https://www.stuvia.com/
Https://www.stuvia.com/
Test Bank
Modern Blood Banking & Transfusion Practices
By Denise M. Harmening
7th edition
,https://www.stuvia.com/
Table of contents
part i fundamental concepts
1 red blood cell and platelet preservation: historical perspectives and current trends
2 basic genetics
3 fundamentals of immunology
4 concepts in molecular biology
Part ii blood groups and serological testing
5 the antiglobulin test
6 the abo blood group system
7 the rh blood group system
8 blood group terminology & common blood groups: the lewis system, p, i, mns, kell, duffy, kidd, lutheran
9 uncommon blood groups
10 detection and identification of antibodies
11 pre-transfusion testing
12 blood bank testing technologies and automation
Part iii transfusion practices
13 donor selection
14 transfusion-transmitted diseases
15 component preparation
16 transfusion therapy
17 adverse effects of blood transfusion
18 apheresis
19 cellular therapy in the transplant setting
20 hemolytic disease of the fetus and newborn
21 autoimmune hemolytic anemias
22 tissue banking
Part iv leukocyte antigens and relationship testing
23 the hla system
24 relationship testing
Part v quality management and compliance
25 quality management in the blood bank
26 patient blood management
27 transfusion safety and federal regulatory requirements
28 laboratory information systems in the blood bank
29 medicolegal and ethical aspects of providing blood collection and transfusion services
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chapter 1 rbcs and platelet preservation: historical perspectives and current trends
Multiple choice
Identify the choice that best completes the statement or answers the question.
1. Which metabolic pathway is responsible for generating 90% of the atp for the rbc?
a. Pentose phosphate shunt c. Glycolysis
b. Luebering-rapoport shunt d. Methemoglobin reductase
2. a unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s iv failed. The
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a
ccurate?
a. The unit of blood should be discarded immediately.
b. The unit of blood can be returned to inventory.
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
d. the unit of blood must be transfused with 24 hours.
3. what is the average diameter of a platelet?
a. 5 to 10 µm c. 1 to 2 µm
b. 2 to 4 µm d. 4 to 6 µm
4. in the normal hemoglobin-
Oxygen dissociation curve, what percentage of oxygen is releasedkto the tissueskwhen po2 averages 4
0 mm hg?
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
a. Storage temperature c. Platelet count
b. Initial ph d. All of thekabove
6. which of the following red blood cellkmorphologies maykbekpresent on the peripheral blood smear as a re
sult of loss of rbc membrane?
a. Spherocytes c. Burr cells
b. Target cells d. Schistocytes
7. What does the term autologous transfusionkrefer to?
a. A parent donating blood for his orkher child
b. An individualkdonating bloodkfor a friend
c. An individualkdonating blood forka relative
d. Ankindividual donating bloodkfor his or her own transfusion
8. what is thekprimary functionkof hemoglobin?
a. Iron metabolism c. Oxygen transport
b. Porphyrin synthesis d. Signal transduction
9. all of the followingkareas of red blood cell biology are crucial for normal erythrocyte survival except:
a. Cellular metabolism. C. Site of the abo antigen attachment.
b. Rbc membrane. D. Hemoglobin structure.
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10. What is the correct biochemical composition of the rbc membrane?
a. 52% protein, 40% lipid, 8% carbohydrate
b. 40% protein, 8% lipid, 52% carbohydrate
c. 8% protein, 52% lipid, 40% carbohydrate
d. 8% lipid, 40% carbohydrate, 52% protein
11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
Except:
a. Decreased ph. C. Increased atp level.
b. Loss of red blood cell function. D. Decreased glucose consumption.
12. Which red blood cell preservative has a storage time of 35 days?
a. Acd c. As-1
b. cpda-1 d. Cpd
13. The rbc membrane is relatively permeable to all of the following except:
a. Chloride. C. Bicarbonate.
b. Sodium. D. Water.
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromk
the bone marrow?
a. 30% c. 10%
b. 50% d. 25%
15. What is the major biochemical consideration in plateletkstorage?
a. Glucose metabolism c. Production of carbon dioxide
b. Oxygen supply d.k regulation ofkph
16. What would the hemoglobin-
Oxygen dissociation curve depict in akpatient exhibitingkclinical signs of alkalosis?
a. Normal c. Shift tokthe right
b. Shift to the left d.k none of the above
17. Name the main lipid components of a red blood cell membrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin a
18. The abo bloodkgroups were discovered in 1901 by whom?
a. Charleskdrew c. Loutit and mollison
b. Karlklandsteiner d. Edward lindeman
19. A standing order of plateletskwas shipped to your facility by your supplier. It was inadvertently left in th
e corner of the departmentkuntil discovered 36 hours later. What would the appropriate action be for the
blood banker?
a. If the temperature in the box was 22 +/-
2°c and the platelet swirl seemed ok, it would be ok to accept the unit into inventor y.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
discarded because the ph has probably dropped too low and platelet activation has be
en compromised.
c. If the temperature was 1°c to 6°c and the platelet swirl seemed ok, it would be ok to
Https://www.stuvia.com/
Test Bank
Modern Blood Banking & Transfusion Practices
By Denise M. Harmening
7th edition
,https://www.stuvia.com/
Table of contents
part i fundamental concepts
1 red blood cell and platelet preservation: historical perspectives and current trends
2 basic genetics
3 fundamentals of immunology
4 concepts in molecular biology
Part ii blood groups and serological testing
5 the antiglobulin test
6 the abo blood group system
7 the rh blood group system
8 blood group terminology & common blood groups: the lewis system, p, i, mns, kell, duffy, kidd, lutheran
9 uncommon blood groups
10 detection and identification of antibodies
11 pre-transfusion testing
12 blood bank testing technologies and automation
Part iii transfusion practices
13 donor selection
14 transfusion-transmitted diseases
15 component preparation
16 transfusion therapy
17 adverse effects of blood transfusion
18 apheresis
19 cellular therapy in the transplant setting
20 hemolytic disease of the fetus and newborn
21 autoimmune hemolytic anemias
22 tissue banking
Part iv leukocyte antigens and relationship testing
23 the hla system
24 relationship testing
Part v quality management and compliance
25 quality management in the blood bank
26 patient blood management
27 transfusion safety and federal regulatory requirements
28 laboratory information systems in the blood bank
29 medicolegal and ethical aspects of providing blood collection and transfusion services
,https://www.stuvia.com/
chapter 1 rbcs and platelet preservation: historical perspectives and current trends
Multiple choice
Identify the choice that best completes the statement or answers the question.
1. Which metabolic pathway is responsible for generating 90% of the atp for the rbc?
a. Pentose phosphate shunt c. Glycolysis
b. Luebering-rapoport shunt d. Methemoglobin reductase
2. a unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s iv failed. The
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a
ccurate?
a. The unit of blood should be discarded immediately.
b. The unit of blood can be returned to inventory.
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
d. the unit of blood must be transfused with 24 hours.
3. what is the average diameter of a platelet?
a. 5 to 10 µm c. 1 to 2 µm
b. 2 to 4 µm d. 4 to 6 µm
4. in the normal hemoglobin-
Oxygen dissociation curve, what percentage of oxygen is releasedkto the tissueskwhen po2 averages 4
0 mm hg?
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
a. Storage temperature c. Platelet count
b. Initial ph d. All of thekabove
6. which of the following red blood cellkmorphologies maykbekpresent on the peripheral blood smear as a re
sult of loss of rbc membrane?
a. Spherocytes c. Burr cells
b. Target cells d. Schistocytes
7. What does the term autologous transfusionkrefer to?
a. A parent donating blood for his orkher child
b. An individualkdonating bloodkfor a friend
c. An individualkdonating blood forka relative
d. Ankindividual donating bloodkfor his or her own transfusion
8. what is thekprimary functionkof hemoglobin?
a. Iron metabolism c. Oxygen transport
b. Porphyrin synthesis d. Signal transduction
9. all of the followingkareas of red blood cell biology are crucial for normal erythrocyte survival except:
a. Cellular metabolism. C. Site of the abo antigen attachment.
b. Rbc membrane. D. Hemoglobin structure.
,https://www.stuvia.com/
10. What is the correct biochemical composition of the rbc membrane?
a. 52% protein, 40% lipid, 8% carbohydrate
b. 40% protein, 8% lipid, 52% carbohydrate
c. 8% protein, 52% lipid, 40% carbohydrate
d. 8% lipid, 40% carbohydrate, 52% protein
11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
Except:
a. Decreased ph. C. Increased atp level.
b. Loss of red blood cell function. D. Decreased glucose consumption.
12. Which red blood cell preservative has a storage time of 35 days?
a. Acd c. As-1
b. cpda-1 d. Cpd
13. The rbc membrane is relatively permeable to all of the following except:
a. Chloride. C. Bicarbonate.
b. Sodium. D. Water.
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromk
the bone marrow?
a. 30% c. 10%
b. 50% d. 25%
15. What is the major biochemical consideration in plateletkstorage?
a. Glucose metabolism c. Production of carbon dioxide
b. Oxygen supply d.k regulation ofkph
16. What would the hemoglobin-
Oxygen dissociation curve depict in akpatient exhibitingkclinical signs of alkalosis?
a. Normal c. Shift tokthe right
b. Shift to the left d.k none of the above
17. Name the main lipid components of a red blood cell membrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin a
18. The abo bloodkgroups were discovered in 1901 by whom?
a. Charleskdrew c. Loutit and mollison
b. Karlklandsteiner d. Edward lindeman
19. A standing order of plateletskwas shipped to your facility by your supplier. It was inadvertently left in th
e corner of the departmentkuntil discovered 36 hours later. What would the appropriate action be for the
blood banker?
a. If the temperature in the box was 22 +/-
2°c and the platelet swirl seemed ok, it would be ok to accept the unit into inventor y.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
discarded because the ph has probably dropped too low and platelet activation has be
en compromised.
c. If the temperature was 1°c to 6°c and the platelet swirl seemed ok, it would be ok to
