BMTCN Chapter 7 Survivorship Issues question n answers graded A+ 2023/2024

BMTCN Chapter 7 Survivorship IssuesWhat is a patient who received a T-cell-depleted transplant at risk for developing within the first year following transplant? A. Acute myeloid leukemia B. Breast cancer C. Basal cell carcinoma D. Post-transplant lymphoproliferative disorders - correct answer D. Post-transplant lymphoproliferative disorders What is the most common secondary malignancy in pediatric patients who receive radiation as part of the transplant conditioning regimen? A. Esophageal cancer B. Thyroid cancer C. Nonsquamous cell carcinoma D. Brain stem glioma - correct answer C. Nonsquamous cell carcinoma Which of the following is true of human papillomavirus (HPV) infections? A. Exposure does not increase patients' risk of developing secondary cancers. B. Because patients are not at a significant risk following transplant, vaccination is not necessary. C. HPV can significantly increase patients' risk of developing post-transplant lymphoproliferative disorder. D. Patients between the ages of 9 and 26 should be revaccinated post-transplant with the HPV vaccine. - correct answer D. Patients between the ages of 9 and 26 should be revaccinated post-transplant with the HPV vaccine. With which of the following are post-transplant lymphoproliferative disorders strongly associated? A. Donor B cells infected with the Epstein-Barr virus (EBV) B. Donor T cells infected with EBV C. They are not associated with viral infections. D. Sibling myeloablative transplants - correct answer A. Donor B cells infected with the Epstein-Barr virus (EBV) Which of the following is NOT a risk for developing secondary solid tumors? A. Genetic predisposition B. Chronic graft-versus-host disease (GVHD) C. An increased incidence within the first 12 months following transplant D. Younger age at transplant - correct answer C. An increased incidence within the first 12 months following transplant Acute myeloid leukemia without features of myelodysplastic syndrome is most often associated with patients who received which of the following? A. Fractionated total body irradiation B. Antithymocyte globulin (ATG) C. A topoisomerase II inhibitor D. An alkylating agent - correct answer C. A topoisomerase II inhibitor (doxorubicin, etoposide, and mitoxantron) The risk of ovarian failure, regardless of pubertal status, is associated with the use of which chemotherapy? A. Fludarabine and cyclophosphamide B. Busulfan and cyclophosphamide C. Etoposide and carmustine