Umbilical Cord Blood
● Fetus makes the placenta
● having no nuclei = no mathcing
Glaucoma and Macular Degeneration
● Vision becomes worse with age
● Vision impairment is more prominent in women than men
● Western countries have less vision impairment
● Cataract = most common cause of blindness
○ physician have been solving this by simply removing the lens for many
years
● Age related macular degeneration is not treatable (degeneration in center of
retina)
● Many DS people have macular degeneration
● Only solution is to stimulate retinal neurogenesis and then these neurons
send axons to the brain
● Diabetes affects the blood vessels and contribute to retinal damage
● Why Exosomes
○ contain many non coding rna
○ packages of miRNA piRNA siRNA (don’t code for proteins, they inhibit
other rna)
● Meiboman secrete oily tears (put oil in tears, prevent evaporation of tears)
● Parkinson’s disease people don’t get glaucoma
● Role of PTEN
● SOC3
● Lipin 1
● Regrow retinal ganglion cells you have to also grow optic nerve
● Umbilical cord blood have genes inhibiting PTEN, SOC3, Lipin 1
Lithium Therapeutics
● Many children with Down Syndrome also have Autism
● Autism => some parts of the brain works better than average person
● Started treating Down Syndrome with Lithium (neural stem cells)
○ strongly stimulate neural precursor cells to proliferate
○ suppressed astrogliogenesis (production of astrocytes)
● feeding animals with Lithium (pregnant mothers)
● lithium exchanges in the kidneys
● ½ of all human DS babies are miscarriages
● insect blue liquid to pregnant women
○ all the DS babies (placenta) turned blue
○ albumin
● Fetus makes the placenta
● having no nuclei = no mathcing
Glaucoma and Macular Degeneration
● Vision becomes worse with age
● Vision impairment is more prominent in women than men
● Western countries have less vision impairment
● Cataract = most common cause of blindness
○ physician have been solving this by simply removing the lens for many
years
● Age related macular degeneration is not treatable (degeneration in center of
retina)
● Many DS people have macular degeneration
● Only solution is to stimulate retinal neurogenesis and then these neurons
send axons to the brain
● Diabetes affects the blood vessels and contribute to retinal damage
● Why Exosomes
○ contain many non coding rna
○ packages of miRNA piRNA siRNA (don’t code for proteins, they inhibit
other rna)
● Meiboman secrete oily tears (put oil in tears, prevent evaporation of tears)
● Parkinson’s disease people don’t get glaucoma
● Role of PTEN
● SOC3
● Lipin 1
● Regrow retinal ganglion cells you have to also grow optic nerve
● Umbilical cord blood have genes inhibiting PTEN, SOC3, Lipin 1
Lithium Therapeutics
● Many children with Down Syndrome also have Autism
● Autism => some parts of the brain works better than average person
● Started treating Down Syndrome with Lithium (neural stem cells)
○ strongly stimulate neural precursor cells to proliferate
○ suppressed astrogliogenesis (production of astrocytes)
● feeding animals with Lithium (pregnant mothers)
● lithium exchanges in the kidneys
● ½ of all human DS babies are miscarriages
● insect blue liquid to pregnant women
○ all the DS babies (placenta) turned blue
○ albumin
