Nurse Practitioner National NP Certification Exam Test Bank Verified Questions Answers 2025/ 2026

2026/2027: NURSE PRACTITIONER
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NURSE PRACTITIONER – NATIONAL NP CERTIFICATION
EXAM QUESTIONS AND CORRECT ANSWERS (VERIFIED
ANSWERS) PLUS RATIONALES 2025|2026 Q&A |
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1. A 68-year-old man with a 40-pack-year smoking history presents with
hematuria but no dysuria or flank pain. Which is the most likely diagnosis?
• A. UTI
• B. Bladder cancer
• C. Kidney stone
• D. BPH
Answer: B. Bladder cancer
Rationale: Painless hematuria in an older smoker is a red flag for bladder
cancer.


2. A patient with type 2 diabetes presents with numbness and tingling in both
feet. Which test is best for evaluation?
• A. Babinski reflex
• B. Monofilament test
• C. Romberg test
• D. Ankle-brachial index
Answer: B. Monofilament test
Rationale: Monofilament testing screens for peripheral neuropathy in
diabetic patients.


Management & Treatment
3. A 25-year-old woman with uncomplicated cystitis. Best initial therapy is:




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• A. Ciprofloxacin for 10 days
• B. Nitrofurantoin for 5 days
• C. TMP-SMX for 14 days
• D. Amoxicillin for 7 days
Answer: B. Nitrofurantoin for 5 days
Rationale: First-line for uncomplicated UTI is nitrofurantoin (5 days) or TMP-
SMX (3 days). Fluoroquinolones are reserved for resistant cases.


4. Which antihypertensive is contraindicated in pregnancy?
• A. Methyldopa
• B. Labetalol
• C. ACE inhibitors
• D. Nifedipine
Answer: C. ACE inhibitors
Rationale: ACE inhibitors are teratogenic and contraindicated in pregnancy.


Health Promotion & Disease Prevention
5. A 55-year-old woman with no risk factors. According to USPSTF, when
should colorectal cancer screening begin?
• A. Age 40
• B. Age 45
• C. Age 50
• D. Age 60
Answer: B. Age 45
Rationale: USPSTF (2021) recommends colorectal cancer screening starting
at 45 for average-risk adults.




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6. Which vaccine is recommended for all adults ≥50 years regardless of past
infection?
• A. Zoster vaccine
• B. Hepatitis B vaccine
• C. Pneumococcal vaccine
• D. Influenza vaccine
Answer: A. Zoster vaccine
Rationale: Shingrix (zoster) is recommended for adults ≥50 regardless of
prior varicella infection.


Professional Role (ANCC focus)
7. A nurse practitioner lobbies for expanded prescriptive authority in her
state. This is an example of:
• A. Case management
• B. Policy advocacy
• C. Health promotion
• D. Clinical decision-making
Answer: B. Policy advocacy
Rationale: Involvement in legislative or regulatory processes represents
policy advocacy.


8. Which ethical principle refers to the NP’s obligation to do no harm?
• A. Autonomy
• B. Justice
• C. Nonmaleficence
• D. Beneficence
Answer: C. Nonmaleficence




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and solutions

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NP solutions
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Rationale: Nonmaleficence = “do no harm”; beneficence = act in best
interest of patient.


Advanced Clinical Knowledge
9. A child presents with a barking cough, stridor, and hoarseness. What is the
likely diagnosis?
• A. Epiglottitis
• B. Croup
• C. Bronchiolitis
• D. Asthma
Answer: B. Croup
Rationale: Classic presentation of viral croup = barking cough + inspiratory
stridor.


10.Which lab finding is consistent with iron-deficiency anemia?
• A. High ferritin, high MCV
• B. Low ferritin, low MCV
• C. High ferritin, low MCV
• D. Normal ferritin, high MCV
Answer: B. Low ferritin, low MCV
Rationale: Iron-deficiency anemia = microcytic, hypochromic anemia with
low ferritin.


That’s a starter set of 10 NP exam-style practice questions with bold answers
and italic rationales.
Would you like me to build this into a full 100-question NP practice exam (like I
did for NBCOT, NAVLE, and ARDMS), or break it into smaller 25-question sections
for easier study?



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EXAMFrequently
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