ANCC PRACTICE QUESTIONS DOMAIN 3 TRUSTED
EXAM PREP | ACCURATE & UPDATED 2025–2026
In distinguishing HIV-related depression from HIV dementia, which of the following findings
would be indicative of HIV dementia?
a. Apathy and inertia
b. Incoordination
c. Decreased motivation
d. Diminished attention and concentration - correct answer -B
Clozapine is associated with severe neutropenia (absolute neutrophil count (ANC) less than
500/?L). The requirements to prescribe, dispense, and receive Clozapine are incorporated into a
single, shared program called the Clozapine Risk Evaluation and Mitigation Strategy (REMS).
Who implement the Clozapine Risk Evaluation and Mitigation Strategy (REMS)?
a. A Federal Drug Administration (FDA)
b. Centers for Disease Control and Prevention (CDC)
c. Health and Human Services
d. The manufactures of Clozapine (Clozaril) - correct answer -D
You have a 16-year-old patient who suffers from Binge Eating Disorder. She is 5 foot 10 inches
tall (70 inches) and has a BMI of 30. You consult the National Guideline Clearing House for the
best information on treating the patient. Part of your treatment plan includes:
a. Implementing non-diet health at every size therapy in addition to psychotherapy to help with
weight stabilization and binge eating
b. Treatment with Duloxetine (Cymbalta) long-term at low doses and a reduced calorie diet. It is
associated with significant weight loss.
c. Urine specific gravity, orthostatic vital signs, and oral temperatures taken on a regular basis.
d. Use of Sibutramine (Meridia) 10 mg po QAM and a reduced calorie diet. It is associated with
significant weight loss. - correct answer -A
,When evaluating a 5-year-old child with language deficits, which of the following is a key
indicator in differentiating autistic disorder from a mixed receptive-expressive language
disorder.
a. Imaginative play is predominant form of expression
b. Language abnormalities such as echolalia are common
c. Family history of speech delay or language problems
d. Level of intelligence ranges from mild to severe impairment - correct answer -B
A client says that because he wished his sister was dead, and your client's sister subsequently
was killed in a motor vehicle accident, the death was caused by the client's wishes. The client
also revealed that he can read other's minds. This client is most likely suffering from which
personality disorder?
a. Schizotypal Personality Disorder
b. Schizoid Personality Disorder
c. Paranoid Personality Disorder
d. Delusional Personality Disorder - correct answer -A
Which of the following atypical antipsychotic medications has U.S. FDA approval for treatment
of bipolar depression when combined with fluoxetine (Prozac)?
a. Quetiapine (Seroquel)
b. Olanzapine (Zyprexa)
c. Aripiprazole (Abilify)
d. Risperidone (Risperdal) - correct answer -B
The PMHNP treating a patient for schizophrenia on ziprasidone orders and EKG. Which QTc
interval result places the patient at greatest risk for torsade's de points?
a. 160-260 milliseconds
, b. 300-500 milliseconds
c. 500-700 milliseconds
d. 100-200 milliseconds - correct answer -C
A pervasive pattern of grandiosity, lack of empathy, and need for admiration suggests the
diagnosis of which of the following personality disorders?
a. Paranoid
b. Borderline
c. Schizotypal
d. Narcissistic - correct answer -D
When counseling a 52-year-old perimenopausal woman with nocturnal hot flashes, anxiety,
depressed mood, low energy, little motivation, diminished sex drive, and work-related stress,
what lifestyle changes and complementary therapies would be evidence-based
recommendations to consider when this patient does not want to be on hormone replacement
or antidepressant medication?
a. Yoga, isoflavinoids, and black cohosh
b. Walking, St. John's Wort, and black cohosh
c. Tai chi, dietary soy, and flaxseed
d. Current evidence does not support the efficacy of complementary therapies for
perimenopausal or depressive symptoms - correct answer -C
In managing the maintenance phase for Bipolar I Disorder, which of the following statements is
not supported by current evidence in the literature?
a. Lamotrigine, but not lithium, is superior to placebo in preventing a depressive episode.
b. Extended-release formulation of carbamazepine is equivalent to lithium in preventing a
manic, hypomanic, or mixed episode.
c. Both lamotrigine and lithium are superior to placebo in delaying onset of mood-related
episodes.
EXAM PREP | ACCURATE & UPDATED 2025–2026
In distinguishing HIV-related depression from HIV dementia, which of the following findings
would be indicative of HIV dementia?
a. Apathy and inertia
b. Incoordination
c. Decreased motivation
d. Diminished attention and concentration - correct answer -B
Clozapine is associated with severe neutropenia (absolute neutrophil count (ANC) less than
500/?L). The requirements to prescribe, dispense, and receive Clozapine are incorporated into a
single, shared program called the Clozapine Risk Evaluation and Mitigation Strategy (REMS).
Who implement the Clozapine Risk Evaluation and Mitigation Strategy (REMS)?
a. A Federal Drug Administration (FDA)
b. Centers for Disease Control and Prevention (CDC)
c. Health and Human Services
d. The manufactures of Clozapine (Clozaril) - correct answer -D
You have a 16-year-old patient who suffers from Binge Eating Disorder. She is 5 foot 10 inches
tall (70 inches) and has a BMI of 30. You consult the National Guideline Clearing House for the
best information on treating the patient. Part of your treatment plan includes:
a. Implementing non-diet health at every size therapy in addition to psychotherapy to help with
weight stabilization and binge eating
b. Treatment with Duloxetine (Cymbalta) long-term at low doses and a reduced calorie diet. It is
associated with significant weight loss.
c. Urine specific gravity, orthostatic vital signs, and oral temperatures taken on a regular basis.
d. Use of Sibutramine (Meridia) 10 mg po QAM and a reduced calorie diet. It is associated with
significant weight loss. - correct answer -A
,When evaluating a 5-year-old child with language deficits, which of the following is a key
indicator in differentiating autistic disorder from a mixed receptive-expressive language
disorder.
a. Imaginative play is predominant form of expression
b. Language abnormalities such as echolalia are common
c. Family history of speech delay or language problems
d. Level of intelligence ranges from mild to severe impairment - correct answer -B
A client says that because he wished his sister was dead, and your client's sister subsequently
was killed in a motor vehicle accident, the death was caused by the client's wishes. The client
also revealed that he can read other's minds. This client is most likely suffering from which
personality disorder?
a. Schizotypal Personality Disorder
b. Schizoid Personality Disorder
c. Paranoid Personality Disorder
d. Delusional Personality Disorder - correct answer -A
Which of the following atypical antipsychotic medications has U.S. FDA approval for treatment
of bipolar depression when combined with fluoxetine (Prozac)?
a. Quetiapine (Seroquel)
b. Olanzapine (Zyprexa)
c. Aripiprazole (Abilify)
d. Risperidone (Risperdal) - correct answer -B
The PMHNP treating a patient for schizophrenia on ziprasidone orders and EKG. Which QTc
interval result places the patient at greatest risk for torsade's de points?
a. 160-260 milliseconds
, b. 300-500 milliseconds
c. 500-700 milliseconds
d. 100-200 milliseconds - correct answer -C
A pervasive pattern of grandiosity, lack of empathy, and need for admiration suggests the
diagnosis of which of the following personality disorders?
a. Paranoid
b. Borderline
c. Schizotypal
d. Narcissistic - correct answer -D
When counseling a 52-year-old perimenopausal woman with nocturnal hot flashes, anxiety,
depressed mood, low energy, little motivation, diminished sex drive, and work-related stress,
what lifestyle changes and complementary therapies would be evidence-based
recommendations to consider when this patient does not want to be on hormone replacement
or antidepressant medication?
a. Yoga, isoflavinoids, and black cohosh
b. Walking, St. John's Wort, and black cohosh
c. Tai chi, dietary soy, and flaxseed
d. Current evidence does not support the efficacy of complementary therapies for
perimenopausal or depressive symptoms - correct answer -C
In managing the maintenance phase for Bipolar I Disorder, which of the following statements is
not supported by current evidence in the literature?
a. Lamotrigine, but not lithium, is superior to placebo in preventing a depressive episode.
b. Extended-release formulation of carbamazepine is equivalent to lithium in preventing a
manic, hypomanic, or mixed episode.
c. Both lamotrigine and lithium are superior to placebo in delaying onset of mood-related
episodes.
