Berne and Levy Physiology 7th Edition Koeppen
Berne and Levy Physiology 8th Edition KoeppenTest Bank Koep
pen: Berne and Levy Physiology, 8th Edition
Chapter 01: Principles of Cell Function
Test Bank
Multiple Choice
1. The subcellular structure that degrades proteins is called the:
A. Tight junction
B. Mitochondria
C. Lysosome
D. Plasma membrane
E. Ribosome
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The follo
wing data are obtained:
N
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevent
s the cell from making adenosine triphosphate (ATP), the uptake of amino acid into the c
ell is markedly reduced. According to this information, which of the followingmechanism
s is probably responsible for the transport of the amino acid into the cell?
A. Passive diffusion through the lipid bilayer
B. Uniporter
C. Transport ATPase
D. Na+ symporter
E. Na+ antiporter
ANS: D
3. A membrane permeable by only Na+ separates two compartments containi
ng Na2SO4,shown as follows:
,Berne and Levy Physiology 7th Edition Koeppen
Electrodes are placed in both compartments, and a voltage is applied (that of compartment
A is held at 0 mV). What voltage applied to compartment B would resultin no net move
ment of Na+ across the membrane separating the compartments?
A. –60 mV
B. –30 mV
C. 0 mV
D. +30 mV
E.
+60 m
V ANS: E
4. The resting membrane potentN ial oRf a Ic e l lGis –
B85.m U S
CV. The intracellular and extracellular
nw concentrations of several ions are indicate
d in the following table, as is the calculated
Nernst equilibrium potential (Ei) for each of these ions:
Ion Concentration Concentration Ei
Inside Cell Outside Cell
Na+ 12 mEq/L 145 mEq/L 66 mV
K+ 150 mEq/L 4 mEq/L –96 mV
Cl– 30 mEq/L 105 mEq/L –33 mV
Ca++ 0.0001 mmol/dL 1 mmol/dL 122 mV
The membrane has channels for Na+, K+, Cl–
, and Ca++. The conductance of the membrane is the greatest for which ion?
A. Na+
B. K+
C. Cl–
D. Ca++
ANS:
B
5. A cell contains the following membrane transporters:
Na+ channelK+ channe
l Na+,K+-ATPase
The resting membrane voltage of the cell is –80 mV, and the intracellular and
extracellular ion concentrations are as follows:
Ion Intracellular Extracellular
Concentration Concentration
Na+ 10 mEq/L 145 mEq/L
K+ 120 mEq/L 4 mEq/L
,Berne and Levy Physiology 7th Edition Koeppen
The cell is treated with a drug to inhibit the Na+,K+-
ATPase. What would be the effect ofthis drug on the following parameters?
Intracellular [Na+] Intracellular [K+] Cell Volume Membrane Voltage
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane
by a glycosylphosphatidylinositol (GPI) anchor?
ANS: E
7. A cell has channels for Na+, K+, and Cl–
in its plasma membrane. The resting membrane potential is –
60 mV (cell interior negative). The intracellular and extracellular concentrations
for these ions, as well as the calculated Nernst potentials, are listed as follows:
Ion Intracellular Extracellular Ei
Concentration Concentration
Na+ 14 mEq/L 140 mEq/L 60 mV
K+ 150 mEq/L 5 mEq/L –89 mV
Cl– 10 mEq/L 100 mEq/L –60 mV
A drug is applied to the cell that increases the permeability of the cell by Cl–
(i.e., it opens Cl–
channels). What effect will this drug have on the net movement of Cl–
acrossthe plasma membrane?
A. Net Cl– movement out of the cell will be increased.
B. Net Cl– movement into the cell will be increased.
C. There will be no change in the net movement of Cl–.
ANS: C
, Berne and Levy Physiology 7th Edition Koeppen
8. Reducing the extracellular [K+] would be expected to have which of the follo
wing effects on the resting membrane potential and on the excitability of ve
ntricular myocytes?
Membrane Potential Excitability
A. Unchanged Unchanged
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
D. Depolarized Decreased
E. Depolarized Increased
ANS: B
9. A cell is bathed in an isotonic NaCl solution that contains 5 mmol/L of glucose.
The intracellular concentration of glucose is 10 mmol/L. What is the most likely me
chanism for the transport of glucose across the plasma membrane into this cell?
A. Glucose uniporter
B. Na+-glucose symporter
C. Na+-glucose antiporter
D. Diffusion of glucose through the lipid bilayer of the membra
ne ANS: B
10. A blood sample is taken from an individual whose blood osmolality is 295 mOsm
per kilogram of water. Red blood cells from this sample are then placed in the
following solutions:
1-5
Solution Osmolality (mOsm/kg H2O) Reflection
Coefficien
t ( of
nw
Solute
1. NaCl 300 1
2. Fructose 300 0.5
3. Urea 300 0
4. CaCl2 100 1
5. KCl 150 1
The red blood cells in which of these solutions will swell to the greatest degree?
A. 1
B. 2
C. 3
D. 4
E. 5 ANS
:C
Berne and Levy Physiology 8th Edition KoeppenTest Bank Koep
pen: Berne and Levy Physiology, 8th Edition
Chapter 01: Principles of Cell Function
Test Bank
Multiple Choice
1. The subcellular structure that degrades proteins is called the:
A. Tight junction
B. Mitochondria
C. Lysosome
D. Plasma membrane
E. Ribosome
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The follo
wing data are obtained:
N
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevent
s the cell from making adenosine triphosphate (ATP), the uptake of amino acid into the c
ell is markedly reduced. According to this information, which of the followingmechanism
s is probably responsible for the transport of the amino acid into the cell?
A. Passive diffusion through the lipid bilayer
B. Uniporter
C. Transport ATPase
D. Na+ symporter
E. Na+ antiporter
ANS: D
3. A membrane permeable by only Na+ separates two compartments containi
ng Na2SO4,shown as follows:
,Berne and Levy Physiology 7th Edition Koeppen
Electrodes are placed in both compartments, and a voltage is applied (that of compartment
A is held at 0 mV). What voltage applied to compartment B would resultin no net move
ment of Na+ across the membrane separating the compartments?
A. –60 mV
B. –30 mV
C. 0 mV
D. +30 mV
E.
+60 m
V ANS: E
4. The resting membrane potentN ial oRf a Ic e l lGis –
B85.m U S
CV. The intracellular and extracellular
nw concentrations of several ions are indicate
d in the following table, as is the calculated
Nernst equilibrium potential (Ei) for each of these ions:
Ion Concentration Concentration Ei
Inside Cell Outside Cell
Na+ 12 mEq/L 145 mEq/L 66 mV
K+ 150 mEq/L 4 mEq/L –96 mV
Cl– 30 mEq/L 105 mEq/L –33 mV
Ca++ 0.0001 mmol/dL 1 mmol/dL 122 mV
The membrane has channels for Na+, K+, Cl–
, and Ca++. The conductance of the membrane is the greatest for which ion?
A. Na+
B. K+
C. Cl–
D. Ca++
ANS:
B
5. A cell contains the following membrane transporters:
Na+ channelK+ channe
l Na+,K+-ATPase
The resting membrane voltage of the cell is –80 mV, and the intracellular and
extracellular ion concentrations are as follows:
Ion Intracellular Extracellular
Concentration Concentration
Na+ 10 mEq/L 145 mEq/L
K+ 120 mEq/L 4 mEq/L
,Berne and Levy Physiology 7th Edition Koeppen
The cell is treated with a drug to inhibit the Na+,K+-
ATPase. What would be the effect ofthis drug on the following parameters?
Intracellular [Na+] Intracellular [K+] Cell Volume Membrane Voltage
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane
by a glycosylphosphatidylinositol (GPI) anchor?
ANS: E
7. A cell has channels for Na+, K+, and Cl–
in its plasma membrane. The resting membrane potential is –
60 mV (cell interior negative). The intracellular and extracellular concentrations
for these ions, as well as the calculated Nernst potentials, are listed as follows:
Ion Intracellular Extracellular Ei
Concentration Concentration
Na+ 14 mEq/L 140 mEq/L 60 mV
K+ 150 mEq/L 5 mEq/L –89 mV
Cl– 10 mEq/L 100 mEq/L –60 mV
A drug is applied to the cell that increases the permeability of the cell by Cl–
(i.e., it opens Cl–
channels). What effect will this drug have on the net movement of Cl–
acrossthe plasma membrane?
A. Net Cl– movement out of the cell will be increased.
B. Net Cl– movement into the cell will be increased.
C. There will be no change in the net movement of Cl–.
ANS: C
, Berne and Levy Physiology 7th Edition Koeppen
8. Reducing the extracellular [K+] would be expected to have which of the follo
wing effects on the resting membrane potential and on the excitability of ve
ntricular myocytes?
Membrane Potential Excitability
A. Unchanged Unchanged
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
D. Depolarized Decreased
E. Depolarized Increased
ANS: B
9. A cell is bathed in an isotonic NaCl solution that contains 5 mmol/L of glucose.
The intracellular concentration of glucose is 10 mmol/L. What is the most likely me
chanism for the transport of glucose across the plasma membrane into this cell?
A. Glucose uniporter
B. Na+-glucose symporter
C. Na+-glucose antiporter
D. Diffusion of glucose through the lipid bilayer of the membra
ne ANS: B
10. A blood sample is taken from an individual whose blood osmolality is 295 mOsm
per kilogram of water. Red blood cells from this sample are then placed in the
following solutions:
1-5
Solution Osmolality (mOsm/kg H2O) Reflection
Coefficien
t ( of
nw
Solute
1. NaCl 300 1
2. Fructose 300 0.5
3. Urea 300 0
4. CaCl2 100 1
5. KCl 150 1
The red blood cells in which of these solutions will swell to the greatest degree?
A. 1
B. 2
C. 3
D. 4
E. 5 ANS
:C
