted by
frontal lobotomy
Which of the following statements is true about the cerebellum: Answer: Has been implicated
in autism.
Cytokines are involved with all of the following except: Answer: identifying T. pallidum
© 2025 All rights reserved
, 2
Which of the following is a possible explanation for schizophrenia: Answer: Excessive pruning
Possible explanations for the role of thyroid hormone in mood disorders include all of the
following except: Answer: Changes in GR's
All of the following are plausible theories on the etiology of schizophrenia except? Answer:
Dopamine hypothesis
Auditory hallucinations have been shown to activate which region on fMRI? Answer: Superior
temporal lobe
All of the following suggest white matter impairment in schizophrenia except? Answer:
Significantly reduced white matter volume
Evidence that GABA interneurons are impaired in schizophrenia Answer: Reduced GAD67
All of the following support the reduced neuropil hypothesis except? Answer: oligodendrocyte
dysfunction
Evidence that schizophrenia is a biological disorder includes all of the following except?
Answer: Gliosis in the prefrontal cortex
Neurodevelopmental causes that could explain schizophrenia include excessive amounts of all
of the following except: Answer: Myelination
The NP's discuss a patient diagnosed with schizophrenia. The PMHNP knows that which of
the following groups of symptoms is most likely to be categorized as "negative symptoms" of
schizophrenia? Answer: Blunted affect, poor rapport, lack of spontaneity
There is a genetic contribution to some, perhaps all, forms of schizophrenia. In the case of
monozygotic twins who have identical genetic makeup, there is an approximately 50 percent
chance for them to develop schizophrenia. Answer: True
Princess, a 22-year-old female, presents with schizophrenia characterized by the presence of
positive, negative, cognitive, and affective symptoms. Which symptom dimension of
schizophrenia is most effectively treated with antipsychotics? Answer: Positive symptoms
© 2025 All rights reserved
