MSRA Haematology - platelet disorder
h7 h7 h7 h7
1. whath7ish7thrombocytosis:h7plateleth7>450
2. whath7areh7theh7causesh7ofh7thrombocytosis:h7infection,h7inflammation,h7posth7surgery,h7IDA
3. primaryh7causesh7ofh7thrombocythaemia:h7essentialh7thrombocythaemia
4. whath7mutationh7ish7seenh7inh7ET:h7JAK2h7orh7CALR
5. whath7ish7ET,h7pVh7andh7myelofibrosis:h7myeloproliferativeh7disorder
6. clinicalh7featuresh7ofh7ET:h7plateletsh7>600,h7burningh7extremities,h7thormbosis,h7bleedingh7dueh7
toh7dysfunctionalh7platelets,h7mildh7splenomeglay
7. lowh7riskh7ETh7mgxh7(<60,h7noh7hxh7ofh7thrombosis):h7aspirinh7monotherpay
8. intermediateh7riskh7ETh7mgxh7(>60h7withh7hxh7ofh7thrombosis):h7hydroxycarbamide
9. historyh7ofh7venoush7thrombosis:h7anticoag
10. hxh7ofh7arterialh7thrombosis:h7aspirinh7BD
11. 3h7importanth7causesh7ofh7thrombocytopenia:h7ITP,h7TTPh7andh7HIT
12. broadh7causesh7ofh7lowh7platelets:h7immune,h7consumptive,h7drugh7induced,h7sequestration,h7infe
ctionh7related,h7boneh7marrowh7supression
13. pathoh7physh7ofh7ITP:h7igGh7autoantibodiesh7targeth7G2b.3ah7receptorh7causingh7preamtureh7destr
uctionh7ofh7plateletsh7inh7theh7spleen
h7 h7 h7 h7
1. whath7ish7thrombocytosis:h7plateleth7>450
2. whath7areh7theh7causesh7ofh7thrombocytosis:h7infection,h7inflammation,h7posth7surgery,h7IDA
3. primaryh7causesh7ofh7thrombocythaemia:h7essentialh7thrombocythaemia
4. whath7mutationh7ish7seenh7inh7ET:h7JAK2h7orh7CALR
5. whath7ish7ET,h7pVh7andh7myelofibrosis:h7myeloproliferativeh7disorder
6. clinicalh7featuresh7ofh7ET:h7plateletsh7>600,h7burningh7extremities,h7thormbosis,h7bleedingh7dueh7
toh7dysfunctionalh7platelets,h7mildh7splenomeglay
7. lowh7riskh7ETh7mgxh7(<60,h7noh7hxh7ofh7thrombosis):h7aspirinh7monotherpay
8. intermediateh7riskh7ETh7mgxh7(>60h7withh7hxh7ofh7thrombosis):h7hydroxycarbamide
9. historyh7ofh7venoush7thrombosis:h7anticoag
10. hxh7ofh7arterialh7thrombosis:h7aspirinh7BD
11. 3h7importanth7causesh7ofh7thrombocytopenia:h7ITP,h7TTPh7andh7HIT
12. broadh7causesh7ofh7lowh7platelets:h7immune,h7consumptive,h7drugh7induced,h7sequestration,h7infe
ctionh7related,h7boneh7marrowh7supression
13. pathoh7physh7ofh7ITP:h7igGh7autoantibodiesh7targeth7G2b.3ah7receptorh7causingh7preamtureh7destr
uctionh7ofh7plateletsh7inh7theh7spleen