PHAR 100 EXAM QUESTIONS AND 100%
CORRECT ANSWERS
Phase One Drug Trial- ANSWER Small number of people
Absorption, distribution, elimination and adverse effects are monitored
Phase Two Drug Trial- ANSWER Small number of people
Determines whether drug is effective in the treatment
Phase Three Drug Trial- ANSWER Large number of people
Safety of the drug is carefully studied
Potency- ANSWER Amount of the drug that must be given to obtain a response
Efficacy- ANSWER Maximum effect of the drug
Paul Ehrlich - ANSWER Organoarsenic compounds
Salvarsan: syphilis treatment
Gerhard Domagk - ANSWER Sulfonamides
Prontosil: streptococcus
Antimetabolites - ANSWER Act against substances required for metabolism of an
organism
Example: sulfanilamide
, Sulfanilamide - ANSWER Antimetabolite
Therapeutic Index - ANSWER Lethal Dose (Toxicity) ÷ Effective Dose
Higher means safer
Parenteral Routes - ANSWER Intramuscular
Subcutaneous
Intravenous
Enteral Routes - ANSWER Mouth
Rectal
Under Tongue
Drug Dependence - ANSWER Physical dependence
Psychological dependence
Tolerance
Abuse Potential - ANSWER Dependence liability
Availability of drug
Harmfulness
CNS Depressants - ANSWER Alcohol
Barbiturates
Benzodiazepines
Sedative-Hypnotics - ANSWER Barbiturates
CORRECT ANSWERS
Phase One Drug Trial- ANSWER Small number of people
Absorption, distribution, elimination and adverse effects are monitored
Phase Two Drug Trial- ANSWER Small number of people
Determines whether drug is effective in the treatment
Phase Three Drug Trial- ANSWER Large number of people
Safety of the drug is carefully studied
Potency- ANSWER Amount of the drug that must be given to obtain a response
Efficacy- ANSWER Maximum effect of the drug
Paul Ehrlich - ANSWER Organoarsenic compounds
Salvarsan: syphilis treatment
Gerhard Domagk - ANSWER Sulfonamides
Prontosil: streptococcus
Antimetabolites - ANSWER Act against substances required for metabolism of an
organism
Example: sulfanilamide
, Sulfanilamide - ANSWER Antimetabolite
Therapeutic Index - ANSWER Lethal Dose (Toxicity) ÷ Effective Dose
Higher means safer
Parenteral Routes - ANSWER Intramuscular
Subcutaneous
Intravenous
Enteral Routes - ANSWER Mouth
Rectal
Under Tongue
Drug Dependence - ANSWER Physical dependence
Psychological dependence
Tolerance
Abuse Potential - ANSWER Dependence liability
Availability of drug
Harmfulness
CNS Depressants - ANSWER Alcohol
Barbiturates
Benzodiazepines
Sedative-Hypnotics - ANSWER Barbiturates
