TEST BANK
YT
Cellular and Molecular Immunology
YT YT YT
Abul Abbas, Andrew Lichtman, and Shiv Pillai
YT YT YT YT YT YT
10th Edition
YT
@
Pa
ss
vi
be
s
@Passvibes @Passvibes
, Table of Contents
YT YT
ChapterYT01YTPropertiesYTandYTOverviewYTofYTImmuneYTResponses 1
ChapterYT02YTCellsYTandYTTissuesYTofYTtheYTImmuneYTSystem 3
ChapterYT03YTLeukocyteYTCirculationYTandYTMigrationYTIntoYTTissues 6
ChapterYT04YTInnateYTImmunity 10
ChapterYT05YTAntibodiesYTandYTAntigens 17
ChapterYT06YTAntigenYTPresentationYTtoYTTYTLymphocytesYTandYTtheYTFunctionsYTofYTMajor
HistocompatibilityYTComplexYT Molecules 20
ChapterYT07YTImmuneYTReceptorsYTandYTSignalYTTransduction 27
ChapterYT08YTLymphocyteYTDevelopmentYTandYTAntigenYTReceptorYTGeneYTRearrangement 30
ChapterYT09YTActivationYTofYTTYTLymphocytes 34
ChapterYT10YTDifferentiationYTandYTFunctionsYTofYTCD4+YTEffectorYTTYTCells 38
@
ChapterYT11YTDifferentiationYTandYTFunctionsYTofYTCD8+YTEffectorYTTYTCells 42
ChapterYT12YTBYTCellYTActivationYTandYTAntibodyYTProduction 46
ChapterYT13YTEffectorYTMechanismsYTofYTHumoralYTImmunity 52
ChapterYT14YTSpecializedYTImmunityYTatYTEpithelialYTBarriersYTandYTinYTImmuneYTPrivilegedYTTissues 56
Pa
ChapterYT15YTImmunologicYTToleranceYTandYTAutoimmunity 62
ChapterYT16YTImmunityYTtoYTMicrobes 67
ChapterYT17YTTransplantationYTImmunology 72
ChapterYT18YTTumorYTImmunology 77
ss
ChapterYT19YTHypersensitivityYTDisorders 81
ChapterYT20YTAllergy 86
ChapterYT21YTPrimaryYTandYTAcquiredYT Immunodeficiencies 89
vi
be
s
@Passvibes @Passvibes
, Chapter 01: Properties and Overview of Immune Responses
YT YT YT YT YT YT YT
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
YT YT YT YT YT YT YT YT YT
MULTIPLEYTCHOICE
1. TheYTprincipalYTfunctionYTofYTtheYTimmuneYTsystemYTis:
a. DefenseYTagainstYTcancer
b. RepairYTofYTinjuredYTtissues
c. DefenseYTagainstYTmicrobialYTinfections
d. PreventionYTofYTinflammatoryYTdiseases
e. ProtectionYTagainstYTenvironmentalYTtoxins
ANS:Y T C
TheYTimmuneYTsystemYThasYTevolvedYTinYTtheYTsettingYTofYTselectiveYTpressuresYTimposedYTbyYT
microbialYTinfections.YTAlthoughYTimmuneYTresponsesYTtoYTcancerYTmayYToccur,YTtheYTconcept
YTthatYT“immunosurveillance”YTagainstYTcancerYTisYTaYTprincipalYTfunctionYTofYTtheYTimmuneYTs
@
ystemYTisYTcontroversial.YTRepairYTofYTinjuredYTtissuesYTmayYTbeYTaYTsecondaryYTconsequenceYT
ofYTtheYTimmuneYTresponsesYTandYTinflammation.YTAlthoughYTtheYTimmuneYTsystemYThasYTregu
latoryYTfeaturesYTthatYTareYTneededYTtoYTpreventYTexcessiveYTinflammation,YTpreventionYTofYTinf
lammatoryYTdiseasesYTisYTnotYTaYTprimaryYTfunction.YTTheYTimmuneYTsystemYTcanYTprotectYTagai
nstYTmicrobialYTtoxins,YTbutYTitYTgenerallyYTdoesYTnotYTofferYTprotectionYTagainstYTtoxinsYTofYTno
Pa
nbiologicYTorigin.
2. WhichYTofYTtheYTfollowingYTinfectiousYTdiseasesYTwasYTpreventedYTbyYTtheYTfirstYTsu
ccessfulYTvaccination?
a. Polio
b. Tuberculosis
ss
c. Smallpox
d. Tetanus
e. Rubella
ANS:Y T C
vi
InYT1798,YTEdwardYTJennerYTreportedYTtheYTfirstYTintentionalYTsuccessfulYTvaccination,YTwhichY
TwasYTagainstYTsmallpoxYTinYTaYTboy,YTusingYTmaterialYTfromYTtheYTcowpoxYTpustulesYTofYTaYTmilk
maid.YTInYT1980,YTsmallpoxYTwasYTreportedYTtoYTbeYTeradicatedYTworldwideYTbyYTaYTvaccination
YTprogram.YTEffectiveYTvaccinesYTagainstYTtetanusYTtoxin,YTrubellaYTvirus,YTandYTpoliovirusYTwe
be
reYTdevelopedYTinYTtheYT20thYTcenturyYTandYTareYTwidelyYTused.YTThereYTisYTnoYTeffectiveYTvacci
neYTagainstYTMycobacteriumYTtuberculosis.
3. WhichYTofYTtheYTfollowingYTisYTaYTuniqueYTpropertyYTofYTtheYTadaptiveYTimmuneYTsystem?
a. HighlyYTdiverseYTrepertoireYTofYTspecificitiesYTforYTantigens
b. Self-nonselfYTdiscrimination
s
c. RecognitionYTofYTmicrobialYTstructuresYTbyYTbothYTcell-associatedYTandYTsolubleYTreceptors
d. ProtectionYTagainstYTviralYTinfections
e. ResponsesYTthatYThaveYTtheYTsameYTkineticsYTandYTmagnitudeYTonYTrepeatedYTexposur
eYTtoYTtheYTsameYTmicrobe
ANS:Y T A
@Passvibes @Passvibes
, HighlyYTdiverseYTrepertoiresYTofYTspecificitiesYTforYTantigensYTareYTfoundYTonlyYTinYTTYTandYTBYT
lymphocytes,YTwhichYTareYTtheYTcentralYTcellularYTcomponentsYTofYTtheYTadaptiveYTimmuneYTsy
stem.YTBothYTtheYTinnateYTandYTtheYTadaptiveYTimmuneYTsystemsYTuseYTcell-
associatedYTandYTsolubleYTreceptorsYTtoYTrecognizeYTmicrobes,YTdisplayYTsomeYTdegreeYTofYTself
-
nonselfYTdiscrimination,YTandYTprotectYTagainstYTviruses.YTOnYTrepeatedYTexposureYTtoYTtheYTsa
meYTmicrobe,YTtheYTadaptiveYTimmuneYTresponseYTbecomesYTmoreYTrapidYTandYTofYTgreaterYTma
gnitude;YTthisYTisYTtheYTmanifestationYTofYTmemory.
4. AntibodiesYTandYTTYTlymphocytesYTareYTtheYTrespectiveYTmediatorsYTofYTwhichYTtwoYTt
ypesYTofYTimmunity?
a. InnateYTandYTadaptive
b. PassiveYTandYTactive
c. SpecificYTandYTnonspecific
d. HumoralYTandYTcell-mediated
e. AdultYTandYTneonatal
@
ANS:Y T D
BothYTBYTandYTTYTlymphocytesYTareYTprincipalYTcomponentsYTofYTadaptiveYTimmunity.YTBYTlymp
hocytesYTproduceYTantibodies,YTwhichYTareYTtheYTrecognitionYTandYTeffectorYTmoleculesYTofYThu
moralYTimmuneYTresponsesYTtoYTextracellularYTpathogens.YTTYTcellsYTrecognizeYTandYTpromoteYT
eradicationYTofYTintracellularYTpathogensYTinYTcell-
Pa
mediatedYTimmunity.YTPassiveYTandYTactiveYTimmunityYTbothYTcanYTbeYTmediatedYTbyYTeitherYTBYT
orYTTYTlymphocytes.YTSpecificYTimmunityYTisYTanotherYTtermYTforYTadaptiveYTimmunity.YTBothYTB
YTandYTTYTlymphocytesYTparticipateYTinYTadultYTadaptiveYTimmunityYTbutYTareYTstillYTdevelopingYT
inYTtheYTneonatalYTperiod.
5. TheYTtwoYTmajorYTfunctionalYTclassesYTofYTeffectorYTTYTlymphocytesYTare:
ss
a. HelperYTTYTlymphocytesYTandYTcytotoxicYTTYTlymphocytes
b. NaturalYTkillerYTcellsYTandYTcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryYTTYTcellsYTandYTeffectorYTTYTcells
d. HelperYTcellsYTandYTantigen-presentingYTcells
vi
e. CytotoxicYTTYTlymphocytesYTandYTtargetYTcells
ANS:Y T A
TYTcellsYTcanYTbeYTclassifiedYTintoYTeffectorYTsubsetsYTthatYTperformYTdifferentYTeffectorYTfunctio
ns.YTMostYTeffectorYTTYTcellsYTareYTeitherYThelperYTTYTlymphocytes,YTwhichYTenhanceYTtheYTresp
be
onsesYTofYTotherYTimmuneYTcells,YTincludingYTphagocytesYTandYTBYTcells,YTtoYTinfections,YTorYTc
ytotoxicYTTYTlymphocytes,YTwhichYTdirectlyYTkillYTinfectedYTcells.YTNaturalYTkillerYTcellsYTareYT
notYTTYTlymphocytes.
Antigen-
presentingYTcellsYTusuallyYTareYTnotYTTYTcells.YTMemoryYTTYTcellsYTareYTnotYTeffectorYTTYTcells.
s
6. WhichYTofYTtheYTfollowingYTcellYTtypesYTisYTrequiredYTforYTallYTadaptiveYThumoralYTimmuneYTresponse
s?
a. NaturalYTkillerYTcells
b. DendriticYTcells
c. CytolyticYTTYTlymphocytes
d. BYTlymphocytes
e. HelperYTTYTlymphocytes
ANS:Y T D
HumoralYTimmuneYTresponsesYTareYTantibody-
mediatedYTimmuneYTresponses,YTandYTallYTantibodiesYTareYTmadeYTbyYTBYTlymphocytesYTandYT
@Passvibes @Passvibes
YT
Cellular and Molecular Immunology
YT YT YT
Abul Abbas, Andrew Lichtman, and Shiv Pillai
YT YT YT YT YT YT
10th Edition
YT
@
Pa
ss
vi
be
s
@Passvibes @Passvibes
, Table of Contents
YT YT
ChapterYT01YTPropertiesYTandYTOverviewYTofYTImmuneYTResponses 1
ChapterYT02YTCellsYTandYTTissuesYTofYTtheYTImmuneYTSystem 3
ChapterYT03YTLeukocyteYTCirculationYTandYTMigrationYTIntoYTTissues 6
ChapterYT04YTInnateYTImmunity 10
ChapterYT05YTAntibodiesYTandYTAntigens 17
ChapterYT06YTAntigenYTPresentationYTtoYTTYTLymphocytesYTandYTtheYTFunctionsYTofYTMajor
HistocompatibilityYTComplexYT Molecules 20
ChapterYT07YTImmuneYTReceptorsYTandYTSignalYTTransduction 27
ChapterYT08YTLymphocyteYTDevelopmentYTandYTAntigenYTReceptorYTGeneYTRearrangement 30
ChapterYT09YTActivationYTofYTTYTLymphocytes 34
ChapterYT10YTDifferentiationYTandYTFunctionsYTofYTCD4+YTEffectorYTTYTCells 38
@
ChapterYT11YTDifferentiationYTandYTFunctionsYTofYTCD8+YTEffectorYTTYTCells 42
ChapterYT12YTBYTCellYTActivationYTandYTAntibodyYTProduction 46
ChapterYT13YTEffectorYTMechanismsYTofYTHumoralYTImmunity 52
ChapterYT14YTSpecializedYTImmunityYTatYTEpithelialYTBarriersYTandYTinYTImmuneYTPrivilegedYTTissues 56
Pa
ChapterYT15YTImmunologicYTToleranceYTandYTAutoimmunity 62
ChapterYT16YTImmunityYTtoYTMicrobes 67
ChapterYT17YTTransplantationYTImmunology 72
ChapterYT18YTTumorYTImmunology 77
ss
ChapterYT19YTHypersensitivityYTDisorders 81
ChapterYT20YTAllergy 86
ChapterYT21YTPrimaryYTandYTAcquiredYT Immunodeficiencies 89
vi
be
s
@Passvibes @Passvibes
, Chapter 01: Properties and Overview of Immune Responses
YT YT YT YT YT YT YT
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
YT YT YT YT YT YT YT YT YT
MULTIPLEYTCHOICE
1. TheYTprincipalYTfunctionYTofYTtheYTimmuneYTsystemYTis:
a. DefenseYTagainstYTcancer
b. RepairYTofYTinjuredYTtissues
c. DefenseYTagainstYTmicrobialYTinfections
d. PreventionYTofYTinflammatoryYTdiseases
e. ProtectionYTagainstYTenvironmentalYTtoxins
ANS:Y T C
TheYTimmuneYTsystemYThasYTevolvedYTinYTtheYTsettingYTofYTselectiveYTpressuresYTimposedYTbyYT
microbialYTinfections.YTAlthoughYTimmuneYTresponsesYTtoYTcancerYTmayYToccur,YTtheYTconcept
YTthatYT“immunosurveillance”YTagainstYTcancerYTisYTaYTprincipalYTfunctionYTofYTtheYTimmuneYTs
@
ystemYTisYTcontroversial.YTRepairYTofYTinjuredYTtissuesYTmayYTbeYTaYTsecondaryYTconsequenceYT
ofYTtheYTimmuneYTresponsesYTandYTinflammation.YTAlthoughYTtheYTimmuneYTsystemYThasYTregu
latoryYTfeaturesYTthatYTareYTneededYTtoYTpreventYTexcessiveYTinflammation,YTpreventionYTofYTinf
lammatoryYTdiseasesYTisYTnotYTaYTprimaryYTfunction.YTTheYTimmuneYTsystemYTcanYTprotectYTagai
nstYTmicrobialYTtoxins,YTbutYTitYTgenerallyYTdoesYTnotYTofferYTprotectionYTagainstYTtoxinsYTofYTno
Pa
nbiologicYTorigin.
2. WhichYTofYTtheYTfollowingYTinfectiousYTdiseasesYTwasYTpreventedYTbyYTtheYTfirstYTsu
ccessfulYTvaccination?
a. Polio
b. Tuberculosis
ss
c. Smallpox
d. Tetanus
e. Rubella
ANS:Y T C
vi
InYT1798,YTEdwardYTJennerYTreportedYTtheYTfirstYTintentionalYTsuccessfulYTvaccination,YTwhichY
TwasYTagainstYTsmallpoxYTinYTaYTboy,YTusingYTmaterialYTfromYTtheYTcowpoxYTpustulesYTofYTaYTmilk
maid.YTInYT1980,YTsmallpoxYTwasYTreportedYTtoYTbeYTeradicatedYTworldwideYTbyYTaYTvaccination
YTprogram.YTEffectiveYTvaccinesYTagainstYTtetanusYTtoxin,YTrubellaYTvirus,YTandYTpoliovirusYTwe
be
reYTdevelopedYTinYTtheYT20thYTcenturyYTandYTareYTwidelyYTused.YTThereYTisYTnoYTeffectiveYTvacci
neYTagainstYTMycobacteriumYTtuberculosis.
3. WhichYTofYTtheYTfollowingYTisYTaYTuniqueYTpropertyYTofYTtheYTadaptiveYTimmuneYTsystem?
a. HighlyYTdiverseYTrepertoireYTofYTspecificitiesYTforYTantigens
b. Self-nonselfYTdiscrimination
s
c. RecognitionYTofYTmicrobialYTstructuresYTbyYTbothYTcell-associatedYTandYTsolubleYTreceptors
d. ProtectionYTagainstYTviralYTinfections
e. ResponsesYTthatYThaveYTtheYTsameYTkineticsYTandYTmagnitudeYTonYTrepeatedYTexposur
eYTtoYTtheYTsameYTmicrobe
ANS:Y T A
@Passvibes @Passvibes
, HighlyYTdiverseYTrepertoiresYTofYTspecificitiesYTforYTantigensYTareYTfoundYTonlyYTinYTTYTandYTBYT
lymphocytes,YTwhichYTareYTtheYTcentralYTcellularYTcomponentsYTofYTtheYTadaptiveYTimmuneYTsy
stem.YTBothYTtheYTinnateYTandYTtheYTadaptiveYTimmuneYTsystemsYTuseYTcell-
associatedYTandYTsolubleYTreceptorsYTtoYTrecognizeYTmicrobes,YTdisplayYTsomeYTdegreeYTofYTself
-
nonselfYTdiscrimination,YTandYTprotectYTagainstYTviruses.YTOnYTrepeatedYTexposureYTtoYTtheYTsa
meYTmicrobe,YTtheYTadaptiveYTimmuneYTresponseYTbecomesYTmoreYTrapidYTandYTofYTgreaterYTma
gnitude;YTthisYTisYTtheYTmanifestationYTofYTmemory.
4. AntibodiesYTandYTTYTlymphocytesYTareYTtheYTrespectiveYTmediatorsYTofYTwhichYTtwoYTt
ypesYTofYTimmunity?
a. InnateYTandYTadaptive
b. PassiveYTandYTactive
c. SpecificYTandYTnonspecific
d. HumoralYTandYTcell-mediated
e. AdultYTandYTneonatal
@
ANS:Y T D
BothYTBYTandYTTYTlymphocytesYTareYTprincipalYTcomponentsYTofYTadaptiveYTimmunity.YTBYTlymp
hocytesYTproduceYTantibodies,YTwhichYTareYTtheYTrecognitionYTandYTeffectorYTmoleculesYTofYThu
moralYTimmuneYTresponsesYTtoYTextracellularYTpathogens.YTTYTcellsYTrecognizeYTandYTpromoteYT
eradicationYTofYTintracellularYTpathogensYTinYTcell-
Pa
mediatedYTimmunity.YTPassiveYTandYTactiveYTimmunityYTbothYTcanYTbeYTmediatedYTbyYTeitherYTBYT
orYTTYTlymphocytes.YTSpecificYTimmunityYTisYTanotherYTtermYTforYTadaptiveYTimmunity.YTBothYTB
YTandYTTYTlymphocytesYTparticipateYTinYTadultYTadaptiveYTimmunityYTbutYTareYTstillYTdevelopingYT
inYTtheYTneonatalYTperiod.
5. TheYTtwoYTmajorYTfunctionalYTclassesYTofYTeffectorYTTYTlymphocytesYTare:
ss
a. HelperYTTYTlymphocytesYTandYTcytotoxicYTTYTlymphocytes
b. NaturalYTkillerYTcellsYTandYTcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryYTTYTcellsYTandYTeffectorYTTYTcells
d. HelperYTcellsYTandYTantigen-presentingYTcells
vi
e. CytotoxicYTTYTlymphocytesYTandYTtargetYTcells
ANS:Y T A
TYTcellsYTcanYTbeYTclassifiedYTintoYTeffectorYTsubsetsYTthatYTperformYTdifferentYTeffectorYTfunctio
ns.YTMostYTeffectorYTTYTcellsYTareYTeitherYThelperYTTYTlymphocytes,YTwhichYTenhanceYTtheYTresp
be
onsesYTofYTotherYTimmuneYTcells,YTincludingYTphagocytesYTandYTBYTcells,YTtoYTinfections,YTorYTc
ytotoxicYTTYTlymphocytes,YTwhichYTdirectlyYTkillYTinfectedYTcells.YTNaturalYTkillerYTcellsYTareYT
notYTTYTlymphocytes.
Antigen-
presentingYTcellsYTusuallyYTareYTnotYTTYTcells.YTMemoryYTTYTcellsYTareYTnotYTeffectorYTTYTcells.
s
6. WhichYTofYTtheYTfollowingYTcellYTtypesYTisYTrequiredYTforYTallYTadaptiveYThumoralYTimmuneYTresponse
s?
a. NaturalYTkillerYTcells
b. DendriticYTcells
c. CytolyticYTTYTlymphocytes
d. BYTlymphocytes
e. HelperYTTYTlymphocytes
ANS:Y T D
HumoralYTimmuneYTresponsesYTareYTantibody-
mediatedYTimmuneYTresponses,YTandYTallYTantibodiesYTareYTmadeYTbyYTBYTlymphocytesYTandYT
@Passvibes @Passvibes
