ANS 407 EXAM 1 QUESTIONS AND CORRECT ANSWE
er er er er er er er
RS
Doseerresponseerrelationshiper-ercorrecteranswer✔ ✔
Relationshiperbetweenerleveleroferexposureertoeraerxenobioticerandertheermagnitudeerofertheerbiologi
calerresponseerthateriserbeingermeasured
LD50er-ercorrecteranswer✔ ✔ Doseerrangeerthaterwillerkiller50%eroferanimalserexposed
Systemicereffectser-ercorrecteranswer✔ ✔
effectingeroneerorermoreerorganserafterertheerchemicalerhaserbeenerabsorbederanderdistributedertoeroth
ererpartserofertheerbody
Xenobioticer-ercorrecteranswer✔ ✔
chemicalerthaterisernoteraerparterofertheernormalermetabolismerofertheeranimal
Toxiner-ercorrecteranswer✔ ✔ aerchemicalerfromeraerplanteroreranimal
Toxicanter-ercorrecteranswer✔ ✔ non-biologicalerchemical
Sigmoidercurveer-ercorrecteranswer✔ ✔ relativelyerstraighterlineergraph
Majorerrouteeroferxenobioticerexposure?er-ercorrecteranswer✔ ✔ Gastrointestinalertract
Mostereffectiveerrouteseroferexposure?erRanker3ermostertoerleaster-ercorrecteranswer✔ ✔
Intravenouser>erinhalationer>intraperitoneal
Subacuteeriserhowermanyerdays?er-ercorrecteranswer✔ ✔ Lesserthaner30erdays
, Subchroniceriserhowerlong?er-ercorrecteranswer✔ ✔ 30-90erdays
Chroniceriserhowerlong?er-ercorrecteranswer✔ ✔ Moreerthaner90erdays
Aerquantityeroferxenobioticerthatercausesersevereerreactionerwillerdoerwhateriferadministerederinersevera
lerdoses?er-ercorrecteranswer✔ ✔ Mayernoterhaveeranereffecterifergivenerinerseveralerdoses
Effectseroccurerfromerprolongederexposureeronlyerif...er-ercorrecteranswer✔ ✔
Xenobioticeraccumulates
Xenobioticercauseserirreversibleereffects
Noterenoughertimeerforersystemertoerrecovererbetweenerdoses
Ruleeroferthumberforer1erlbersprayederpereracreageerresultserinerhowermanyermg/chemicalerexposureerp
ererkgeroferbodyweight?er-ercorrecteranswer✔ ✔
1erlb/chemicalersprayederpereracreerresultseriner7ermg/chemicalerpererkgerbodyweight
Absorptioner-ercorrecteranswer✔ ✔
Processerbyerwhicherxenobioticserpasserthrougherbodyermembraneseranderenterercirculation
Polarerregionsercomposederoferionizederaminoeraciderresidueserareerlocatederwhereerinertheermembrane
?er-ercorrecteranswer✔ ✔ Hydrophilicerexterior
Nonpolarerregionsercomposederoferneutraleraminoeracidserareerlocatederwhere?er-ercorrecteranswer✔
✔ Lipophilicermiddleerofertheermembrane
Whaterisertheermosterimportantermechanismerofertransporterforerxenobiotics?er-ercorrecteranswer✔
✔ Passiveerdiffusion
Whaterareertheer3errequirementserforerpassiveerdiffusionertoeroccur?er-ercorrecteranswer✔ ✔
1.erMusterbeerconcentrationergradienteracrossermembrane
er er er er er er er
RS
Doseerresponseerrelationshiper-ercorrecteranswer✔ ✔
Relationshiperbetweenerleveleroferexposureertoeraerxenobioticerandertheermagnitudeerofertheerbiologi
calerresponseerthateriserbeingermeasured
LD50er-ercorrecteranswer✔ ✔ Doseerrangeerthaterwillerkiller50%eroferanimalserexposed
Systemicereffectser-ercorrecteranswer✔ ✔
effectingeroneerorermoreerorganserafterertheerchemicalerhaserbeenerabsorbederanderdistributedertoeroth
ererpartserofertheerbody
Xenobioticer-ercorrecteranswer✔ ✔
chemicalerthaterisernoteraerparterofertheernormalermetabolismerofertheeranimal
Toxiner-ercorrecteranswer✔ ✔ aerchemicalerfromeraerplanteroreranimal
Toxicanter-ercorrecteranswer✔ ✔ non-biologicalerchemical
Sigmoidercurveer-ercorrecteranswer✔ ✔ relativelyerstraighterlineergraph
Majorerrouteeroferxenobioticerexposure?er-ercorrecteranswer✔ ✔ Gastrointestinalertract
Mostereffectiveerrouteseroferexposure?erRanker3ermostertoerleaster-ercorrecteranswer✔ ✔
Intravenouser>erinhalationer>intraperitoneal
Subacuteeriserhowermanyerdays?er-ercorrecteranswer✔ ✔ Lesserthaner30erdays
, Subchroniceriserhowerlong?er-ercorrecteranswer✔ ✔ 30-90erdays
Chroniceriserhowerlong?er-ercorrecteranswer✔ ✔ Moreerthaner90erdays
Aerquantityeroferxenobioticerthatercausesersevereerreactionerwillerdoerwhateriferadministerederinersevera
lerdoses?er-ercorrecteranswer✔ ✔ Mayernoterhaveeranereffecterifergivenerinerseveralerdoses
Effectseroccurerfromerprolongederexposureeronlyerif...er-ercorrecteranswer✔ ✔
Xenobioticeraccumulates
Xenobioticercauseserirreversibleereffects
Noterenoughertimeerforersystemertoerrecovererbetweenerdoses
Ruleeroferthumberforer1erlbersprayederpereracreageerresultserinerhowermanyermg/chemicalerexposureerp
ererkgeroferbodyweight?er-ercorrecteranswer✔ ✔
1erlb/chemicalersprayederpereracreerresultseriner7ermg/chemicalerpererkgerbodyweight
Absorptioner-ercorrecteranswer✔ ✔
Processerbyerwhicherxenobioticserpasserthrougherbodyermembraneseranderenterercirculation
Polarerregionsercomposederoferionizederaminoeraciderresidueserareerlocatederwhereerinertheermembrane
?er-ercorrecteranswer✔ ✔ Hydrophilicerexterior
Nonpolarerregionsercomposederoferneutraleraminoeracidserareerlocatederwhere?er-ercorrecteranswer✔
✔ Lipophilicermiddleerofertheermembrane
Whaterisertheermosterimportantermechanismerofertransporterforerxenobiotics?er-ercorrecteranswer✔
✔ Passiveerdiffusion
Whaterareertheer3errequirementserforerpassiveerdiffusionertoeroccur?er-ercorrecteranswer✔ ✔
1.erMusterbeerconcentrationergradienteracrossermembrane
