HESI 315 Review (2025/2026) UPDATE|EXAM QUESTIONS WITH MULTIPLE CHOICES |VERIFIED & REVISED ANSWERS (NEW)!!!

HESI 315 Review (2025/2026)
UPDATE|EXAM
QUESTIONS WITH MULTIPLE
CHOICES |VERIFIED & REVISED
ANSWERS (NEW)!!!
OverviewmofmHistamine2mBlockers:

TheremaremcurrentlymfourmH2RAsmavailable:mcimetidine,mranitidine,mfamotidine,mandmnizatidine

Questionm1mofm4

WhichminstructionsmwouldmthemnursemprovidemMr.mEvansmaboutmwhenmtomtakemthemprescribedmra
nitidine?

A.mTakemitmatmbedtimemormwithmmeals.

B.mTakemitmatmbedtime,mormaftermeveningmmeal.

C.mTakemitmaftermwakingmormjustmbeforemmeals.

D.mTakemitmaftermwakingmormwithmmeals.m-
mCORRECTmANSWERSmB.mTakemitmatmbedtime,mormaftermeveningmmeal.



Histamine2mblockersmshouldmbemtakenmatmbedtimemormaftermeveningmmeal.



Questionm2mofm4

Beforemadministeringmcimetidinemtomam27-year-
oldmfemalempatient,mwhichmpatientmparametersmwouldmamnursemensuremhavembeenmassessed?

A.Hepaticmfunction

B.mRenalmfunction

C.mThyroidmfunction

D.mPregnancymstatus

E.mFluidmandmelectrolytemstatusm-mCORRECTmANSWERSmA.Hepaticmfunction

,B.mRenalmfunction



D.mPregnancymstatus

E.mFluidmandmelectrolytemstatus



Questionm3mofm4

Whichmrespiratorymcomplicationmassociatedmwithmcimetidinemismamconcern,masmthemdrugmincrease
smgastricmpH?

A.mPneumonia

B.mAsthmamattack

C.mInterstitialmlungmdisease

D.mExacerbationmofmchronicmobstructivempulmonarymdiseasem(COPD)m-
mCORRECTmANSWERSmA.mPneumonia



Pneumoniamismamconcernminmpatientsmreceivingmcimetidine.mAsmthemdrugmincreasesmgastricmpH,mth
emriskmformpneumoniamalsomincreases.



Questionm4mofm4

Whichmeffectmwouldmamnursemanticipatemmaymoccurmifmampatientmtakingmphenytoinmismgivenmcimeti
dine?

A.mIncreasedmeffectmofmcimetidine

B.mDecreasedmeffectmofmcimetidine

C.mIncreasedmeffectmofmphenytoin

D.mDecreasedmeffectmofmphenytoinm-mCORRECTmANSWERSmC.mIncreasedmeffectmofmphenytoin

Whenmtakenmtogether,mcimetidinemincreasesmthemconcentrationmofmphenytoin,mthusmincreasingmit
smeffect.mThempatientmshouldmbemmonitoredmcloselymtomdeterminemwhethermamdosagemreductionmi
nmphenytoinmismwarranted.



Questionm1mofm8

, Withmwhichmmedicalmconditionmwouldmamnursemexpectmthemhealthmcaremprovidermtomreducemthem
dosagemofmranitidinemduemtompotentialmaccumulationmofmthemdrug?

Kidneymdisease

Crohnmdisease

Hepaticmimpairment

Cardiovascularmdiseasem-mCORRECTmANSWERSmKidneymdisease

Accumulationmofmranitidinemmaymoccurmwithmrenalmimpairment,mandmamdosagemreductionmismneed
edminmthesempatients.



Questionm2mofm8

Whichmoutcomemismanticipatedmasmamresultmofmhistamine2mreceptormblockersmobstructingmhistami
ne2mreceptorsminmthemparietalmcellsminmthemstomach?

Increaseminmhydrogenmionsmandmgastricmacid

Decreaseminmhydrogenmionsmandmgastricmacid

Increaseminmhydrogenmionsmandmdecreaseminmgastricmacid

Decreaseminmhydrogenmionsmandmincreaseminmgastricmacidm-
mCORRECTmANSWERSmDecreaseminmhydrogenmionsmandmgastricmacid



Themconcentrationmofmbothmhydrogenmionsmandmgastricmacidmismdecreasedmwhenmthemhistamine2m
receptorsmaremobstructedmbymhistamine2mreceptormblockers.



Questionm3mofm8

Whichmcomparisonmbetweenmcimetidinemandmranitidinemismaccurate?

Ranitidinemismmorempotentmthanmcimetidine.

Foodmslowsmthemabsorptionmofmranitidinembutmnotmcimetidine.

Ranitidine,mbutmnotmcimetidine,mismwellmabsorbedmfollowingmoralmadministration.

Foodmreducesmthemoverallmeffectsmofmranitidine.m-
mCORRECTmANSWERSmRanitidinemismmorempotentmthanmcimetidine.



Ranitidinemism5mtom12mtimesmmorempotentmthanmcimetidinembutmismlessmpotentmthanmfamotidine.