Secondary Lymphoid Organs and Immune
Response Organization Questions and
Answers
What is the primary function of secondary lymphoid organs? - ✅✅To initiate and organize the
immune response to antigens.
Where do T lymphocytes mature? - ✅✅In the thymus.
Where do B cells, monocytes, dendritic cells, and granulocytes mature? - ✅✅In the bone marrow.
What are the most organized secondary lymphoid organs? - ✅✅Lymph nodes and the spleen.
What anatomical feature do lymph nodes and the spleen share? - ✅✅They are compartmentalized
from the rest of the body by a fibrous capsule.
What are barrier tissues? - ✅✅Less organized secondary lymphoid tissues associated with the linings
of multiple organ systems that protect against external pathogens.
What key regions are found in all secondary lymphoid structures? - ✅✅Anatomically distinct regions
of T-cell and B-cell activity.
What are lymphoid follicles responsible for? - ✅✅The development and selection of B cells that
produce high-affinity antibodies.
How do immune cells traffic through tissues? - ✅✅Using the blood and lymphatic systems.
What is the role of endothelial cells in the blood vessels? - ✅✅They respond to inflammatory signals
and help recruit circulating white blood cells to infected tissue.
, How do red and white blood cells travel through the blood? - ✅✅Red blood cells flow away from the
heart via arteries and return via veins; white blood cells also transit through this system.
What is the primary function of the lymphatic system? - ✅✅To provide a route for activated immune
cells and antigens to travel from sites of infection to secondary lymphoid organs.
What fluid is contained in lymphatic vessels? - ✅✅Lymph, which is derived from the fluid component
of blood (plasma).
What happens if interstitial fluid is not returned to circulation? - ✅✅Tissues would swell, resulting in
edema, specifically called lymphedema.
What is lymphedema? - ✅✅Swelling due to the accumulation of interstitial fluid when it is not
returned to the circulation.
What are the walls of primary lymphatic vessels like compared to blood vessels? - ✅✅Thinner and
more porous, consisting of a single layer of loosely apposed endothelial cells.
What is the significance of chemokine gradients in immune response? - ✅✅They guide white blood
cells to the site of infection.
What is the exception regarding the vascular supply of the spleen? - ✅✅The spleen is primarily
served by blood vessels rather than lymphatic vessels.
How much interstitial fluid can an adult generate in a 24-hour period? - ✅✅2.9 liters or more.
What could happen if lymphatic vessels are damaged? - ✅✅It could lead to lymphedema due to
impaired fluid drainage.
What types of cells can access the lymphatic system? - ✅✅Only white blood cells.
Response Organization Questions and
Answers
What is the primary function of secondary lymphoid organs? - ✅✅To initiate and organize the
immune response to antigens.
Where do T lymphocytes mature? - ✅✅In the thymus.
Where do B cells, monocytes, dendritic cells, and granulocytes mature? - ✅✅In the bone marrow.
What are the most organized secondary lymphoid organs? - ✅✅Lymph nodes and the spleen.
What anatomical feature do lymph nodes and the spleen share? - ✅✅They are compartmentalized
from the rest of the body by a fibrous capsule.
What are barrier tissues? - ✅✅Less organized secondary lymphoid tissues associated with the linings
of multiple organ systems that protect against external pathogens.
What key regions are found in all secondary lymphoid structures? - ✅✅Anatomically distinct regions
of T-cell and B-cell activity.
What are lymphoid follicles responsible for? - ✅✅The development and selection of B cells that
produce high-affinity antibodies.
How do immune cells traffic through tissues? - ✅✅Using the blood and lymphatic systems.
What is the role of endothelial cells in the blood vessels? - ✅✅They respond to inflammatory signals
and help recruit circulating white blood cells to infected tissue.
, How do red and white blood cells travel through the blood? - ✅✅Red blood cells flow away from the
heart via arteries and return via veins; white blood cells also transit through this system.
What is the primary function of the lymphatic system? - ✅✅To provide a route for activated immune
cells and antigens to travel from sites of infection to secondary lymphoid organs.
What fluid is contained in lymphatic vessels? - ✅✅Lymph, which is derived from the fluid component
of blood (plasma).
What happens if interstitial fluid is not returned to circulation? - ✅✅Tissues would swell, resulting in
edema, specifically called lymphedema.
What is lymphedema? - ✅✅Swelling due to the accumulation of interstitial fluid when it is not
returned to the circulation.
What are the walls of primary lymphatic vessels like compared to blood vessels? - ✅✅Thinner and
more porous, consisting of a single layer of loosely apposed endothelial cells.
What is the significance of chemokine gradients in immune response? - ✅✅They guide white blood
cells to the site of infection.
What is the exception regarding the vascular supply of the spleen? - ✅✅The spleen is primarily
served by blood vessels rather than lymphatic vessels.
How much interstitial fluid can an adult generate in a 24-hour period? - ✅✅2.9 liters or more.
What could happen if lymphatic vessels are damaged? - ✅✅It could lead to lymphedema due to
impaired fluid drainage.
What types of cells can access the lymphatic system? - ✅✅Only white blood cells.
