ASCP Hematology Review questions and
answers 2026\2027 A+ Grade
Name the locations of active marrow in adults:
- correct answer sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
- correct answer yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation?
- correct answer spleen
When does the bone marrow take over hematopoiesis?
- correct answer after birth
What are the stages in order of the erythrocyte lineage?
- correct answer (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte,
(6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage?
- correct answer (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band,
(6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage?
- correct answer (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage?
- correct answer (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet
What are the stages in order of the lymphocyte lineage?
- correct answer (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
,Which growth factors stimulate the erythrocyte lineage?
- correct answer GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages?
- correct answer GM-CSF, IL-3
Which growth factors stimulate the platelet lineage?
- correct answer GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage?
- correct answer IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe?
- correct answer transferrin
What is the major storage form of Fe?
- correct answer ferritin
What is the long-term (H20) insoluble Fe storage form called?
- correct answer hemosiderin
Excess Iron is stored where? What does this cause?
- correct answer tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to?
- correct answer excessive formation of porphrins due to blockages in any enzymatic step in the heme
synthesis pathway.
Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors?
- correct answer porphyria
, Neuropsychiatirc symptoms are seen when a build up of which precursors occurs?
- correct answer early precursors (Delta-aminolevulinic acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs?
- correct answer later precursors (uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components?
- correct answer iron, protoporphyrin
What are the heme precursors in order of synthesis?
- correct answer (1)delta-aminolevulinic acid, (2)porphobilinogen, (3)uroporphyrinogen,
(4)coproporphyrinogen, (5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns?
- correct answer Hgb F
What type of hemoglobin is seen primarily in adults?
- correct answer Hgb A2
What type of hemoglobin is rarely seen in adults as well as newborns?
- correct answer Hgb A
What hemoglobin types are seen in embryos but not in adults or newborns?
- correct answer gower I, gower II, portland
All non-embryonic hemoglobin types are comprised of what type of globin chain?
- correct answer alpha
Hemoglobin A2 is composed of what types of globin chains?
- correct answer alpha, beta
answers 2026\2027 A+ Grade
Name the locations of active marrow in adults:
- correct answer sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
- correct answer yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation?
- correct answer spleen
When does the bone marrow take over hematopoiesis?
- correct answer after birth
What are the stages in order of the erythrocyte lineage?
- correct answer (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte,
(6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage?
- correct answer (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band,
(6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage?
- correct answer (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage?
- correct answer (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet
What are the stages in order of the lymphocyte lineage?
- correct answer (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
,Which growth factors stimulate the erythrocyte lineage?
- correct answer GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages?
- correct answer GM-CSF, IL-3
Which growth factors stimulate the platelet lineage?
- correct answer GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage?
- correct answer IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe?
- correct answer transferrin
What is the major storage form of Fe?
- correct answer ferritin
What is the long-term (H20) insoluble Fe storage form called?
- correct answer hemosiderin
Excess Iron is stored where? What does this cause?
- correct answer tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to?
- correct answer excessive formation of porphrins due to blockages in any enzymatic step in the heme
synthesis pathway.
Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors?
- correct answer porphyria
, Neuropsychiatirc symptoms are seen when a build up of which precursors occurs?
- correct answer early precursors (Delta-aminolevulinic acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs?
- correct answer later precursors (uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components?
- correct answer iron, protoporphyrin
What are the heme precursors in order of synthesis?
- correct answer (1)delta-aminolevulinic acid, (2)porphobilinogen, (3)uroporphyrinogen,
(4)coproporphyrinogen, (5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns?
- correct answer Hgb F
What type of hemoglobin is seen primarily in adults?
- correct answer Hgb A2
What type of hemoglobin is rarely seen in adults as well as newborns?
- correct answer Hgb A
What hemoglobin types are seen in embryos but not in adults or newborns?
- correct answer gower I, gower II, portland
All non-embryonic hemoglobin types are comprised of what type of globin chain?
- correct answer alpha
Hemoglobin A2 is composed of what types of globin chains?
- correct answer alpha, beta
