ATI Fundamentals Proctored
Examination 2026: A Comprehensive
Academic Study Guide with Evidence-
Based Practice Questions
Which side effects are most commonly associated with Elavil (amitriptyline)?
A. Hypertension and insomnia
B. Weight loss and diarrhea
C. Orthostatic hypotension and dry mouth
D. Hyperreflexia and fever
Rationale: Elavil is a tricyclic antidepressant with anticholinergic effects, causing dry mouth and
orthostatic hypotension. The other options reflect effects not typical of TCAs.
Which drug class interacts dangerously with foods containing tyramine?
A. SSRIs
B. TCAs
C. MAOIs
D. Benzodiazepines
Rationale: MAOIs inhibit tyramine breakdown, leading to hypertensive crisis. Other
antidepressant classes do not have this interaction.
A common adverse effect of Prozac (fluoxetine) is:
A. Agranulocytosis
B. Sexual dysfunction
C. Gingival hyperplasia
D. Bradycardia
Rationale: SSRIs commonly cause sexual dysfunction. The other effects are associated with
different medication classes.
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Which findings indicate serotonin syndrome?
A. Hypotension and bradycardia
B. Muscle rigidity and hypothermia
C. Change in mental status, tremors, and hyperreflexia
D. Dry mouth and urinary retention
Rationale: Serotonin syndrome presents with neuromuscular hyperactivity and altered mental
status. Anticholinergic effects are unrelated.
Therapeutic lithium levels range from:
A. 0.1–0.3 mEq/L
B. 0.4–1.0 mEq/L
C. 1.5–2.5 mEq/L
D. 2.0–3.0 mEq/L
Rationale: Lithium levels above 1.5 mEq/L increase toxicity risk. Lower levels may be
ineffective.
Which medication interaction increases the risk of lithium toxicity?
A. Acetaminophen
B. Antacids
C. NSAIDs
D. Beta blockers
Rationale: NSAIDs reduce renal lithium clearance, raising serum levels. The other medications
do not significantly affect lithium.
Which teaching helps prevent lithium toxicity?
A. Increase caffeine intake
B. Follow a low-sodium diet
C. Avoid activities causing sodium or water depletion
D. Restrict fluid intake
Rationale: Sodium and fluid loss increase lithium levels. Adequate hydration is essential.
Which adverse effect is most commonly associated with lithium therapy?
A. Alopecia
B. Tremors
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C. Constipation
D. Photosensitivity
Rationale: Fine hand tremors are a common lithium side effect. The others are not typical.
A client taking Depakote requires monitoring of which labs?
A. INR, potassium, calcium
B. BUN, creatinine, glucose
C. Platelet count, amylase, liver function tests
D. Sodium, magnesium, phosphate
Rationale: Depakote can cause thrombocytopenia, pancreatitis, and hepatotoxicity.
Positive symptoms of schizophrenia are most closely related to:
A. Mood and affect
B. Social functioning
C. Behavior, thought, and speech
D. Memory and cognition
Rationale: Positive symptoms include hallucinations, delusions, and disorganized
speech/behavior.
Negative symptoms of schizophrenia include:
A. Delusions and hallucinations
B. Flight of ideas
C. Social withdrawal, lack of emotion, and lack of energy
D. Pressured speech
Rationale: Negative symptoms reflect absence of normal behaviors and emotions.
Thorazine (chlorpromazine) is most effective in improving which symptoms?
A. Cognitive symptoms
B. Negative symptoms
C. Positive symptoms
D. Mood symptoms
Rationale: First-generation antipsychotics primarily treat positive symptoms.
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Which intervention helps relieve anticholinergic effects from Prolixin?
A. Limit fluid intake
B. Avoid oral hygiene
C. Chew gum, sip liquids, or suck hard candy
D. Use antihistamines
Rationale: These measures stimulate saliva and relieve dry mouth caused by anticholinergic
effects.
Several hours after administering a typical antipsychotic, the nurse should monitor for:
A. Tardive dyskinesia
B. Neuroleptic malignant syndrome
C. Acute dystonia such as neck spasms
D. Agranulocytosis
Rationale: Acute dystonia occurs within hours to days of initiating typical antipsychotics.
Which lab must be closely monitored in a client taking Clozaril (clozapine)?
A. Platelet count
B. Liver enzymes
C. White blood cell count
D. Sodium level
Rationale: Clozapine can cause agranulocytosis, requiring WBC monitoring.
Clients taking SSRIs should be monitored early in therapy for:
A. Hypoglycemia
B. Cardiac arrhythmias
C. Fever, hyperreflexia, agitation, and hallucinations
D. Jaundice
Rationale: These symptoms indicate serotonin syndrome, most likely within 2–72 hours.
Which adverse effect of Elavil reflects its anticholinergic properties?
A. Bradycardia
B. Photophobia