1. phasee t Ie t trials:e t focusetonettestingettoxicityetandetmetabolismetinethealthyetvolunteers
2. phasee t IIe t trials:e t aimettoetassessetettectivenessetandettoxicityetinettheettargetetpopulation
3. phaseetIIIettrials:etinvolvesetwidespreadettestingetonetaetdiverseetpopulation
4. phaseetIVettrials:etexamineetwhetherettheetdrugethasetotheretpotentialetuses
5. levelsetofetorganizationetofetbody:etatomset--->etmoleculeset--->etcellset--->ettissueset--->etorganset--->bodyetsystemset-
-->ettotaletbody
- theseetorganizationaletlevelsetensureetthatettheetbodyetcanetperformetessentialetfunctionsetlikeetobtainingetfoodetandetoxygen,eteliminati
ngetwaste,etandetrespondingettoetenvironmentaletchanges
6. fouretprimaryetcellettypes:etepithelialetc
onnective
nerveetmuscle
7. epithelial:etcoversetbodyetsurfacesetandetlinesetorgans
8. connective:e t includesetblood,etbone,etandetfat;etsupportsetandetbindsetotherettissues
9. nerve:e t excitatoryetcellsetthatetgenerateetandettransmitetsignals
10. muscle:etalsoetexcitatory,etresponsibleetforetcontractionetandetmovement
11. setpoint:e t theettargetetvalueettheetsystemettriesettoetmaintainet(e.g.,etbodyettemperatureetatet37°c)
12. variable:ettheetchangingetfactoretbeingetregulated
13. sensoret(receptor):etdetectsetchangesetinettheetvariable
14. effector:etmakesetadjustmentsettoetbringettheetvariableetbackettoettheetsetpoint
15. controletcenteret(integrator):etreceivesetinputetfrometsensorsetandetdirectsetettectors
, 16. feedbacketcanetbe:etpositive,etnegativeetoretfeedforward
17. positivee t feedback:e t amplifiesetchangeset(e.g.,etchildbirth,etactionetpotentials)
18. negativee t feedback:e t opposesetchangesetandetmaintainsetstabilityet(e.g.,etmostethomeostasisetprocesses)
2. phasee t IIe t trials:e t aimettoetassessetettectivenessetandettoxicityetinettheettargetetpopulation
3. phaseetIIIettrials:etinvolvesetwidespreadettestingetonetaetdiverseetpopulation
4. phaseetIVettrials:etexamineetwhetherettheetdrugethasetotheretpotentialetuses
5. levelsetofetorganizationetofetbody:etatomset--->etmoleculeset--->etcellset--->ettissueset--->etorganset--->bodyetsystemset-
-->ettotaletbody
- theseetorganizationaletlevelsetensureetthatettheetbodyetcanetperformetessentialetfunctionsetlikeetobtainingetfoodetandetoxygen,eteliminati
ngetwaste,etandetrespondingettoetenvironmentaletchanges
6. fouretprimaryetcellettypes:etepithelialetc
onnective
nerveetmuscle
7. epithelial:etcoversetbodyetsurfacesetandetlinesetorgans
8. connective:e t includesetblood,etbone,etandetfat;etsupportsetandetbindsetotherettissues
9. nerve:e t excitatoryetcellsetthatetgenerateetandettransmitetsignals
10. muscle:etalsoetexcitatory,etresponsibleetforetcontractionetandetmovement
11. setpoint:e t theettargetetvalueettheetsystemettriesettoetmaintainet(e.g.,etbodyettemperatureetatet37°c)
12. variable:ettheetchangingetfactoretbeingetregulated
13. sensoret(receptor):etdetectsetchangesetinettheetvariable
14. effector:etmakesetadjustmentsettoetbringettheetvariableetbackettoettheetsetpoint
15. controletcenteret(integrator):etreceivesetinputetfrometsensorsetandetdirectsetettectors
, 16. feedbacketcanetbe:etpositive,etnegativeetoretfeedforward
17. positivee t feedback:e t amplifiesetchangeset(e.g.,etchildbirth,etactionetpotentials)
18. negativee t feedback:e t opposesetchangesetandetmaintainsetstabilityet(e.g.,etmostethomeostasisetprocesses)
