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PCEUT (Department of Pharmaceutics ) Bundle Set
PCEUT (Department of Pharmaceutics ) Bundle Set
[Mostrar más]PCEUT (Department of Pharmaceutics ) Bundle Set
[Mostrar más]oral bioavialability (F) - Answer the fraction of an orally administered dose of drug that reaches systemic circulation unchanged 
 
F = (bioavailable dose)/(oral dose) 
 
describes the extent to which a drug is absorbed from GI tract into systemic circulation 
 
factors decreasing oral bioavaila...
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Añadir al carritooral bioavialability (F) - Answer the fraction of an orally administered dose of drug that reaches systemic circulation unchanged 
 
F = (bioavailable dose)/(oral dose) 
 
describes the extent to which a drug is absorbed from GI tract into systemic circulation 
 
factors decreasing oral bioavaila...
In theory, in a dispersed system, if cohesive force is greater than adhesive force, phase separation will occur. - Answer True 
 
The higher the HLB value of a surfactant, the more hydrophobic the surfactant is. - Answer False 
 
In general, hydrophilic surfactants tend to be used to formulate O...
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Añadir al carritoIn theory, in a dispersed system, if cohesive force is greater than adhesive force, phase separation will occur. - Answer True 
 
The higher the HLB value of a surfactant, the more hydrophobic the surfactant is. - Answer False 
 
In general, hydrophilic surfactants tend to be used to formulate O...
The salting-out effect is attributed to a competition between solute molecules for the solvent - Answer TRUE 
 
Packaging of a drug is usually not considered to be part of compounding of a dosage form - Answer FALSE 
 
Solutions are homogenous liquid mixtures in which the solute is dispersed thr...
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Añadir al carritoThe salting-out effect is attributed to a competition between solute molecules for the solvent - Answer TRUE 
 
Packaging of a drug is usually not considered to be part of compounding of a dosage form - Answer FALSE 
 
Solutions are homogenous liquid mixtures in which the solute is dispersed thr...
Dispersed systems - Answer When one component (drug) is distributed more or less uniformly throughout the second component (medium), the mixture is called a dispersion system in which surfactants are often added. 
 
particle diameter in molecular dispersions (i.e. solutions) - Answer < 1.0 nm...
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Añadir al carritoDispersed systems - Answer When one component (drug) is distributed more or less uniformly throughout the second component (medium), the mixture is called a dispersion system in which surfactants are often added. 
 
particle diameter in molecular dispersions (i.e. solutions) - Answer < 1.0 nm...
Stability - Answer Extent to which a drug product retains, within specified limits, throughout its period of storage and use, the same properties and characteristics that it possessed at the time of its manufacture 
 
Forced degradation studies - Answer Studying effects of very extreme condition...
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Añadir al carritoStability - Answer Extent to which a drug product retains, within specified limits, throughout its period of storage and use, the same properties and characteristics that it possessed at the time of its manufacture 
 
Forced degradation studies - Answer Studying effects of very extreme condition...
tablets - Answer solid dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding 
 
Compression - Answer large scale 
 
Molding - Answer small scale 
 
Compressed tablets - Answer prepared by single compression with no special coa...
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Añadir al carritotablets - Answer solid dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding 
 
Compression - Answer large scale 
 
Molding - Answer small scale 
 
Compressed tablets - Answer prepared by single compression with no special coa...
melt, dissolve, soften - Answer Suppositories, inserts, and sticks are solid dosage forms and/or intended for insertion into body orifices where they ___________, __________, and/or __________. 
 
False - Answer True or False: There may be only one API dispersed in a suitable base and molded or ...
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Añadir al carritomelt, dissolve, soften - Answer Suppositories, inserts, and sticks are solid dosage forms and/or intended for insertion into body orifices where they ___________, __________, and/or __________. 
 
False - Answer True or False: There may be only one API dispersed in a suitable base and molded or ...
modified-release dosage forms - Answer alter the timing, rate and/or the location of release of the drug substances to achieve a desired therapeutic objective or better patient compliance 
 
timing 
rate 
location - Answer what do modified-release dosage forms alter about drug release 
 
therape...
Vista previa 2 fuera de 10 páginas
Añadir al carritomodified-release dosage forms - Answer alter the timing, rate and/or the location of release of the drug substances to achieve a desired therapeutic objective or better patient compliance 
 
timing 
rate 
location - Answer what do modified-release dosage forms alter about drug release 
 
therape...
Suspensions definition - Answer Liquid preparations that consist of solid particles Dispersed through out a liquid phase in which particles are not soluble. 
 
Product Types - Answer Oral suspensions 
Topical Suspensions 
Sterile suspensions for injection 
 
Oral suspensions - Answer Aluminum ...
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Añadir al carritoSuspensions definition - Answer Liquid preparations that consist of solid particles Dispersed through out a liquid phase in which particles are not soluble. 
 
Product Types - Answer Oral suspensions 
Topical Suspensions 
Sterile suspensions for injection 
 
Oral suspensions - Answer Aluminum ...
T/F: Drugs that form MI complexes with CYP enzymes (e.g., macrolide antibiotics) can cause the irreversible loss of active enzyme. - Answer T 
 
T/F: When considering an interaction between the CYP3A inhibitor ritonavir and voriconazole, the magnitude of change in voriconazole AUC can be strongly ...
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Añadir al carritoT/F: Drugs that form MI complexes with CYP enzymes (e.g., macrolide antibiotics) can cause the irreversible loss of active enzyme. - Answer T 
 
T/F: When considering an interaction between the CYP3A inhibitor ritonavir and voriconazole, the magnitude of change in voriconazole AUC can be strongly ...
Percutaneous Absorption: Topical Drug Administration for Local or Systemic Effect - Answer Percutaneous absorption is the process by which drug passes into and/or through the skin after application to the surface of the skin. Equivalent terms include: 
• topical drug administration 
• dermal d...
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Añadir al carritoPercutaneous Absorption: Topical Drug Administration for Local or Systemic Effect - Answer Percutaneous absorption is the process by which drug passes into and/or through the skin after application to the surface of the skin. Equivalent terms include: 
• topical drug administration 
• dermal d...
Ointments are prepared by two general methods: ___ and ___ - Answer incorporation 
 
fusion 
 
Levigation - Answer triturating a powder drug with a solvent in which it is insoluble to reduce its particle size 
 
___, a general method of ointment preparation, involves mixing the ingredients of t...
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Añadir al carritoOintments are prepared by two general methods: ___ and ___ - Answer incorporation 
 
fusion 
 
Levigation - Answer triturating a powder drug with a solvent in which it is insoluble to reduce its particle size 
 
___, a general method of ointment preparation, involves mixing the ingredients of t...
Radiopharmacy - Answer radiopharmaceuticals prepared for human use and therefore strict QC and safe handling of radiopharmaceuticals must be maintained 
 
Radiopharmacy is the _______ recognized pharmacy subspecialty - Answer first 
 
Nuclear Medicine - Answer use of radioactive compounds for ...
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Añadir al carritoRadiopharmacy - Answer radiopharmaceuticals prepared for human use and therefore strict QC and safe handling of radiopharmaceuticals must be maintained 
 
Radiopharmacy is the _______ recognized pharmacy subspecialty - Answer first 
 
Nuclear Medicine - Answer use of radioactive compounds for ...
Antibodies and RNA-based therapeutics belong to a new class of therapeutics called "biologics". - Answer True 
 
Dosage form of a medication usually has little to do with clinical effectiveness of the drug. - Answer False 
 
The "Pharmacokinetics" of a drug refers to the time course of drug ...
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Añadir al carritoAntibodies and RNA-based therapeutics belong to a new class of therapeutics called "biologics". - Answer True 
 
Dosage form of a medication usually has little to do with clinical effectiveness of the drug. - Answer False 
 
The "Pharmacokinetics" of a drug refers to the time course of drug ...
Cisplatin MOA - Answer •Nephrotoxicity•Ototoxicity•Motor & sensory peripheral neuropathy•N/V 
 
Cisplatin toxicity - Answer •Nephrotoxicity•Ototoxicity•Motor & sensory peripheral neuropathy•N/V 
 
Cisplatin treatment for SE - Answer •Infusion of normal saline to keep Cl conc ...
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Añadir al carritoCisplatin MOA - Answer •Nephrotoxicity•Ototoxicity•Motor & sensory peripheral neuropathy•N/V 
 
Cisplatin toxicity - Answer •Nephrotoxicity•Ototoxicity•Motor & sensory peripheral neuropathy•N/V 
 
Cisplatin treatment for SE - Answer •Infusion of normal saline to keep Cl conc ...
Whats the definition of a drug interaction? - Answer When the effects of one drug are modified by the prior &/or concurrent administration of another pharmacologically active substance. 
 
Define object Drug - Answer an Object drug is a drug *being affected* by the interaction. The DDI can affec...
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Añadir al carritoWhats the definition of a drug interaction? - Answer When the effects of one drug are modified by the prior &/or concurrent administration of another pharmacologically active substance. 
 
Define object Drug - Answer an Object drug is a drug *being affected* by the interaction. The DDI can affec...
T/F: The first FDA approved gene therapy clinical trial was for the metabolic disorder X-SCID - Answer F 
first gene therapy to receive approval in the Western world: Glybera (apolipogene tiparvovc) - gene therapy for LPLD. Approved by the European Commission. 
 
T/F: Currently, there is no FDA ap...
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Añadir al carritoT/F: The first FDA approved gene therapy clinical trial was for the metabolic disorder X-SCID - Answer F 
first gene therapy to receive approval in the Western world: Glybera (apolipogene tiparvovc) - gene therapy for LPLD. Approved by the European Commission. 
 
T/F: Currently, there is no FDA ap...
obstacles to delivery to anterior eye - Answer -spillage during instillation 
-lacrimal drainage 
-tear dilution 
-systemic absorption 
-corneal barriers to drug diffusion 
-enzymatic breakdown of drugs 
-binding of drug by uveal pigment 
 
problems with use of conventional eye drops - Answer -t...
Vista previa 2 fuera de 6 páginas
Añadir al carritoobstacles to delivery to anterior eye - Answer -spillage during instillation 
-lacrimal drainage 
-tear dilution 
-systemic absorption 
-corneal barriers to drug diffusion 
-enzymatic breakdown of drugs 
-binding of drug by uveal pigment 
 
problems with use of conventional eye drops - Answer -t...
What is a cytokine - Answer hormone-like proteins secreted by 
many cell types (leukocytes; fibroblasts). Cytokines regulate the intensity and duration of the immune response, involved in cell-to-cell comminication 
 
What is an interleukin - Answer a cytokine produced by leukocytes 
 
What is ...
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Añadir al carritoWhat is a cytokine - Answer hormone-like proteins secreted by 
many cell types (leukocytes; fibroblasts). Cytokines regulate the intensity and duration of the immune response, involved in cell-to-cell comminication 
 
What is an interleukin - Answer a cytokine produced by leukocytes 
 
What is ...
modified-release dosage forms - Answer alter the timing, rate and/or the location of release of the drug substances to achieve a desired therapeutic objective or better patient compliance 
 
timing 
rate 
location - Answer what do modified-release dosage forms alter about drug release 
 
therape...
Vista previa 2 fuera de 10 páginas
Añadir al carritomodified-release dosage forms - Answer alter the timing, rate and/or the location of release of the drug substances to achieve a desired therapeutic objective or better patient compliance 
 
timing 
rate 
location - Answer what do modified-release dosage forms alter about drug release 
 
therape...
what is the angle of repose? - Answer a measurement of the flow properties of a powder. made by measuring the height and radius the pile of powder when you let it fall through a funnel. 
 
A high angle of repose means the powder flows- - Answer poorly 
 
a low angle of repose means the powder flow...
Vista previa 2 fuera de 14 páginas
Añadir al carritowhat is the angle of repose? - Answer a measurement of the flow properties of a powder. made by measuring the height and radius the pile of powder when you let it fall through a funnel. 
 
A high angle of repose means the powder flows- - Answer poorly 
 
a low angle of repose means the powder flow...
T/F: Regarding the membrane permeability coefficient (i.e. permeability or P) of a drug molecule: For a given membrane, permeability is determined by the physiochemical properties of the drug such as molecular size, lipophilicity and ionization state. - Answer T 
 
T/F: Regarding the membrane perm...
Vista previa 2 fuera de 6 páginas
Añadir al carritoT/F: Regarding the membrane permeability coefficient (i.e. permeability or P) of a drug molecule: For a given membrane, permeability is determined by the physiochemical properties of the drug such as molecular size, lipophilicity and ionization state. - Answer T 
 
T/F: Regarding the membrane perm...
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