ANS 407 Exam 1 Questions With Complete Solutions
3 common plasma proteins besides albumin? Correct Answers
Transferrin, ceruloplasmin, alpha/beta lipoprotein
A larger partition coefficient means what? Correct Answers
Easier to pass through membranes, more lipophilic
A quantity of xenobiotic that causes severe reaction will do what
if administered in several doses? Correct Answers May not
have an effect if given in several doses
Absorption Correct Answers Process by which xenobiotics pass
through body membranes and enter circulation
Alicyclic hydroxylation Correct Answers Addition of a
hydroxyl group to a saturated ring (no double bonds) made up of
the SAME atom
Aliphatic hydroxylation Correct Answers Addition of an -OH
group to an aliphatic group (open-chain compound, or simple
cyclic compounds)
Aromatic hydroxylation Correct Answers Addition of an -OH
to BENZENE
Barrier between the air in the alveoli and blood stream may be
as thin as __ membranes thick Correct Answers 2
, Castration of males or administration of androgens to females
will do what? Correct Answers Eliminate xenobiotic
metabolism differences between the sexes
Chronic is how long? Correct Answers More than 90 days
Deamination Correct Answers Removal of an amine group
(NH2)
Desulfuration Correct Answers Replacement of a sulfur atom
with an oxygen atom
Dose response relationship Correct Answers Relationship
between level of exposure to a xenobiotic and the magnitude of
the biological response that is being measured
Effects occur from prolonged exposure only if... Correct
Answers Xenobiotic accumulates
Xenobiotic causes irreversible effects
Not enough time for system to recover between doses
Extent and rate of absorption of aerosols in the lungs depends on
what? Correct Answers Particle size
Heterocyclic hydroxylation Correct Answers Addition of a
hydroxyl group to a ring made up of MORE THAN one kind of
atom
How big is the lungs surface area? Correct Answers 50-100 m2
3 common plasma proteins besides albumin? Correct Answers
Transferrin, ceruloplasmin, alpha/beta lipoprotein
A larger partition coefficient means what? Correct Answers
Easier to pass through membranes, more lipophilic
A quantity of xenobiotic that causes severe reaction will do what
if administered in several doses? Correct Answers May not
have an effect if given in several doses
Absorption Correct Answers Process by which xenobiotics pass
through body membranes and enter circulation
Alicyclic hydroxylation Correct Answers Addition of a
hydroxyl group to a saturated ring (no double bonds) made up of
the SAME atom
Aliphatic hydroxylation Correct Answers Addition of an -OH
group to an aliphatic group (open-chain compound, or simple
cyclic compounds)
Aromatic hydroxylation Correct Answers Addition of an -OH
to BENZENE
Barrier between the air in the alveoli and blood stream may be
as thin as __ membranes thick Correct Answers 2
, Castration of males or administration of androgens to females
will do what? Correct Answers Eliminate xenobiotic
metabolism differences between the sexes
Chronic is how long? Correct Answers More than 90 days
Deamination Correct Answers Removal of an amine group
(NH2)
Desulfuration Correct Answers Replacement of a sulfur atom
with an oxygen atom
Dose response relationship Correct Answers Relationship
between level of exposure to a xenobiotic and the magnitude of
the biological response that is being measured
Effects occur from prolonged exposure only if... Correct
Answers Xenobiotic accumulates
Xenobiotic causes irreversible effects
Not enough time for system to recover between doses
Extent and rate of absorption of aerosols in the lungs depends on
what? Correct Answers Particle size
Heterocyclic hydroxylation Correct Answers Addition of a
hydroxyl group to a ring made up of MORE THAN one kind of
atom
How big is the lungs surface area? Correct Answers 50-100 m2
