CSO Exam: Interactions with Cancer Medications
v v v v v
Questions with Correct Answers 2025/2026
v v v v v
Bortezomib-CORRECT ANSWER-(Velcade) v v v v
v IV or SQ
v v
-green tea should be avoided while taking this drug, especially in liquid and capsule forms
v v v v v v v v v v v v v v
-CYP3A4 inhibitors or inducers may alter drug activity, monitor closely
v v v v v v v v v
Capecitabine - CORRECT ANSWER -Xeloda v v v v
Oral directions: take within 30 mins of a mealw/full glass of water
v v v v v v v v v v v
-alteredcoagulation when takenwith Warfarin,monitor closely
v v v v v v v
-Vitamin B6 (50-100mg 2-3x/day) mayhelp to prevent/reduce the incidence and severity of
v v v v v v v v v v v v
foot/hand syndrome
v v
Cetuximab -CORRECT ANSWER -Erbitux IV v v v v v
-monitor serum mag and calcium levels closely
v v v v v v
-at risk populations: elderly, hypomagnesia at baseline, pts who have received prior tx w/oxaliplatin
v v v v v v v v v v v v v
Cisplatin-CORRECT ANSWER -Platinol IV
v v v v v
-rigorous hydration is necessary to prevent nephrotoxicity
v v v v v v
, -carefully monitor renal function (BUN and Cr) and serum electrolytes (Mg, Ca, Na, K) levels closely
v v v v v v v v v v v v v v v
-at risk populations: elderly, hypomag or those w/impaired renal function at baseline
v v v v v v v v v v v
cyclophosphamide-CORRECT ANSWER-Cytoxan v v v v
v IV or oral
v v
Oral: take preferably earlier inthe dayand w/vigorous hydration throughout the day
v v v v v v v v v v v v
-advise vigorous oralhydration (3L/day)
v v v v
-instruct pts to empty bladder every 2-3 hours during waking hours
v v v v v v v v v v
-Mesna is given with high-dose cyclophosphamide to prevent hemorrhagic cystitis
v v v v v v v v v
-increases the effect of anticoagulants, so dose may need to be decreased
v v v v v v v v v v v
Dasatinib-CORRECT ANSWER -Sprycel Oral: v v v v v
v take with or w/o food
v v v v
-avoid CYP3A4 inducers which may decrease drug activity (St. John's Wort, phenobarbital)
v v v v v v v v v v v
-avoid CYP3A4 inhibitorswhich may increase drug activity (grapefruit juice, ketoconazole,
v v v v v v v v v v
erythromycin)
v
-do not crush or cut drug
v v v v v
Busulfan - CORRECT ANSWER -Myleran v v v v
-aspirin containing OTC medications should be avoided while taking thisdrug
v v v v v v v v v v
Bexarotene - CORRECT ANSWER -Targretin v v v v
v v v v v
Questions with Correct Answers 2025/2026
v v v v v
Bortezomib-CORRECT ANSWER-(Velcade) v v v v
v IV or SQ
v v
-green tea should be avoided while taking this drug, especially in liquid and capsule forms
v v v v v v v v v v v v v v
-CYP3A4 inhibitors or inducers may alter drug activity, monitor closely
v v v v v v v v v
Capecitabine - CORRECT ANSWER -Xeloda v v v v
Oral directions: take within 30 mins of a mealw/full glass of water
v v v v v v v v v v v
-alteredcoagulation when takenwith Warfarin,monitor closely
v v v v v v v
-Vitamin B6 (50-100mg 2-3x/day) mayhelp to prevent/reduce the incidence and severity of
v v v v v v v v v v v v
foot/hand syndrome
v v
Cetuximab -CORRECT ANSWER -Erbitux IV v v v v v
-monitor serum mag and calcium levels closely
v v v v v v
-at risk populations: elderly, hypomagnesia at baseline, pts who have received prior tx w/oxaliplatin
v v v v v v v v v v v v v
Cisplatin-CORRECT ANSWER -Platinol IV
v v v v v
-rigorous hydration is necessary to prevent nephrotoxicity
v v v v v v
, -carefully monitor renal function (BUN and Cr) and serum electrolytes (Mg, Ca, Na, K) levels closely
v v v v v v v v v v v v v v v
-at risk populations: elderly, hypomag or those w/impaired renal function at baseline
v v v v v v v v v v v
cyclophosphamide-CORRECT ANSWER-Cytoxan v v v v
v IV or oral
v v
Oral: take preferably earlier inthe dayand w/vigorous hydration throughout the day
v v v v v v v v v v v v
-advise vigorous oralhydration (3L/day)
v v v v
-instruct pts to empty bladder every 2-3 hours during waking hours
v v v v v v v v v v
-Mesna is given with high-dose cyclophosphamide to prevent hemorrhagic cystitis
v v v v v v v v v
-increases the effect of anticoagulants, so dose may need to be decreased
v v v v v v v v v v v
Dasatinib-CORRECT ANSWER -Sprycel Oral: v v v v v
v take with or w/o food
v v v v
-avoid CYP3A4 inducers which may decrease drug activity (St. John's Wort, phenobarbital)
v v v v v v v v v v v
-avoid CYP3A4 inhibitorswhich may increase drug activity (grapefruit juice, ketoconazole,
v v v v v v v v v v
erythromycin)
v
-do not crush or cut drug
v v v v v
Busulfan - CORRECT ANSWER -Myleran v v v v
-aspirin containing OTC medications should be avoided while taking thisdrug
v v v v v v v v v v
Bexarotene - CORRECT ANSWER -Targretin v v v v
