Pharmacotherapeutics for Advanced Practice: A Practical Approach
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by Virginia Poole Arcangelo, Andrew M. Peterson
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Fifth Edition
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,Chapter 1 Issues for the Practitioner in Drug Therapy
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MULTIPLEMCHOICE
1. NurseMpractitionerMprescriptiveMauthorityMisMregulatedMby:
A. TheMNationalMCouncilMofMStateMBoardsMofMNursing
B. TheMU.S.MDrugMEnforcementMAdministration
C. TheMStateMBoardMofMNursingMforMeachMstate
D. TheMStateMBoardMofMPharmacy
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2. PhysicianMAssistantM(PA)MprescriptiveMauthorityMisMregulatedMby:
A. TheMNationalMCouncilMofMStateMBoardsMofMNursing
B. TheMU.S.MDrugMEnforcementMAdministration
C. TheMStateMBoardMofMNursing
D. TheMStateMBoardMofMMedicalMExaminers
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3. ClinicalMjudgmentMinMprescribingMincludes:
A. FactoringMinMtheMcostMtoMtheMpatientMofMtheMmedicationMprescribed
B. AlwaysMprescribingMtheMnewestMmedicationMavailableMforMtheMdiseaseMprocess
C. HandingMoutMdrugMsamplesMtoMpoorMpatients
D. PrescribingMallMgenericMmedicationsMtoMcutMcosts
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4. CriteriaMforMchoosingManMeffectiveMdrugMforMaMdisorderMinclude:
A. AskingMtheMpatientMwhatMdrugMtheyMthinkMwouldMworkMbestMforMthem
B. ConsultingMnationallyMrecognizedMguidelinesMforMdiseaseMmanagement
C. PrescribingMmedicationsMthatMareMavailableMasMsamplesMbeforeMwritingMaMprescription
D. FollowingMU.S.MDrugMEnforcementMAdministrationM(DEA)MguidelinesMf
orMprescribing
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5. NurseMpractitionerMpracticeMmayMthriveMunderMhealth-careMreformMdueMto:
A. TheMdemonstratedMabilityMofMnurseMpractitionersMtoMcontrolMcostsMandMimproveMpati
entMoutcomes
B. TheMfactMthatMnurseMpractitionersMwillMbeMableMtoMpracticeMindependently
C. TheMfactMthatMnurseMpractitionersMwillMhaveMfullMreimbursementMunderMhealth-
careMreform
D. TheMabilityMtoMshiftMaccountabilityMforMMedicaidMtoMtheMstateMlevel
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Chapter 2.Pharmacokinetic Basis of Therapeutics and Pharmacodynamic
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MULTIPLEMCHOICE
1. AMpatient'sMnutritionalMintakeMandMlabMworkMreflectsMhypoalbuminemia.MThisMisMcritica
lMtoMprescribingMbecause:
A. DistributionMofMdrugsMtoMtargetMtissueMmayMbeMaffected
B. TheMsolubilityMofMtheMdrugMwillMnotMmatchMtheMsiteMofMabsorption
C. ThereMwillMbeMlessMfreeMdrugMavailableMtoMgenerateManMeffect
D. DrugsMboundMtoMalbuminMareMreadilyMexcretedMbyMtheMkidney
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2. DrugsMthatMhaveMaMsignificantMfirst-passMeffect:
A. MustMbeMgivenMbyMtheMenteralM(oral)MrouteMonly
B. BypassMtheMhepaticMcirculation
C. AreMrapidlyMmetabolizedMbyMtheMliverMandMmayMhaveMlittleMifManyMdesiredMaction
D. AreMconvertedMbyMtheMliverMtoMmoreMactiveMandMfat-solubleMforms
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3. TheMrouteMofMexcretionMofMaMvolatileMdrugMwillMlikelyMbe:
A. TheMkidneys
B. TheMlungs
C. TheMbileMandMfeces
D. TheMskin
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4. MedroxyprogesteroneM(DepoMProvera)MisMprescribedMIMMtoMcreateMaMstorageMreservoirMof
MtheMdrug.MStorageMreservoirs:
A. AssureMthatMtheMdrugMwillMreachMitsMintendedMtargetMtissue
B. AreMtheMreasonMforMgivingMloadingMdoses
C. IncreaseMtheMlengthMofMtimeMaMdrugMisMavailableMandMactive
D. AreMmostMcommonMinMcollagenMtissues
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5. TheMNPMchoosesMtoMgiveMcephalexinMeveryM8MhoursMbasedMonMknowledgeMofMtheMdrug's:
A. PropensityMtoMgoMtoMtheMtargetMreceptor
B. BiologicalMhalf-life
C. Pharmacodynamics
D. SafetyMandMsideMeffects
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6. AzithromycinMdosingMrequiresMtheMfirstMday'sMdoseMbeMtwiceMthoseMofMtheMotherM4MdaysMo
fMtheMprescription.MThisMisMconsideredMaMloadingMdose.MAMloadingMdose:
A. RapidlyMachievesMdrugMlevelsMinMtheMtherapeuticMrange
B. RequiresMfourMtoMfiveMhalf-livesMtoMattain
C. IsMinfluencedMbyMrenalMfunction
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D. IsMdirectlyMrelatedMtoMtheMdrugMcirculatingMtoMtheMtargetMtissues
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7. TheMpointMinMtimeMonMtheMdrugMconcentrationMcurveMthatMindicatesMtheMfirstMsignMofMaMtherap
euticMeffectMisMthe:
A. MinimumMadverseMeffectMlevel
B. PeakMofMaction
C. OnsetMofMaction
D. TherapeuticMrange
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8. PhenytoinMrequiresMaMtroughMlevelMbeMdrawn.MPeakMandMtroughMlevelsMareMdone:
A. WhenMtheMdrugMhasMaMwideMtherapeuticMrange
B. WhenMtheMdrugMwillMbeMadministeredMforMaMshortMtimeMonly
C. WhenMthereMisMaMhighMcorrelationMbetweenMtheMdoseMandMsaturationMofMreceptorMsites
D. ToMdetermineMifMaMdrugMisMinMtheMtherapeuticMrange
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9. AMlaboratoryMresultMindicatesMtheMpeakMlevelMforMaMdrugMisMaboveMtheMminimumMt
oxicMconcentration.MThisMmeansMthatMthe:
A. ConcentrationMwillMproduceMtherapeuticMeffects
B. ConcentrationMwillMproduceManMadverseMresponse
C. TimeMbetweenMdosesMmustMbeMshortened
D. DurationMofMactionMofMtheMdrugMisMtooMlong
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10. DrugsMthatMareMreceptorMagonistsMmayMdemonstrateMwhatMproperty?
A. IrreversibleMbindingMtoMtheMdrugMreceptorMsite
B. Up-regulationMwithMchronicMuse
C. DesensitizationMorMdown-regulationMwithMcontinuousMuse
D. InverseMrelationshipMbetweenMdrugMconcentrationMandMdrugMaction
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11. DrugsMthatMareMreceptorMantagonists,MsuchMasMbetaMblockers,MmayMcause:
A. Down-regulationMofMtheMdrugMreceptor
B. AnMexaggeratedMresponseMifMabruptlyMdiscontinued
C. PartialMblockadeMofMtheMeffectsMofMagonistMdrugs
D. AnMexaggeratedMresponseMtoMcompetitiveMdrugMagonists
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12. FactorsMthatMaffectMgastricMdrugMabsorptionMinclude:
A. LiverMenzymeMactivity
B. Protein-bindingMpropertiesMofMtheMdrugMmolecule
C. LipidMsolubilityMofMtheMdrug
D. AbilityMtoMchewMandMswallow
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